Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies
(2011) In Diabetes Research and Clinical Practice 93(2). p.76-79- Abstract
- Objective: Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown. Methods: We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study). Results: Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend) = 0.03). The trend was similar among Framingham Offspring but was not statistically significant (p = 0.07). The meta-analyzed p value for... (More)
- Objective: Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown. Methods: We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study). Results: Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend) = 0.03). The trend was similar among Framingham Offspring but was not statistically significant (p = 0.07). The meta-analyzed p value for trend from the two studies was 0.005. Conclusions: The very modest associations reported above suggest that the increased risk of diabetes in offspring of parents with diabetes is largely the result of shared environmental/lifestyle factors and/or hitherto unknown genetic factors. (C) 2011 Elsevier Ireland Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2162097
- author
- Vassy, Jason L. ; Shrader, Peter ; Jonsson, Anna LU ; Fox, Caroline S. ; Lyssenko, Valeriya LU ; Isomaa, Bo ; Groop, Leif LU ; Meigs, James B. and Franks, Paul LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Type 2 diabetes mellitus, Genetic risk score, Family history
- in
- Diabetes Research and Clinical Practice
- volume
- 93
- issue
- 2
- pages
- 76 - 79
- publisher
- Elsevier
- external identifiers
-
- wos:000293825400007
- scopus:80051556037
- pmid:21570145
- ISSN
- 1872-8227
- DOI
- 10.1016/j.diabres.2011.04.013
- language
- English
- LU publication?
- yes
- id
- feda56ef-315b-4bc5-af89-874fdd5b27b8 (old id 2162097)
- date added to LUP
- 2016-04-01 11:07:11
- date last changed
- 2024-03-25 01:35:26
@article{feda56ef-315b-4bc5-af89-874fdd5b27b8, abstract = {{Objective: Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown. Methods: We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study). Results: Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend) = 0.03). The trend was similar among Framingham Offspring but was not statistically significant (p = 0.07). The meta-analyzed p value for trend from the two studies was 0.005. Conclusions: The very modest associations reported above suggest that the increased risk of diabetes in offspring of parents with diabetes is largely the result of shared environmental/lifestyle factors and/or hitherto unknown genetic factors. (C) 2011 Elsevier Ireland Ltd. All rights reserved.}}, author = {{Vassy, Jason L. and Shrader, Peter and Jonsson, Anna and Fox, Caroline S. and Lyssenko, Valeriya and Isomaa, Bo and Groop, Leif and Meigs, James B. and Franks, Paul}}, issn = {{1872-8227}}, keywords = {{Type 2 diabetes mellitus; Genetic risk score; Family history}}, language = {{eng}}, number = {{2}}, pages = {{76--79}}, publisher = {{Elsevier}}, series = {{Diabetes Research and Clinical Practice}}, title = {{Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies}}, url = {{http://dx.doi.org/10.1016/j.diabres.2011.04.013}}, doi = {{10.1016/j.diabres.2011.04.013}}, volume = {{93}}, year = {{2011}}, }