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Health check-ups and family screening allow detection of hereditary hemochromatosis with less advanced liver fibrosis and survival comparable with the general population

Aleman, Soo; Endalib, Sanam; Stal, Per; Loof, Lars; Lindgren, Stefan LU ; Sandberg-Gertzen, Hanna; Almer, Sven; Olsson, Sigvard; Danielsson, Ake and Wallerstedt, Sven, et al. (2011) In Scandinavian Journal of Gastroenterology 46(9). p.1118-1126
Abstract
Objective. The information concerning the morbidity and mortality of hereditary hemochromatosis is based primarily on clinical cohorts of symptomatic patients. The major aim of this study was to analyze the long-term prognosis for Swedish patients with this condition, with respect to both clinical features and survival, in relation to the route by which the disease was detected. Patients and methods. 373 patients with hemochromatosis detected through routine health checkups (n = 153), family screening (n = 44), symptoms of arthralgia (n = 23), investigation of other diseases/symptoms (n = 108) or signs of liver disease (n = 45) were monitored for a mean period of 11.9 +/- 5.8 years. The degree of liver fibrosis and survival were analyzed.... (More)
Objective. The information concerning the morbidity and mortality of hereditary hemochromatosis is based primarily on clinical cohorts of symptomatic patients. The major aim of this study was to analyze the long-term prognosis for Swedish patients with this condition, with respect to both clinical features and survival, in relation to the route by which the disease was detected. Patients and methods. 373 patients with hemochromatosis detected through routine health checkups (n = 153), family screening (n = 44), symptoms of arthralgia (n = 23), investigation of other diseases/symptoms (n = 108) or signs of liver disease (n = 45) were monitored for a mean period of 11.9 +/- 5.8 years. The degree of liver fibrosis and survival were analyzed. Results. Overall survival among these patients was not significantly different from that of a matched normal population. The patients diagnosed through health check-ups and family screening were detected at an earlier age and had the highest rate of survival. Liver biopsy at the time of diagnosis revealed cirrhosis in 9% of those detected through the health check-ups and 5% in the case of family screening, compared with 13% for the group with arthralgia, 17% for other diseases/symptoms and 42% for liver disease. Conclusion. Health check-ups and family screening allow detection of hereditary hemochromatosis at an earlier age and with less advanced liver fibrosis, although a few of these patients have already developed cirrhosis. Our study indicates that iron indices should be included in health check-ups, and if abnormal, should lead to further investigation. (Less)
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Contribution to journal
publication status
published
subject
keywords
Arthralgia, cirrhosis, family screening, health checks, mortality
in
Scandinavian Journal of Gastroenterology
volume
46
issue
9
pages
1118 - 1126
publisher
Taylor & Francis
external identifiers
  • wos:000293741900014
  • scopus:80051723867
ISSN
1502-7708
DOI
10.3109/00365521.2011.591426
language
English
LU publication?
yes
id
ea90649b-681d-470a-85d4-9934bd0eb609 (old id 2162283)
date added to LUP
2011-10-03 08:41:09
date last changed
2017-08-27 04:45:37
@article{ea90649b-681d-470a-85d4-9934bd0eb609,
  abstract     = {Objective. The information concerning the morbidity and mortality of hereditary hemochromatosis is based primarily on clinical cohorts of symptomatic patients. The major aim of this study was to analyze the long-term prognosis for Swedish patients with this condition, with respect to both clinical features and survival, in relation to the route by which the disease was detected. Patients and methods. 373 patients with hemochromatosis detected through routine health checkups (n = 153), family screening (n = 44), symptoms of arthralgia (n = 23), investigation of other diseases/symptoms (n = 108) or signs of liver disease (n = 45) were monitored for a mean period of 11.9 +/- 5.8 years. The degree of liver fibrosis and survival were analyzed. Results. Overall survival among these patients was not significantly different from that of a matched normal population. The patients diagnosed through health check-ups and family screening were detected at an earlier age and had the highest rate of survival. Liver biopsy at the time of diagnosis revealed cirrhosis in 9% of those detected through the health check-ups and 5% in the case of family screening, compared with 13% for the group with arthralgia, 17% for other diseases/symptoms and 42% for liver disease. Conclusion. Health check-ups and family screening allow detection of hereditary hemochromatosis at an earlier age and with less advanced liver fibrosis, although a few of these patients have already developed cirrhosis. Our study indicates that iron indices should be included in health check-ups, and if abnormal, should lead to further investigation.},
  author       = {Aleman, Soo and Endalib, Sanam and Stal, Per and Loof, Lars and Lindgren, Stefan and Sandberg-Gertzen, Hanna and Almer, Sven and Olsson, Sigvard and Danielsson, Ake and Wallerstedt, Sven and Hultcrantz, Rolf},
  issn         = {1502-7708},
  keyword      = {Arthralgia,cirrhosis,family screening,health checks,mortality},
  language     = {eng},
  number       = {9},
  pages        = {1118--1126},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Health check-ups and family screening allow detection of hereditary hemochromatosis with less advanced liver fibrosis and survival comparable with the general population},
  url          = {http://dx.doi.org/10.3109/00365521.2011.591426},
  volume       = {46},
  year         = {2011},
}