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Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival

Nodin, Björn; Zendehrokh, Nooreldin LU ; Brändstedt, Jenny LU ; Nilsson, Elise LU ; Manjer, Jonas LU ; Brennan, Donal J. and Jirström, Karin LU (2010) In Journal of Ovarian Research 3.
Abstract
Background: Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear. Methods: In this study, the prognostic impact of AR expression was investigated using immunohistochemistry in tissue microarrays from 154 incident cases of epithelial ovarian cancer (EOC) in the prospective, population-based cohorts Malmo Diet and Cancer Study and Malmo Preventive Project. A subset of corresponding fallopian tubes (n = 36) with no histopathological evidence of disease was also analysed. Results: While abundantly expressed in the majority of fallopian tubes with more than 75% positive nuclei in... (More)
Background: Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear. Methods: In this study, the prognostic impact of AR expression was investigated using immunohistochemistry in tissue microarrays from 154 incident cases of epithelial ovarian cancer (EOC) in the prospective, population-based cohorts Malmo Diet and Cancer Study and Malmo Preventive Project. A subset of corresponding fallopian tubes (n = 36) with no histopathological evidence of disease was also analysed. Results: While abundantly expressed in the majority of fallopian tubes with more than 75% positive nuclei in 16/36 (44%) cases, AR was absent in 108/154 (70%) of EOC cases. AR expression was not related to prognosis in the entire cohort, but in the serous subtype (n = 90), AR positivity (> 10% positive nuclei) was associated with a prolonged disease specific survival in univariate (HR= 0.49; 95% CI 0.25- 0.96; p= 0.038) and multivariate (HR= 0.46; 95% CI 0.22-0.97; p= 0.042) analysis, adjusted for age, grade and clinical stage. Conclusions: AR expression is considerably reduced in EOC as compared to fallopian tubes, and in EOC of the serous subtype, high AR expression is a favourable prognostic factor. These results indicate that assessment of AR expression might be of value for treatment stratification of EOC patients with serous ovarian carcinoma. (Less)
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type
Contribution to journal
publication status
published
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in
Journal of Ovarian Research
volume
3
publisher
BioMed Central
external identifiers
  • wos:000295361200001
  • scopus:77954568141
ISSN
1757-2215
DOI
10.1186/1757-2215-3-14
language
English
LU publication?
yes
id
94376424-f9f2-40dd-9f75-d8a9832e5fc9 (old id 2175473)
date added to LUP
2011-11-01 07:52:11
date last changed
2018-05-29 12:31:49
@article{94376424-f9f2-40dd-9f75-d8a9832e5fc9,
  abstract     = {Background: Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear. Methods: In this study, the prognostic impact of AR expression was investigated using immunohistochemistry in tissue microarrays from 154 incident cases of epithelial ovarian cancer (EOC) in the prospective, population-based cohorts Malmo Diet and Cancer Study and Malmo Preventive Project. A subset of corresponding fallopian tubes (n = 36) with no histopathological evidence of disease was also analysed. Results: While abundantly expressed in the majority of fallopian tubes with more than 75% positive nuclei in 16/36 (44%) cases, AR was absent in 108/154 (70%) of EOC cases. AR expression was not related to prognosis in the entire cohort, but in the serous subtype (n = 90), AR positivity (> 10% positive nuclei) was associated with a prolonged disease specific survival in univariate (HR= 0.49; 95% CI 0.25- 0.96; p= 0.038) and multivariate (HR= 0.46; 95% CI 0.22-0.97; p= 0.042) analysis, adjusted for age, grade and clinical stage. Conclusions: AR expression is considerably reduced in EOC as compared to fallopian tubes, and in EOC of the serous subtype, high AR expression is a favourable prognostic factor. These results indicate that assessment of AR expression might be of value for treatment stratification of EOC patients with serous ovarian carcinoma.},
  author       = {Nodin, Björn and Zendehrokh, Nooreldin and Brändstedt, Jenny and Nilsson, Elise and Manjer, Jonas and Brennan, Donal J. and Jirström, Karin},
  issn         = {1757-2215},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Journal of Ovarian Research},
  title        = {Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival},
  url          = {http://dx.doi.org/10.1186/1757-2215-3-14},
  volume       = {3},
  year         = {2010},
}