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Time-dependent motor properties of multipedal molecular spiders

Samii, Laleh; Blab, Gerhard A.; Bromley, Elizabeth H. C.; Linke, Heiner LU ; Curmi, Paul M. G.; Zuckermann, Martin J. and Forde, Nancy R. (2011) In Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)2001-01-01+01:002016-01-01+01:00 84(3).
Abstract
Molecular spiders are synthetic biomolecular walkers that use the asymmetry resulting from cleavage of their tracks to bias the direction of their stepping motion. Using Monte Carlo simulations that implement the Gillespie algorithm, we investigate the dependence of the biased motion of molecular spiders, along with binding time and processivity, on tunable experimental parameters, such as number of legs, span between the legs, and unbinding rate of a leg from a substrate site. We find that an increase in the number of legs increases the spiders' processivity and binding time but not their mean velocity. However, we can increase the mean velocity of spiders with simultaneous tuning of the span and the unbinding rate of a spider leg from a... (More)
Molecular spiders are synthetic biomolecular walkers that use the asymmetry resulting from cleavage of their tracks to bias the direction of their stepping motion. Using Monte Carlo simulations that implement the Gillespie algorithm, we investigate the dependence of the biased motion of molecular spiders, along with binding time and processivity, on tunable experimental parameters, such as number of legs, span between the legs, and unbinding rate of a leg from a substrate site. We find that an increase in the number of legs increases the spiders' processivity and binding time but not their mean velocity. However, we can increase the mean velocity of spiders with simultaneous tuning of the span and the unbinding rate of a spider leg from a substrate site. To study the efficiency of molecular spiders, we introduce a time-dependent expression for the thermodynamic efficiency of a molecular motor, allowing us to account for the behavior of spider populations as a function of time. Based on this definition, we find that spiders exhibit transient motor function over time scales of many hours and have a maximum efficiency on the order of 1%, weak compared to other types of molecular motors. (Less)
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organization
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Contribution to journal
publication status
published
subject
in
Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)2001-01-01+01:002016-01-01+01:00
volume
84
issue
3
publisher
American Physical Society
external identifiers
  • wos:000294946200001
  • scopus:80053028643
ISSN
1539-3755
DOI
10.1103/PhysRevE.84.031111
language
English
LU publication?
yes
id
457a637b-4d1e-4e7d-865a-e6cf2f9de582 (old id 2180293)
date added to LUP
2011-10-25 08:52:34
date last changed
2017-01-01 03:05:09
@article{457a637b-4d1e-4e7d-865a-e6cf2f9de582,
  abstract     = {Molecular spiders are synthetic biomolecular walkers that use the asymmetry resulting from cleavage of their tracks to bias the direction of their stepping motion. Using Monte Carlo simulations that implement the Gillespie algorithm, we investigate the dependence of the biased motion of molecular spiders, along with binding time and processivity, on tunable experimental parameters, such as number of legs, span between the legs, and unbinding rate of a leg from a substrate site. We find that an increase in the number of legs increases the spiders' processivity and binding time but not their mean velocity. However, we can increase the mean velocity of spiders with simultaneous tuning of the span and the unbinding rate of a spider leg from a substrate site. To study the efficiency of molecular spiders, we introduce a time-dependent expression for the thermodynamic efficiency of a molecular motor, allowing us to account for the behavior of spider populations as a function of time. Based on this definition, we find that spiders exhibit transient motor function over time scales of many hours and have a maximum efficiency on the order of 1%, weak compared to other types of molecular motors.},
  articleno    = {031111},
  author       = {Samii, Laleh and Blab, Gerhard A. and Bromley, Elizabeth H. C. and Linke, Heiner and Curmi, Paul M. G. and Zuckermann, Martin J. and Forde, Nancy R.},
  issn         = {1539-3755},
  language     = {eng},
  number       = {3},
  publisher    = {American Physical Society},
  series       = {Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)2001-01-01+01:002016-01-01+01:00},
  title        = {Time-dependent motor properties of multipedal molecular spiders},
  url          = {http://dx.doi.org/10.1103/PhysRevE.84.031111},
  volume       = {84},
  year         = {2011},
}