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Serum gastrin and gastric enterochromaffin-like cells during estrous cycle, pregnancy and lactation, and in response to estrogen-like agents in rats

Vigen, R. A.; Chen, D.; Syversen, U.; Stunes, K.; Håkanson, Rolf LU and Zhao, C. -M. (2011) In Journal of Physiology and Pharmacology 62(3). p.335-340
Abstract
Histamine-containing enterochromaffin-like (ECL) cells are numerous in the gastric mucosa. They operate under the. control of gastrin. ECL-cell tumors (gastric carcinoids) may arise as a consequence of sustained hypergastrinemia. For reasons unknown, such tumors have a female preponderance both in laboratory animals and humans. The present study consisted of four experiments exploring the possibility that gender-related factors might affect rat ECL cells. 1) A gender difference in terms of serum gastrin concentration and oxyntic mucosal histidine decarboxylase (HDC) activity appeared in Sprague-Dawley but not Wistar rats. Ultrastructural appearance of the ECL cells did not differ between genders. 2) During the different phases of the... (More)
Histamine-containing enterochromaffin-like (ECL) cells are numerous in the gastric mucosa. They operate under the. control of gastrin. ECL-cell tumors (gastric carcinoids) may arise as a consequence of sustained hypergastrinemia. For reasons unknown, such tumors have a female preponderance both in laboratory animals and humans. The present study consisted of four experiments exploring the possibility that gender-related factors might affect rat ECL cells. 1) A gender difference in terms of serum gastrin concentration and oxyntic mucosal histidine decarboxylase (HDC) activity appeared in Sprague-Dawley but not Wistar rats. Ultrastructural appearance of the ECL cells did not differ between genders. 2) During the different phases of the estrous cycle, the serum gastrin concentration, HDC activity and histamine concentration did not change. 3) During pregnancy, the serum gastrin concentration was suppressed, while it was increased during lactation. The HDC activity and the histamine concentration of the oxyntic mucosa were correlated with the levels of circulating gastrin. 4) Twelve-month treatment with estrogen-like agents, dieldrin and/or toxaphene (alone or in combination) was without any effect on the ECL cells neither in male nor in female rats. In conclusion, the ECL cells are under the control of gastrin, but probably not hormones that involve in the estrous cycle and pregnancy and lactation in rats. Possible gender-related factors behind the female preponderance of ECL-cell tumors remain unknown. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dieldrin, histamine, enterochromaffin-like cells, gastrin, histidine, decarboxylase, lactation, pregnancy, sex, toxaphene
in
Journal of Physiology and Pharmacology
volume
62
issue
3
pages
335 - 340
publisher
Polish Physiological Society
external identifiers
  • wos:000294933000009
  • scopus:80355143528
ISSN
0867-5910
language
English
LU publication?
yes
id
66edf4d0-c897-4b94-95c9-1d61b12fc5a7 (old id 2183457)
alternative location
http://www.jpp.krakow.pl/journal/archive/06_11/.../335_06_11_article.pdf
date added to LUP
2011-11-01 07:49:55
date last changed
2017-01-01 06:08:59
@article{66edf4d0-c897-4b94-95c9-1d61b12fc5a7,
  abstract     = {Histamine-containing enterochromaffin-like (ECL) cells are numerous in the gastric mucosa. They operate under the. control of gastrin. ECL-cell tumors (gastric carcinoids) may arise as a consequence of sustained hypergastrinemia. For reasons unknown, such tumors have a female preponderance both in laboratory animals and humans. The present study consisted of four experiments exploring the possibility that gender-related factors might affect rat ECL cells. 1) A gender difference in terms of serum gastrin concentration and oxyntic mucosal histidine decarboxylase (HDC) activity appeared in Sprague-Dawley but not Wistar rats. Ultrastructural appearance of the ECL cells did not differ between genders. 2) During the different phases of the estrous cycle, the serum gastrin concentration, HDC activity and histamine concentration did not change. 3) During pregnancy, the serum gastrin concentration was suppressed, while it was increased during lactation. The HDC activity and the histamine concentration of the oxyntic mucosa were correlated with the levels of circulating gastrin. 4) Twelve-month treatment with estrogen-like agents, dieldrin and/or toxaphene (alone or in combination) was without any effect on the ECL cells neither in male nor in female rats. In conclusion, the ECL cells are under the control of gastrin, but probably not hormones that involve in the estrous cycle and pregnancy and lactation in rats. Possible gender-related factors behind the female preponderance of ECL-cell tumors remain unknown.},
  author       = {Vigen, R. A. and Chen, D. and Syversen, U. and Stunes, K. and Håkanson, Rolf and Zhao, C. -M.},
  issn         = {0867-5910},
  keyword      = {dieldrin,histamine,enterochromaffin-like cells,gastrin,histidine,decarboxylase,lactation,pregnancy,sex,toxaphene},
  language     = {eng},
  number       = {3},
  pages        = {335--340},
  publisher    = {Polish Physiological Society},
  series       = {Journal of Physiology and Pharmacology},
  title        = {Serum gastrin and gastric enterochromaffin-like cells during estrous cycle, pregnancy and lactation, and in response to estrogen-like agents in rats},
  volume       = {62},
  year         = {2011},
}