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Quality control of 99mTc-radiopharmaceuticals - Evaluation of GCS minicolumns in routine clinical work with scintillation cameras

Darte, Lennart LU and Persson, Bertil R.R. LU (1980) In European Journal Of Nuclear Medicine 5(6). p.521-527
Abstract

Gel chromatography column scanning (GCS) is a rapid and reliable method for the quality control of 99mTc-radiopharmaceuticals. With this method the labelled compound and various impurities such as free pertechnetate, hydrolyzed reduced technetium or other 99mTc-complexes are obtained in one testing procedure. Using minicolumns results can be obtained with a simple testing procedure within a few minutes after the sample is taken; this is significant in routine radiopharmaceutical work. The resolution of the recording system is important, so as to be able to utilize fully the good separation ability of the minicolumn. Minicolumns were studied with some commonly used radiopharmaceuticals. A scintillation camera was... (More)

Gel chromatography column scanning (GCS) is a rapid and reliable method for the quality control of 99mTc-radiopharmaceuticals. With this method the labelled compound and various impurities such as free pertechnetate, hydrolyzed reduced technetium or other 99mTc-complexes are obtained in one testing procedure. Using minicolumns results can be obtained with a simple testing procedure within a few minutes after the sample is taken; this is significant in routine radiopharmaceutical work. The resolution of the recording system is important, so as to be able to utilize fully the good separation ability of the minicolumn. Minicolumns were studied with some commonly used radiopharmaceuticals. A scintillation camera was used to record minicolumn data under various conditions and the results were compared to those obtained using a scanner to reveal optimal recording conditions for the scintillation camera.

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publication status
published
subject
in
European Journal Of Nuclear Medicine
volume
5
issue
6
pages
521 - 527
publisher
Springer
external identifiers
  • pmid:7460976
  • scopus:0019227087
ISSN
0340-6997
DOI
10.1007/BF00252043
language
English
LU publication?
yes
id
21672cb4-c0eb-480b-92b9-f04f4107c4e6
date added to LUP
2020-08-15 17:25:56
date last changed
2020-08-17 12:21:58
@article{21672cb4-c0eb-480b-92b9-f04f4107c4e6,
  abstract     = {<p>Gel chromatography column scanning (GCS) is a rapid and reliable method for the quality control of <sup>99m</sup>Tc-radiopharmaceuticals. With this method the labelled compound and various impurities such as free pertechnetate, hydrolyzed reduced technetium or other <sup>99m</sup>Tc-complexes are obtained in one testing procedure. Using minicolumns results can be obtained with a simple testing procedure within a few minutes after the sample is taken; this is significant in routine radiopharmaceutical work. The resolution of the recording system is important, so as to be able to utilize fully the good separation ability of the minicolumn. Minicolumns were studied with some commonly used radiopharmaceuticals. A scintillation camera was used to record minicolumn data under various conditions and the results were compared to those obtained using a scanner to reveal optimal recording conditions for the scintillation camera.</p>},
  author       = {Darte, Lennart and Persson, Bertil R.R.},
  issn         = {0340-6997},
  language     = {eng},
  month        = {01},
  number       = {6},
  pages        = {521--527},
  publisher    = {Springer},
  series       = {European Journal Of Nuclear Medicine},
  title        = {Quality control of <sup>99m</sup>Tc-radiopharmaceuticals - Evaluation of GCS minicolumns in routine clinical work with scintillation cameras},
  url          = {http://dx.doi.org/10.1007/BF00252043},
  doi          = {10.1007/BF00252043},
  volume       = {5},
  year         = {1980},
}