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Evidence of a neo-sex chromosome in birds.

Pala, Irene LU ; Naurin, Sara LU ; Stervander, Martin LU ; Hasselquist, Dennis LU ; Bensch, Staffan LU and Hansson, Bengt LU (2012) In Heredity 108. p.264-272
Abstract
Neo-sex chromosomes often originate from sex chromosome-autosome fusions and constitute an important basis for the study of gene degeneration and expression in a sex chromosomal context. Neo-sex chromosomes are known from many animal and plant lineages, but have not been reported in birds, a group in which genome organization seems particularly stable. Following indications of sex linkage and unexpected sex-biased gene expression in warblers (Sylvioidea; Passeriformes), we have conducted an extensive marker analysis targeting 31 orthologues of loci on zebra finch chromosome 4a in five species, representative of independent branches of Passerida. We identified a region of sex linkage covering approximately the first half (10 Mb) of... (More)
Neo-sex chromosomes often originate from sex chromosome-autosome fusions and constitute an important basis for the study of gene degeneration and expression in a sex chromosomal context. Neo-sex chromosomes are known from many animal and plant lineages, but have not been reported in birds, a group in which genome organization seems particularly stable. Following indications of sex linkage and unexpected sex-biased gene expression in warblers (Sylvioidea; Passeriformes), we have conducted an extensive marker analysis targeting 31 orthologues of loci on zebra finch chromosome 4a in five species, representative of independent branches of Passerida. We identified a region of sex linkage covering approximately the first half (10 Mb) of chromosome 4a, and associated to both Z and W chromosomes, in three Sylvioidea passerine species. Linkage analysis in an extended pedigree of one species additionally confirmed the association between this part of chromosome 4a and the Z chromosome. Markers located between 10 and 21 Mb of chromosome 4a showed no signs of sex linkage, suggesting that only half of the chromosome was involved in this transition. No sex linkage was observed in non-Sylvioidea passerines, indicating that the neo-sex chromosome arose at the base of the Sylvioidea branch of the avian phylogeny, at 47.4-37.6 millions years ago (MYA), substantially later than the ancestral sex chromosomes (150 MYA). We hypothesize that the gene content of chromosome 4a might be relevant in its transition to a sex chromosome, based on the presence of genes (for example, the androgen receptor) that could offer a selective advantage when associated to Z-linked sex determination loci.Heredity advance online publication, 7 September 2011; doi:10.1038/hdy.2011.70. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Heredity
volume
108
pages
264 - 272
publisher
Macmillan
external identifiers
  • wos:000300596100014
  • pmid:21897438
  • scopus:84857234321
ISSN
1365-2540
DOI
10.1038/hdy.2011.70
project
Sex chromosome evolution and sex-biased expression
language
English
LU publication?
yes
id
aa0f6913-30ea-4778-a955-74f8fc69b9e3 (old id 2169089)
date added to LUP
2011-09-30 09:23:31
date last changed
2017-10-22 03:31:59
@article{aa0f6913-30ea-4778-a955-74f8fc69b9e3,
  abstract     = {Neo-sex chromosomes often originate from sex chromosome-autosome fusions and constitute an important basis for the study of gene degeneration and expression in a sex chromosomal context. Neo-sex chromosomes are known from many animal and plant lineages, but have not been reported in birds, a group in which genome organization seems particularly stable. Following indications of sex linkage and unexpected sex-biased gene expression in warblers (Sylvioidea; Passeriformes), we have conducted an extensive marker analysis targeting 31 orthologues of loci on zebra finch chromosome 4a in five species, representative of independent branches of Passerida. We identified a region of sex linkage covering approximately the first half (10 Mb) of chromosome 4a, and associated to both Z and W chromosomes, in three Sylvioidea passerine species. Linkage analysis in an extended pedigree of one species additionally confirmed the association between this part of chromosome 4a and the Z chromosome. Markers located between 10 and 21 Mb of chromosome 4a showed no signs of sex linkage, suggesting that only half of the chromosome was involved in this transition. No sex linkage was observed in non-Sylvioidea passerines, indicating that the neo-sex chromosome arose at the base of the Sylvioidea branch of the avian phylogeny, at 47.4-37.6 millions years ago (MYA), substantially later than the ancestral sex chromosomes (150 MYA). We hypothesize that the gene content of chromosome 4a might be relevant in its transition to a sex chromosome, based on the presence of genes (for example, the androgen receptor) that could offer a selective advantage when associated to Z-linked sex determination loci.Heredity advance online publication, 7 September 2011; doi:10.1038/hdy.2011.70.},
  author       = {Pala, Irene and Naurin, Sara and Stervander, Martin and Hasselquist, Dennis and Bensch, Staffan and Hansson, Bengt},
  issn         = {1365-2540},
  language     = {eng},
  pages        = {264--272},
  publisher    = {Macmillan},
  series       = {Heredity},
  title        = {Evidence of a neo-sex chromosome in birds.},
  url          = {http://dx.doi.org/10.1038/hdy.2011.70},
  volume       = {108},
  year         = {2012},
}