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Dual Metabolic Defects Are Required to Produce Hypertriglyceridemia in Obese Subjects

Taskinen, Marja-Riitta; Adiels, Martin; Westerbacka, Jukka; Soderlund, Sanni; Kahri, Juhani; Lundbom, Nina; Lundbom, Jesper; Hakkarainen, Antti; Olofsson, Sven-Olof and Orho-Melander, Marju LU , et al. (2011) In Arteriosclerosis, Thrombosis and Vascular Biology 31(9). p.556-2144
Abstract
Objective-Obesity increases the risk of cardiovascular disease and premature death. However, not all obese subjects develop the metabolic abnormalities associated with obesity. The aim of this study was to clarify the mechanisms that induce dyslipidemia in obese subjects. Methods and Results-Stable isotope tracers were used to elucidate the pathophysiology of the dyslipidemia in hypertriglyceridemic (n = 14) and normotriglyceridemic (n = 14) obese men (with comparable body mass index and visceral fat volume) and in normotriglyceridemic nonobese men (n = 10). Liver fat was determined using proton magnetic resonance spectroscopy, and subcutaneous abdominal and visceral fat were measured by magnetic resonance imaging. Serum triglycerides in... (More)
Objective-Obesity increases the risk of cardiovascular disease and premature death. However, not all obese subjects develop the metabolic abnormalities associated with obesity. The aim of this study was to clarify the mechanisms that induce dyslipidemia in obese subjects. Methods and Results-Stable isotope tracers were used to elucidate the pathophysiology of the dyslipidemia in hypertriglyceridemic (n = 14) and normotriglyceridemic (n = 14) obese men (with comparable body mass index and visceral fat volume) and in normotriglyceridemic nonobese men (n = 10). Liver fat was determined using proton magnetic resonance spectroscopy, and subcutaneous abdominal and visceral fat were measured by magnetic resonance imaging. Serum triglycerides in obese subjects were increased by the combination of increased secretion and severely impaired clearance of triglyceride-rich very-low-density lipoprotein(1) particles. Furthermore, increased liver and subcutaneous abdominal fat were linked to increased secretion of very-low-density lipoprotein 1 particles, whereas increased plasma levels of apolipoprotein C-III were associated with impaired clearance in obese hypertriglyceridemic subjects. Conclusion-Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects with similar levels of visceral adiposity. The results emphasize the clinical importance of assessing hypertriglyceridemic waist in obese subjects to identify subjects at high cardiometabolic risk. (Arterioscler Thromb Vasc Biol. 2011;31:2144-2150.) (Less)
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publication status
published
subject
keywords
apolipoproteins, lipoproteins, metabolism, obesity
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
31
issue
9
pages
556 - 2144
publisher
American Heart Association
external identifiers
  • wos:000293955200034
  • scopus:80052175601
ISSN
1524-4636
DOI
10.1161/ATVBAHA.111.224808
language
English
LU publication?
yes
id
c5dbe7d1-7304-45b8-a6d2-d60ec4df189e (old id 2162214)
date added to LUP
2011-10-03 08:40:14
date last changed
2017-11-19 03:09:36
@article{c5dbe7d1-7304-45b8-a6d2-d60ec4df189e,
  abstract     = {Objective-Obesity increases the risk of cardiovascular disease and premature death. However, not all obese subjects develop the metabolic abnormalities associated with obesity. The aim of this study was to clarify the mechanisms that induce dyslipidemia in obese subjects. Methods and Results-Stable isotope tracers were used to elucidate the pathophysiology of the dyslipidemia in hypertriglyceridemic (n = 14) and normotriglyceridemic (n = 14) obese men (with comparable body mass index and visceral fat volume) and in normotriglyceridemic nonobese men (n = 10). Liver fat was determined using proton magnetic resonance spectroscopy, and subcutaneous abdominal and visceral fat were measured by magnetic resonance imaging. Serum triglycerides in obese subjects were increased by the combination of increased secretion and severely impaired clearance of triglyceride-rich very-low-density lipoprotein(1) particles. Furthermore, increased liver and subcutaneous abdominal fat were linked to increased secretion of very-low-density lipoprotein 1 particles, whereas increased plasma levels of apolipoprotein C-III were associated with impaired clearance in obese hypertriglyceridemic subjects. Conclusion-Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects with similar levels of visceral adiposity. The results emphasize the clinical importance of assessing hypertriglyceridemic waist in obese subjects to identify subjects at high cardiometabolic risk. (Arterioscler Thromb Vasc Biol. 2011;31:2144-2150.)},
  author       = {Taskinen, Marja-Riitta and Adiels, Martin and Westerbacka, Jukka and Soderlund, Sanni and Kahri, Juhani and Lundbom, Nina and Lundbom, Jesper and Hakkarainen, Antti and Olofsson, Sven-Olof and Orho-Melander, Marju and Boren, Jan},
  issn         = {1524-4636},
  keyword      = {apolipoproteins,lipoproteins,metabolism,obesity},
  language     = {eng},
  number       = {9},
  pages        = {556--2144},
  publisher    = {American Heart Association},
  series       = {Arteriosclerosis, Thrombosis and Vascular Biology},
  title        = {Dual Metabolic Defects Are Required to Produce Hypertriglyceridemia in Obese Subjects},
  url          = {http://dx.doi.org/10.1161/ATVBAHA.111.224808},
  volume       = {31},
  year         = {2011},
}