Advanced

Dissolution Kinetics or Pure Mass Transfer? A Mechanistic Study of Dissolution

Kaunisto, Erik LU ; Marucci, Mariagrazia LU and Axelsson, Anders LU (2011) In AICHE Journal 57(10). p.2610-2617
Abstract
In many cases, classic in vitro tests are used to investigate dissolution from powders and solids. A problem with these kinds of tests is the frequent use of agitation, leading to a lumped description of the properties at the solid-liquid intetface. The hydrodynamic forces arising from agitation might have a nontrivial impact on the dissolution properties, thus calling for a comparison of results with those stemming from stagnant dissolution with the aim to increase the understanding of the dissolution process. Stagnant dissolution of compressed solid benzoic acid was examined using the noninvasive electronic speckle pattern interferometry technique in this study. The diffusion coefficient for benzoic acid in 37 degrees C water was... (More)
In many cases, classic in vitro tests are used to investigate dissolution from powders and solids. A problem with these kinds of tests is the frequent use of agitation, leading to a lumped description of the properties at the solid-liquid intetface. The hydrodynamic forces arising from agitation might have a nontrivial impact on the dissolution properties, thus calling for a comparison of results with those stemming from stagnant dissolution with the aim to increase the understanding of the dissolution process. Stagnant dissolution of compressed solid benzoic acid was examined using the noninvasive electronic speckle pattern interferometry technique in this study. The diffusion coefficient for benzoic acid in 37 degrees C water was measured using the same technique, and, by combining the results, the surface kinetics at the solid-liquid intetface were calculated. A comparison with previous dissolution data from a rotating disk suggests that the presence of convection can increase the observed surface kinetics. (C) 2010 American Institute of Chemical Engineers AlChE J, 57: 2610-2617, 2011 (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dissolution, ESPI, benzoic acid, mass transfer, mathematical modeling
in
AICHE Journal
volume
57
issue
10
pages
2610 - 2617
publisher
Wiley-Blackwell
external identifiers
  • wos:000295154500001
  • scopus:80052610619
ISSN
1547-5905
DOI
10.1002/aic.12475
language
English
LU publication?
yes
id
185b52ad-ea03-4060-ab08-468f595f982f (old id 2180033)
date added to LUP
2011-10-25 10:24:25
date last changed
2017-10-08 03:20:49
@article{185b52ad-ea03-4060-ab08-468f595f982f,
  abstract     = {In many cases, classic in vitro tests are used to investigate dissolution from powders and solids. A problem with these kinds of tests is the frequent use of agitation, leading to a lumped description of the properties at the solid-liquid intetface. The hydrodynamic forces arising from agitation might have a nontrivial impact on the dissolution properties, thus calling for a comparison of results with those stemming from stagnant dissolution with the aim to increase the understanding of the dissolution process. Stagnant dissolution of compressed solid benzoic acid was examined using the noninvasive electronic speckle pattern interferometry technique in this study. The diffusion coefficient for benzoic acid in 37 degrees C water was measured using the same technique, and, by combining the results, the surface kinetics at the solid-liquid intetface were calculated. A comparison with previous dissolution data from a rotating disk suggests that the presence of convection can increase the observed surface kinetics. (C) 2010 American Institute of Chemical Engineers AlChE J, 57: 2610-2617, 2011},
  author       = {Kaunisto, Erik and Marucci, Mariagrazia and Axelsson, Anders},
  issn         = {1547-5905},
  keyword      = {dissolution,ESPI,benzoic acid,mass transfer,mathematical modeling},
  language     = {eng},
  number       = {10},
  pages        = {2610--2617},
  publisher    = {Wiley-Blackwell},
  series       = {AICHE Journal},
  title        = {Dissolution Kinetics or Pure Mass Transfer? A Mechanistic Study of Dissolution},
  url          = {http://dx.doi.org/10.1002/aic.12475},
  volume       = {57},
  year         = {2011},
}