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Breath alcohol analysis incorporating standardization to water vapour is as precise as blood alcohol analysis.

Grubb, David LU ; Rasmussen, B; Linnet, K; Olsson, S G and Lindberg, Lars LU (2012) In Forensic Science International 216. p.88-91
Abstract
A novel breath-alcohol analyzer based on the standardization of the breath alcohol concentration (BrAC) to the alveolar-air water vapour concentration has been developed and evaluated. The present study compares results with this particular breath analyzer with arterial blood alcohol concentrations (ABAC), the most relevant quantitative measure of brain alcohol exposure. The precision of analysis of alcohol in arterial blood and breath were determined as well as the agreement between ABAC and BrAC over time post-dosing. Twelve healthy volunteers were administered 0.6galcohol/kg bodyweight via an orogastric tube. Duplicate breath and arterial blood samples were obtained simultaneously during the absorption, distribution and elimination... (More)
A novel breath-alcohol analyzer based on the standardization of the breath alcohol concentration (BrAC) to the alveolar-air water vapour concentration has been developed and evaluated. The present study compares results with this particular breath analyzer with arterial blood alcohol concentrations (ABAC), the most relevant quantitative measure of brain alcohol exposure. The precision of analysis of alcohol in arterial blood and breath were determined as well as the agreement between ABAC and BrAC over time post-dosing. Twelve healthy volunteers were administered 0.6galcohol/kg bodyweight via an orogastric tube. Duplicate breath and arterial blood samples were obtained simultaneously during the absorption, distribution and elimination phases of the alcohol metabolism with particular emphasis on the absorption phase. The precision of the breath analyzer was similar to the determination of blood alcohol concentration by headspace gas chromatography (CV 2.40 vs. 2.38%, p=0.43). The ABAC/BrAC ratio stabilized 30min post-dosing (2089±99; mean±SD). Before this the BrAC tended to underestimate the coexisting ABAC. In conclusion, breath alcohol analysis utilizing standardization of alcohol to water vapour was as precise as blood alcohol analysis, the present "gold standard" method. The BrAC reliably predicted the coexisting ABAC from 30min onwards after the intake of alcohol. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Forensic Science International
volume
216
pages
88 - 91
publisher
Elsevier
external identifiers
  • wos:000300837000015
  • pmid:21943631
  • scopus:84857507843
ISSN
1872-6283
DOI
10.1016/j.forsciint.2011.09.001
language
English
LU publication?
yes
id
7f6ebd91-a128-4a33-973f-ed651fecd924 (old id 2168460)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21943631?dopt=Abstract
date added to LUP
2011-10-03 14:02:57
date last changed
2017-02-26 04:24:10
@article{7f6ebd91-a128-4a33-973f-ed651fecd924,
  abstract     = {A novel breath-alcohol analyzer based on the standardization of the breath alcohol concentration (BrAC) to the alveolar-air water vapour concentration has been developed and evaluated. The present study compares results with this particular breath analyzer with arterial blood alcohol concentrations (ABAC), the most relevant quantitative measure of brain alcohol exposure. The precision of analysis of alcohol in arterial blood and breath were determined as well as the agreement between ABAC and BrAC over time post-dosing. Twelve healthy volunteers were administered 0.6galcohol/kg bodyweight via an orogastric tube. Duplicate breath and arterial blood samples were obtained simultaneously during the absorption, distribution and elimination phases of the alcohol metabolism with particular emphasis on the absorption phase. The precision of the breath analyzer was similar to the determination of blood alcohol concentration by headspace gas chromatography (CV 2.40 vs. 2.38%, p=0.43). The ABAC/BrAC ratio stabilized 30min post-dosing (2089±99; mean±SD). Before this the BrAC tended to underestimate the coexisting ABAC. In conclusion, breath alcohol analysis utilizing standardization of alcohol to water vapour was as precise as blood alcohol analysis, the present "gold standard" method. The BrAC reliably predicted the coexisting ABAC from 30min onwards after the intake of alcohol.},
  author       = {Grubb, David and Rasmussen, B and Linnet, K and Olsson, S G and Lindberg, Lars},
  issn         = {1872-6283},
  language     = {eng},
  pages        = {88--91},
  publisher    = {Elsevier},
  series       = {Forensic Science International},
  title        = {Breath alcohol analysis incorporating standardization to water vapour is as precise as blood alcohol analysis.},
  url          = {http://dx.doi.org/10.1016/j.forsciint.2011.09.001},
  volume       = {216},
  year         = {2012},
}