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The Evolution of the Protein Corona around Nanoparticles: A Test Study

Lundqvist, Martin LU ; Stigler, Johannes; Cedervall, Tommy LU ; Berggard, Tord; Flanagan, Michelle B.; Lynch, Iseult; Elia, Giuliano and Dawson, Kenneth (2011) In ACS Nano 5(9). p.7503-7509
Abstract
The importance of the protein corona formed around nanoparticles upon entering a biological fluid has recently been highlighted. This corona is, when sufficiently long-lived, thought to govern the particles' biological fate. However, even this long-lived "hard" corona evolves and re-equilibrates as particles pass from one biological fluid to another, and may be an important feature for long-term fate. Here we show the evolution of the protein corona as a result of transfer of nanopaiticles from one biological fluid (plasma) into another (cytosolic fluid), a simple illustrative model for the uptake of nanoparticles into cells. While no direct comparison can be made to what would happen in, for example, the uptake pathway, the results... (More)
The importance of the protein corona formed around nanoparticles upon entering a biological fluid has recently been highlighted. This corona is, when sufficiently long-lived, thought to govern the particles' biological fate. However, even this long-lived "hard" corona evolves and re-equilibrates as particles pass from one biological fluid to another, and may be an important feature for long-term fate. Here we show the evolution of the protein corona as a result of transfer of nanopaiticles from one biological fluid (plasma) into another (cytosolic fluid), a simple illustrative model for the uptake of nanoparticles into cells. While no direct comparison can be made to what would happen in, for example, the uptake pathway, the results confirm that significant evolution of the corona occurs in the second biological solution, but that the final corona contains a "fingerprint" of its history. This could be evolved to map the transport pathways utilized by nanoparticles, and eventually to predict nanoparticle fate and behavior. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
protein corona, biological fluid, cytosolic fluid, nanoparticles, proteomics
in
ACS Nano
volume
5
issue
9
pages
7503 - 7509
publisher
The American Chemical Society
external identifiers
  • wos:000295187400084
  • scopus:80053313445
ISSN
1936-086X
DOI
10.1021/nn202458g
language
English
LU publication?
yes
id
90bd02b5-5df6-4dc0-8eeb-801238a49685 (old id 2180041)
date added to LUP
2011-10-25 10:27:35
date last changed
2017-11-19 03:00:49
@article{90bd02b5-5df6-4dc0-8eeb-801238a49685,
  abstract     = {The importance of the protein corona formed around nanoparticles upon entering a biological fluid has recently been highlighted. This corona is, when sufficiently long-lived, thought to govern the particles' biological fate. However, even this long-lived "hard" corona evolves and re-equilibrates as particles pass from one biological fluid to another, and may be an important feature for long-term fate. Here we show the evolution of the protein corona as a result of transfer of nanopaiticles from one biological fluid (plasma) into another (cytosolic fluid), a simple illustrative model for the uptake of nanoparticles into cells. While no direct comparison can be made to what would happen in, for example, the uptake pathway, the results confirm that significant evolution of the corona occurs in the second biological solution, but that the final corona contains a "fingerprint" of its history. This could be evolved to map the transport pathways utilized by nanoparticles, and eventually to predict nanoparticle fate and behavior.},
  author       = {Lundqvist, Martin and Stigler, Johannes and Cedervall, Tommy and Berggard, Tord and Flanagan, Michelle B. and Lynch, Iseult and Elia, Giuliano and Dawson, Kenneth},
  issn         = {1936-086X},
  keyword      = {protein corona,biological fluid,cytosolic fluid,nanoparticles,proteomics},
  language     = {eng},
  number       = {9},
  pages        = {7503--7509},
  publisher    = {The American Chemical Society},
  series       = {ACS Nano},
  title        = {The Evolution of the Protein Corona around Nanoparticles: A Test Study},
  url          = {http://dx.doi.org/10.1021/nn202458g},
  volume       = {5},
  year         = {2011},
}