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Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies

Vassy, Jason L.; Shrader, Peter; Jonsson, Anna LU ; Fox, Caroline S.; Lyssenko, Valeriya LU ; Isomaa, Bo; Groop, Leif LU ; Meigs, James B. and Franks, Paul LU (2011) In Diabetes Research and Clinical Practice 93(2). p.76-79
Abstract
Objective: Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown. Methods: We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study). Results: Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend) = 0.03). The trend was similar among Framingham Offspring but was not statistically significant (p = 0.07). The meta-analyzed p value for... (More)
Objective: Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown. Methods: We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study). Results: Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend) = 0.03). The trend was similar among Framingham Offspring but was not statistically significant (p = 0.07). The meta-analyzed p value for trend from the two studies was 0.005. Conclusions: The very modest associations reported above suggest that the increased risk of diabetes in offspring of parents with diabetes is largely the result of shared environmental/lifestyle factors and/or hitherto unknown genetic factors. (C) 2011 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Type 2 diabetes mellitus, Genetic risk score, Family history
in
Diabetes Research and Clinical Practice
volume
93
issue
2
pages
76 - 79
publisher
Elsevier
external identifiers
  • wos:000293825400007
  • scopus:80051556037
ISSN
1872-8227
DOI
10.1016/j.diabres.2011.04.013
language
English
LU publication?
yes
id
feda56ef-315b-4bc5-af89-874fdd5b27b8 (old id 2162097)
date added to LUP
2011-10-03 08:37:24
date last changed
2017-05-28 03:25:02
@article{feda56ef-315b-4bc5-af89-874fdd5b27b8,
  abstract     = {Objective: Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown. Methods: We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study). Results: Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend) = 0.03). The trend was similar among Framingham Offspring but was not statistically significant (p = 0.07). The meta-analyzed p value for trend from the two studies was 0.005. Conclusions: The very modest associations reported above suggest that the increased risk of diabetes in offspring of parents with diabetes is largely the result of shared environmental/lifestyle factors and/or hitherto unknown genetic factors. (C) 2011 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Vassy, Jason L. and Shrader, Peter and Jonsson, Anna and Fox, Caroline S. and Lyssenko, Valeriya and Isomaa, Bo and Groop, Leif and Meigs, James B. and Franks, Paul},
  issn         = {1872-8227},
  keyword      = {Type 2 diabetes mellitus,Genetic risk score,Family history},
  language     = {eng},
  number       = {2},
  pages        = {76--79},
  publisher    = {Elsevier},
  series       = {Diabetes Research and Clinical Practice},
  title        = {Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies},
  url          = {http://dx.doi.org/10.1016/j.diabres.2011.04.013},
  volume       = {93},
  year         = {2011},
}