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Prevalence of non-alcoholic fatty liver disease and its relation to hypoadiponectinaemia in the middle-aged and elderly Chinese population

Yang, Zhen; Wang, Xuanchun; Wen, Jie; Ye, Zi; Li, Qin; He, Min; Lu, Bin; Ling, Charlotte LU ; Wu, Songhua and Hu, Renming (2011) In Archives of Medical Science 7(4). p.665-672
Abstract
Introduction: Hypoadiponectinaemia is an important risk factor for non-alcoholic fatty liver disease (NAFLD). However, little is known about its role in the Chinese population. This study sought to assess the prevalence of NAFLD and its association with hypoadiponectinaemia in middle-aged and elderly Chinese. Material and methods: We conducted a population-based cross-sectional study in an urban Shanghai sample of 2201 participants age 50 years to 83 years (973 men, 1228 women). Hepatic ultrasonographic examination was performed for all participants. Serum adiponectin concentrations were measured by ELISA methods. Results: The prevalence of NAFLD was 19.8% (16.0% in men, 22.8% in women). Serum adiponectin levels were significantly higher... (More)
Introduction: Hypoadiponectinaemia is an important risk factor for non-alcoholic fatty liver disease (NAFLD). However, little is known about its role in the Chinese population. This study sought to assess the prevalence of NAFLD and its association with hypoadiponectinaemia in middle-aged and elderly Chinese. Material and methods: We conducted a population-based cross-sectional study in an urban Shanghai sample of 2201 participants age 50 years to 83 years (973 men, 1228 women). Hepatic ultrasonographic examination was performed for all participants. Serum adiponectin concentrations were measured by ELISA methods. Results: The prevalence of NAFLD was 19.8% (16.0% in men, 22.8% in women). Serum adiponectin levels were significantly higher in female than in male subjects (p < 0.001). Serum adiponectin levels were significantly lower in NAFLD subjects than those in control subjects (p < 0.001). The prevalence of NAFLD progressively increased with declining adiponectin levels (p(for) (trend) < 0.001). The participants in the lowest adiponectin quartile had a significantly increased risk for acquiring NAFLD (OR = 2.31, 95% CI 1.72-3.15) after adjustment for potential confounders. Conclusions: Population-based screening suggests that NAFLD is highly prevalent in middle-aged and elderly people in Shanghai, particularly among women. Serum adiponectin level is negatively associated with NAFLD independently of potential cofounders, indicating that hypoadiponectinaemia may contribute to the development of NAFLD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
non-alcoholic fatty liver disease, prevalence, risk factor, hypoadiponectinaemia
in
Archives of Medical Science
volume
7
issue
4
pages
665 - 672
publisher
Termedia Publishing House
external identifiers
  • wos:000294988300020
  • scopus:80052558297
ISSN
1734-1922
DOI
10.5114/aoms.2011.24137
language
English
LU publication?
yes
id
215fc921-6e69-46b5-aa95-19132272c09f (old id 2180244)
date added to LUP
2011-11-01 07:49:30
date last changed
2017-07-09 03:09:44
@article{215fc921-6e69-46b5-aa95-19132272c09f,
  abstract     = {Introduction: Hypoadiponectinaemia is an important risk factor for non-alcoholic fatty liver disease (NAFLD). However, little is known about its role in the Chinese population. This study sought to assess the prevalence of NAFLD and its association with hypoadiponectinaemia in middle-aged and elderly Chinese. Material and methods: We conducted a population-based cross-sectional study in an urban Shanghai sample of 2201 participants age 50 years to 83 years (973 men, 1228 women). Hepatic ultrasonographic examination was performed for all participants. Serum adiponectin concentrations were measured by ELISA methods. Results: The prevalence of NAFLD was 19.8% (16.0% in men, 22.8% in women). Serum adiponectin levels were significantly higher in female than in male subjects (p &lt; 0.001). Serum adiponectin levels were significantly lower in NAFLD subjects than those in control subjects (p &lt; 0.001). The prevalence of NAFLD progressively increased with declining adiponectin levels (p(for) (trend) &lt; 0.001). The participants in the lowest adiponectin quartile had a significantly increased risk for acquiring NAFLD (OR = 2.31, 95% CI 1.72-3.15) after adjustment for potential confounders. Conclusions: Population-based screening suggests that NAFLD is highly prevalent in middle-aged and elderly people in Shanghai, particularly among women. Serum adiponectin level is negatively associated with NAFLD independently of potential cofounders, indicating that hypoadiponectinaemia may contribute to the development of NAFLD.},
  author       = {Yang, Zhen and Wang, Xuanchun and Wen, Jie and Ye, Zi and Li, Qin and He, Min and Lu, Bin and Ling, Charlotte and Wu, Songhua and Hu, Renming},
  issn         = {1734-1922},
  keyword      = {non-alcoholic fatty liver disease,prevalence,risk factor,hypoadiponectinaemia},
  language     = {eng},
  number       = {4},
  pages        = {665--672},
  publisher    = {Termedia Publishing House},
  series       = {Archives of Medical Science},
  title        = {Prevalence of non-alcoholic fatty liver disease and its relation to hypoadiponectinaemia in the middle-aged and elderly Chinese population},
  url          = {http://dx.doi.org/10.5114/aoms.2011.24137},
  volume       = {7},
  year         = {2011},
}