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Gene × Environment Interactions in Type 2 Diabetes.

Franks, Paul LU (2011) In Current Diabetes Reports
Abstract
People vary genetically in their susceptibility to the effects of environmental risk factors for many diseases. Genetic variation also underlies the extent to which people respond appropriately to clinical therapies. Defining the basis to the interactions between the genome and the environment may help elucidate the biologic basis to diseases such as type 2 diabetes, as well as help target preventive therapies and treatments. This review examines 1) some of the most current evidence on gene × environment interactions in relation to type 2 diabetes; 2) outlines how the availability of information on gene × environment interactions might help improve the prevention and treatment of type 2 diabetes; and 3) discusses existing and emerging... (More)
People vary genetically in their susceptibility to the effects of environmental risk factors for many diseases. Genetic variation also underlies the extent to which people respond appropriately to clinical therapies. Defining the basis to the interactions between the genome and the environment may help elucidate the biologic basis to diseases such as type 2 diabetes, as well as help target preventive therapies and treatments. This review examines 1) some of the most current evidence on gene × environment interactions in relation to type 2 diabetes; 2) outlines how the availability of information on gene × environment interactions might help improve the prevention and treatment of type 2 diabetes; and 3) discusses existing and emerging strategies that might enhance our ability to detect and exploit gene × environment interactions in complex disease traits. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Diabetes Reports
publisher
Current Science inc.
external identifiers
  • wos:000296512600013
  • pmid:21887612
  • scopus:80755135540
ISSN
1539-0829
DOI
10.1007/s11892-011-0224-9
language
English
LU publication?
yes
id
3cf39b53-4cc3-45f1-8128-ed3031f942b1 (old id 2169174)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21887612?dopt=Abstract
date added to LUP
2011-10-03 09:24:55
date last changed
2017-10-29 04:29:52
@article{3cf39b53-4cc3-45f1-8128-ed3031f942b1,
  abstract     = {People vary genetically in their susceptibility to the effects of environmental risk factors for many diseases. Genetic variation also underlies the extent to which people respond appropriately to clinical therapies. Defining the basis to the interactions between the genome and the environment may help elucidate the biologic basis to diseases such as type 2 diabetes, as well as help target preventive therapies and treatments. This review examines 1) some of the most current evidence on gene × environment interactions in relation to type 2 diabetes; 2) outlines how the availability of information on gene × environment interactions might help improve the prevention and treatment of type 2 diabetes; and 3) discusses existing and emerging strategies that might enhance our ability to detect and exploit gene × environment interactions in complex disease traits.},
  author       = {Franks, Paul},
  issn         = {1539-0829},
  language     = {eng},
  month        = {09},
  publisher    = {Current Science inc.},
  series       = {Current Diabetes Reports},
  title        = {Gene × Environment Interactions in Type 2 Diabetes.},
  url          = {http://dx.doi.org/10.1007/s11892-011-0224-9},
  year         = {2011},
}