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The Associations Between Finger Length Pattern, Osteoarthritis, and Knee Injury: Data From the Framingham Community Cohort

Haugen, Ida K.; Niu, Jingbo; Aliabadi, Piran; Felson, David T. and Englund, Martin LU (2011) In Arthritis and Rheumatism 63(8). p.2284-2288
Abstract
Objective. To investigate the associations of index finger-to-ring finger (2D:4D) length ratio with radiographic knee and hand osteoarthritis (OA), previous knee injury, and meniscal lesions in the general population. Methods. We measured the length of the right second and fourth phalangeal and metacarpal bones on hand radiographs from 1,020 randomly recruited subjects (ages 51-92 years). Knee radiography and magnetic resonance imaging (MRI) were performed on subjects. Women and men were divided into tertiles according to their 2D: 4D phalangeal and metacarpal ratios. We assessed the odds ratios (ORs) and 95% confidence intervals (95% CIs) for radiographic knee OA, severe symptomatic knee OA, radiographic hand OA, previous knee injury, and... (More)
Objective. To investigate the associations of index finger-to-ring finger (2D:4D) length ratio with radiographic knee and hand osteoarthritis (OA), previous knee injury, and meniscal lesions in the general population. Methods. We measured the length of the right second and fourth phalangeal and metacarpal bones on hand radiographs from 1,020 randomly recruited subjects (ages 51-92 years). Knee radiography and magnetic resonance imaging (MRI) were performed on subjects. Women and men were divided into tertiles according to their 2D: 4D phalangeal and metacarpal ratios. We assessed the odds ratios (ORs) and 95% confidence intervals (95% CIs) for radiographic knee OA, severe symptomatic knee OA, radiographic hand OA, previous knee injury, and MRI-defined meniscal lesion, using logistic regression with adjustment for age and body mass index. Because hand OA may affect the 2D: 4D phalangeal ratio, we performed sensitivity analyses in subjects without joint space narrowing in the second and fourth interphalangeal joints. Results. We found no significant associations between 2D: 4D length ratio and radiographic knee OA, severe symptomatic knee OA, or meniscal lesions. Low 2D: 4D phalangeal ratio was associated with hand OA in women (OR 1.80, 95% CI 1.11-2.93), but in the sensitivity analysis, the association was attenuated (OR 1.35, 95% CI 0.79-2.32). Low 2D: 4D phalangeal ratios were associated with knee injury in men (OR 1.78, 95% CI 1.02-3.10). We found no significant associations for 2D:4D metacarpal ratios. Conclusion. Low 2D:4D phalangeal ratios in men are associated with knee injury, but we did not find any significant association with knee OA. Low 2D:4D length ratio may be a consequence, rather than a cause, of hand OA in women. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis and Rheumatism
volume
63
issue
8
pages
2284 - 2288
publisher
John Wiley & Sons
external identifiers
  • wos:000293840200018
  • scopus:79961122959
ISSN
1529-0131
DOI
10.1002/art.30408
language
English
LU publication?
yes
id
8bbe81ba-89cf-46b3-90fd-ad2b54a2a882 (old id 2162207)
date added to LUP
2011-10-03 08:38:54
date last changed
2017-01-01 03:02:20
@article{8bbe81ba-89cf-46b3-90fd-ad2b54a2a882,
  abstract     = {Objective. To investigate the associations of index finger-to-ring finger (2D:4D) length ratio with radiographic knee and hand osteoarthritis (OA), previous knee injury, and meniscal lesions in the general population. Methods. We measured the length of the right second and fourth phalangeal and metacarpal bones on hand radiographs from 1,020 randomly recruited subjects (ages 51-92 years). Knee radiography and magnetic resonance imaging (MRI) were performed on subjects. Women and men were divided into tertiles according to their 2D: 4D phalangeal and metacarpal ratios. We assessed the odds ratios (ORs) and 95% confidence intervals (95% CIs) for radiographic knee OA, severe symptomatic knee OA, radiographic hand OA, previous knee injury, and MRI-defined meniscal lesion, using logistic regression with adjustment for age and body mass index. Because hand OA may affect the 2D: 4D phalangeal ratio, we performed sensitivity analyses in subjects without joint space narrowing in the second and fourth interphalangeal joints. Results. We found no significant associations between 2D: 4D length ratio and radiographic knee OA, severe symptomatic knee OA, or meniscal lesions. Low 2D: 4D phalangeal ratio was associated with hand OA in women (OR 1.80, 95% CI 1.11-2.93), but in the sensitivity analysis, the association was attenuated (OR 1.35, 95% CI 0.79-2.32). Low 2D: 4D phalangeal ratios were associated with knee injury in men (OR 1.78, 95% CI 1.02-3.10). We found no significant associations for 2D:4D metacarpal ratios. Conclusion. Low 2D:4D phalangeal ratios in men are associated with knee injury, but we did not find any significant association with knee OA. Low 2D:4D length ratio may be a consequence, rather than a cause, of hand OA in women.},
  author       = {Haugen, Ida K. and Niu, Jingbo and Aliabadi, Piran and Felson, David T. and Englund, Martin},
  issn         = {1529-0131},
  language     = {eng},
  number       = {8},
  pages        = {2284--2288},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis and Rheumatism},
  title        = {The Associations Between Finger Length Pattern, Osteoarthritis, and Knee Injury: Data From the Framingham Community Cohort},
  url          = {http://dx.doi.org/10.1002/art.30408},
  volume       = {63},
  year         = {2011},
}