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Second-generation colon capsule endoscopy compared with colonoscopy

Spada, Cristiano; Hassan, Cesare; Munoz-Navas, Miguel; Neuhaus, Horst; Deviere, Jacques; Fockens, Paul; Coron, Emmanuel; Gay, Gerard; Toth, Ervin LU and Riccioni, Maria Elena, et al. (2011) In Gastrointestinal Endoscopy 74(3). p.581-589
Abstract
Background: Colon capsule endoscopy (CCE) represents a noninvasive technology that allows visualization of the colon without requiring sedation and air insufflation. A second-generation colon capsule endoscopy system (PillCam Colon 2) (CCE-2) was developed to increase sensitivity for colorectal polyp detection compared with the first-generation system. Objective: To assess the feasibility, accuracy, and safety of CCE-2 in a head-to-head comparison with colonoscopy. Design and Setting: Prospective, multicenter trial including 8 European sites. Patients: This study involved 117 patients (mean age 60 years). Data from 109 patients were analyzed. Intervention: CCE-2 was prospectively compared with conventional colonoscopy as the criterion... (More)
Background: Colon capsule endoscopy (CCE) represents a noninvasive technology that allows visualization of the colon without requiring sedation and air insufflation. A second-generation colon capsule endoscopy system (PillCam Colon 2) (CCE-2) was developed to increase sensitivity for colorectal polyp detection compared with the first-generation system. Objective: To assess the feasibility, accuracy, and safety of CCE-2 in a head-to-head comparison with colonoscopy. Design and Setting: Prospective, multicenter trial including 8 European sites. Patients: This study involved 117 patients (mean age 60 years). Data from 109 patients were analyzed. Intervention: CCE-2 was prospectively compared with conventional colonoscopy as the criterion standard for the detection of colorectal polyps that are >= 6 mm or masses in a cohort of patients at average or increased risk of colorectal neoplasia. Colonoscopy was independently performed within 10 hours after capsule ingestion or on the next day. Main Outcome Measurements: CCE-2 sensitivity and specificity for detecting patients with polyps >= 6 mm and >= 10 mm were assessed. Capsule-positive but colonoscopy-negative cases were counted as false positive. Capsule excretion rate, level of bowel preparation, and rate of adverse events also were assessed. Results: Per-patient CCE-2 sensitivity for polyps >= 6 mm and >= 10 mm was 84% and 88%, with specificities of 64% and 95%, respectively. All 3 invasive carcinomas were detected by CCE-2. The capsule excretion rate was 88% within 10 hours. Overall colon cleanliness for CCE-2 was adequate in 81% of patients. Limitations: Not unblinding the CCE-2 results at colonoscopy; heterogenous patient population; nonconsecutive patients. Conclusion: In this European, multicenter study, CCE-2 appeared to have a high sensitivity for the detection of clinically relevant polypoicl lesions, and it might be considered an adequate tool for colorectal imaging. (Gastrointest Enclose 201174:581-9.) (Less)
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Gastrointestinal Endoscopy
volume
74
issue
3
pages
581 - 589
publisher
Mosby
external identifiers
  • wos:000294660200019
  • scopus:80052244323
ISSN
1097-6779
DOI
10.1016/j.gie.2011.03.1125
language
English
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yes
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17d7366c-d71b-4060-a93a-9718253a6731 (old id 2186983)
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2011-11-01 07:52:48
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2017-11-12 03:41:28
@article{17d7366c-d71b-4060-a93a-9718253a6731,
  abstract     = {Background: Colon capsule endoscopy (CCE) represents a noninvasive technology that allows visualization of the colon without requiring sedation and air insufflation. A second-generation colon capsule endoscopy system (PillCam Colon 2) (CCE-2) was developed to increase sensitivity for colorectal polyp detection compared with the first-generation system. Objective: To assess the feasibility, accuracy, and safety of CCE-2 in a head-to-head comparison with colonoscopy. Design and Setting: Prospective, multicenter trial including 8 European sites. Patients: This study involved 117 patients (mean age 60 years). Data from 109 patients were analyzed. Intervention: CCE-2 was prospectively compared with conventional colonoscopy as the criterion standard for the detection of colorectal polyps that are >= 6 mm or masses in a cohort of patients at average or increased risk of colorectal neoplasia. Colonoscopy was independently performed within 10 hours after capsule ingestion or on the next day. Main Outcome Measurements: CCE-2 sensitivity and specificity for detecting patients with polyps >= 6 mm and >= 10 mm were assessed. Capsule-positive but colonoscopy-negative cases were counted as false positive. Capsule excretion rate, level of bowel preparation, and rate of adverse events also were assessed. Results: Per-patient CCE-2 sensitivity for polyps >= 6 mm and >= 10 mm was 84% and 88%, with specificities of 64% and 95%, respectively. All 3 invasive carcinomas were detected by CCE-2. The capsule excretion rate was 88% within 10 hours. Overall colon cleanliness for CCE-2 was adequate in 81% of patients. Limitations: Not unblinding the CCE-2 results at colonoscopy; heterogenous patient population; nonconsecutive patients. Conclusion: In this European, multicenter study, CCE-2 appeared to have a high sensitivity for the detection of clinically relevant polypoicl lesions, and it might be considered an adequate tool for colorectal imaging. (Gastrointest Enclose 201174:581-9.)},
  author       = {Spada, Cristiano and Hassan, Cesare and Munoz-Navas, Miguel and Neuhaus, Horst and Deviere, Jacques and Fockens, Paul and Coron, Emmanuel and Gay, Gerard and Toth, Ervin and Riccioni, Maria Elena and Carretero, Cristina and Charton, Jean P. and Van Gossum, Andre and Wientjes, Carolien A. and Sacher-Huvelin, Sylvie and Delvaux, Michel and Nemeth, Artur and Petruzziello, Lucio and Prieto de Frias, Cesar and Mayershofer, Rupert and Aminejab, Leila and Dekker, Evelien and Gahniche, Jean-Paul and Frederic, Muriel and Johansson, Gabriele Wurm and Cesaro, Paola and Costamagna, Guido},
  issn         = {1097-6779},
  language     = {eng},
  number       = {3},
  pages        = {581--589},
  publisher    = {Mosby},
  series       = {Gastrointestinal Endoscopy},
  title        = {Second-generation colon capsule endoscopy compared with colonoscopy},
  url          = {http://dx.doi.org/10.1016/j.gie.2011.03.1125},
  volume       = {74},
  year         = {2011},
}