Advanced

Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer

Stevens, Kristen N.; Vachon, Celine M.; Lee, Adam M.; Slager, Susan; Lesnick, Timothy; Olswold, Curtis; Fasching, Peter A.; Miron, Penelope; Eccles, Diana and Carpenter, Jane E., et al. (2011) In Cancer Research 71(19). p.6240-6249
Abstract
Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3),... (More)
Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer. Cancer Res; 71(19); 6240-9. (C)2011 AACR. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Research
volume
71
issue
19
pages
6240 - 6249
publisher
American Association for Cancer Research Inc.
external identifiers
  • wos:000295397700017
  • scopus:80053375835
ISSN
1538-7445
DOI
10.1158/0008-5472.CAN-11-1266
language
English
LU publication?
yes
id
17d4a50d-5191-471d-9c37-a29f10f75b76 (old id 2179532)
date added to LUP
2011-11-01 07:51:02
date last changed
2017-10-08 04:03:19
@article{17d4a50d-5191-471d-9c37-a29f10f75b76,
  abstract     = {Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer. Cancer Res; 71(19); 6240-9. (C)2011 AACR.},
  author       = {Stevens, Kristen N. and Vachon, Celine M. and Lee, Adam M. and Slager, Susan and Lesnick, Timothy and Olswold, Curtis and Fasching, Peter A. and Miron, Penelope and Eccles, Diana and Carpenter, Jane E. and Godwin, Andrew K. and Ambrosone, Christine and Winqvist, Robert and Brauch, Hiltrud and Schmidt, Marjanka K. and Cox, Angela and Cross, Simon S. and Sawyer, Elinor and Hartmann, Arndt and Beckmann, Matthias W. and Schulz-Wendtland, Ruediger and Ekici, Arif B. and Tapper, William J. and Gerty, Susan M. and Durcan, Lorraine and Graham, Nikki and Hein, Rebecca and Nickels, Stephan and Flesch-Janys, Dieter and Heinz, Judith and Sinn, Hans-Peter and Konstantopoulou, Irene and Fostira, Florentia and Pectasides, Dimitrios and Dimopoulos, Athanasios M. and Fountzilas, George and Clarke, Christine L. and Balleine, Rosemary and Olson, Janet E. and Fredericksen, Zachary and Diasio, Robert B. and Pathak, Harsh and Ross, Eric and Weaver, JoEllen and Ruediger, Thomas and Försti, Asta and Duennebier, Thomas and Ademuyiwa, Foluso and Kulkarni, Swati and Pylkaes, Katri and Jukkola-Vuorinen, Arja and Ko, Yon-Dschun and Van Limbergen, Erik and Janssen, Hilde and Peto, Julian and Fletcher, Olivia and Giles, Graham G. and Baglietto, Laura and Verhoef, Senno and Tomlinson, Ian and Kosma, Veli-Matti and Beesley, Jonathan and Greco, Dario and Blomqvist, Carl and Irwanto, Astrid and Liu, Jianjun and Blows, Fiona M. and Dawson, Sarah-Jane and Margolin, Sara and Mannermaa, Arto and Martin, Nicholas G. and Montgomery, Grant W. and Lambrechts, Diether and Silva, Isabel dos Santos and Severi, Gianluca and Hamann, Ute and Pharoah, Paul and Easton, Douglas F. and Chang-Claude, Jenny and Yannoukakos, Drakoulis and Nevanlinna, Heli and Wang, Xianshu and Couch, Fergus J.},
  issn         = {1538-7445},
  language     = {eng},
  number       = {19},
  pages        = {6240--6249},
  publisher    = {American Association for Cancer Research Inc.},
  series       = {Cancer Research},
  title        = {Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer},
  url          = {http://dx.doi.org/10.1158/0008-5472.CAN-11-1266},
  volume       = {71},
  year         = {2011},
}