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Multiscale Modeling of Insulin Secretion

Pedersen, Morten Gram LU ; Dalla Man, Chiara and Cobelli, Claudio (2011) In IEEE Transactions on Biomedical Engineering 58(10). p.3020-3023
Abstract
Insulin secretion from pancreatic beta cells is a fundamental physiological process, and its impairment plays a pivotal role in the development of diabetes. Mathematical modeling of insulin secretion has a long history, both on the level of the entire body and on the cellular and subcellular scale. However, little direct communication between these disparate scales has been included in mathematical models so far. Recently, we have proposed a minimal model for the incretin effect by which the gut hormone glucagon-like peptide 1 (GLP-1) enhances insulin secretion. To understand how this model couples to cellular events, we use a previously published mechanistic model of insulin secretion, and show mathematically that induction of glucose... (More)
Insulin secretion from pancreatic beta cells is a fundamental physiological process, and its impairment plays a pivotal role in the development of diabetes. Mathematical modeling of insulin secretion has a long history, both on the level of the entire body and on the cellular and subcellular scale. However, little direct communication between these disparate scales has been included in mathematical models so far. Recently, we have proposed a minimal model for the incretin effect by which the gut hormone glucagon-like peptide 1 (GLP-1) enhances insulin secretion. To understand how this model couples to cellular events, we use a previously published mechanistic model of insulin secretion, and show mathematically that induction of glucose competence in beta cells by GLP-1 can underlie derivative control by GLP-1. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Derivative control, glucagon-like peptide 1 (GLP-1), incretins, insulin, granules, threshold distribution
in
IEEE Transactions on Biomedical Engineering
volume
58
issue
10
pages
3020 - 3023
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
external identifiers
  • wos:000295102600021
  • scopus:80053156336
ISSN
0018-9294
DOI
10.1109/TBME.2011.2164918
language
English
LU publication?
yes
id
a52e9ef2-b895-4394-99bf-e308709354f7 (old id 2179901)
date added to LUP
2011-11-01 07:48:18
date last changed
2017-01-01 06:27:11
@article{a52e9ef2-b895-4394-99bf-e308709354f7,
  abstract     = {Insulin secretion from pancreatic beta cells is a fundamental physiological process, and its impairment plays a pivotal role in the development of diabetes. Mathematical modeling of insulin secretion has a long history, both on the level of the entire body and on the cellular and subcellular scale. However, little direct communication between these disparate scales has been included in mathematical models so far. Recently, we have proposed a minimal model for the incretin effect by which the gut hormone glucagon-like peptide 1 (GLP-1) enhances insulin secretion. To understand how this model couples to cellular events, we use a previously published mechanistic model of insulin secretion, and show mathematically that induction of glucose competence in beta cells by GLP-1 can underlie derivative control by GLP-1.},
  author       = {Pedersen, Morten Gram and Dalla Man, Chiara and Cobelli, Claudio},
  issn         = {0018-9294},
  keyword      = {Derivative control,glucagon-like peptide 1 (GLP-1),incretins,insulin,granules,threshold distribution},
  language     = {eng},
  number       = {10},
  pages        = {3020--3023},
  publisher    = {IEEE--Institute of Electrical and Electronics Engineers Inc.},
  series       = {IEEE Transactions on Biomedical Engineering},
  title        = {Multiscale Modeling of Insulin Secretion},
  url          = {http://dx.doi.org/10.1109/TBME.2011.2164918},
  volume       = {58},
  year         = {2011},
}