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Survey of European Blood and Marrow Transplant (EBMT) nurses to explore the current topical skin management of chronic cutaneous graft versus host disease in the real-world clinical environment

Murray, John ; Liptrott, Sarah ; Canesi, Marta ; Mooyaart, Jarl ; Kisch, Annika LU orcid ; Piepenbroek, Brian and Stringer, Jacqui (2024) In European Journal of Oncology Nursing 69.
Abstract

Purpose: To understand the current practice in relation to the management of topical therapy for cutaneous chronic Graft versus Host Disease (ccGvHD) and access to extracorporeal photopheresis (ECP) within European allogeneic haematopoietic cell transplantation centres by a survey of nurses. Method: This was a multicentre cross-national study at eligible European Blood and Marrow Transplant centres. Eligibility required more than 30% of treated patients having allogeneic haematopoietic cell transplant. Centres performing only autologous stem cell transplants were excluded from the study. Results: 12% of respondents were unaware of whether their centre had a policy or not for monitoring chronic cutaneous graft versus host disease. Over... (More)

Purpose: To understand the current practice in relation to the management of topical therapy for cutaneous chronic Graft versus Host Disease (ccGvHD) and access to extracorporeal photopheresis (ECP) within European allogeneic haematopoietic cell transplantation centres by a survey of nurses. Method: This was a multicentre cross-national study at eligible European Blood and Marrow Transplant centres. Eligibility required more than 30% of treated patients having allogeneic haematopoietic cell transplant. Centres performing only autologous stem cell transplants were excluded from the study. Results: 12% of respondents were unaware of whether their centre had a policy or not for monitoring chronic cutaneous graft versus host disease. Over half had the affiliation of a dermatologist for referral, but only 19% had access to a specialist nurse. Patient education was routinely provided in most of the centres (86%). Results suggested as the severity of a patient's chronic cutaneous graft versus host disease increased, there was a reduction in the amount of topical emollients and steroids employed. Following topical therapies, systemic treatments, and other modalities such as ECP were employed with less focus directed towards topical care. Conclusions: Topical treatment is the backbone of any treatment paradigm for chronic cutaneous graft versus host disease, however, there is no universally agreed algorithm. Improved skin care may lead to a reduction in the amount of systemic therapy required, thus increasing patients’ quality of life. There is little standardisation in the topical management of chronic cutaneous graft versus host disease, despite skin being the most cited organ affected by chronic graft versus host disease, this should be addressed.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Allogeneic stem cell transplant, Chronic cutaneous graft versus host disease, EBMT centres, Extracorporeal photopheresis, Policy of topical therapy, Skin care, Survey of nursing staff
in
European Journal of Oncology Nursing
volume
69
article number
102547
publisher
Elsevier
external identifiers
  • scopus:85187392649
  • pmid:38467081
ISSN
1462-3889
DOI
10.1016/j.ejon.2024.102547
language
English
LU publication?
yes
id
21a0371b-c264-4bf0-ac64-3e45fb8a3f31
date added to LUP
2024-04-04 10:24:15
date last changed
2024-12-13 14:05:07
@article{21a0371b-c264-4bf0-ac64-3e45fb8a3f31,
  abstract     = {{<p>Purpose: To understand the current practice in relation to the management of topical therapy for cutaneous chronic Graft versus Host Disease (ccGvHD) and access to extracorporeal photopheresis (ECP) within European allogeneic haematopoietic cell transplantation centres by a survey of nurses. Method: This was a multicentre cross-national study at eligible European Blood and Marrow Transplant centres. Eligibility required more than 30% of treated patients having allogeneic haematopoietic cell transplant. Centres performing only autologous stem cell transplants were excluded from the study. Results: 12% of respondents were unaware of whether their centre had a policy or not for monitoring chronic cutaneous graft versus host disease. Over half had the affiliation of a dermatologist for referral, but only 19% had access to a specialist nurse. Patient education was routinely provided in most of the centres (86%). Results suggested as the severity of a patient's chronic cutaneous graft versus host disease increased, there was a reduction in the amount of topical emollients and steroids employed. Following topical therapies, systemic treatments, and other modalities such as ECP were employed with less focus directed towards topical care. Conclusions: Topical treatment is the backbone of any treatment paradigm for chronic cutaneous graft versus host disease, however, there is no universally agreed algorithm. Improved skin care may lead to a reduction in the amount of systemic therapy required, thus increasing patients’ quality of life. There is little standardisation in the topical management of chronic cutaneous graft versus host disease, despite skin being the most cited organ affected by chronic graft versus host disease, this should be addressed.</p>}},
  author       = {{Murray, John and Liptrott, Sarah and Canesi, Marta and Mooyaart, Jarl and Kisch, Annika and Piepenbroek, Brian and Stringer, Jacqui}},
  issn         = {{1462-3889}},
  keywords     = {{Allogeneic stem cell transplant; Chronic cutaneous graft versus host disease; EBMT centres; Extracorporeal photopheresis; Policy of topical therapy; Skin care; Survey of nursing staff}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Oncology Nursing}},
  title        = {{Survey of European Blood and Marrow Transplant (EBMT) nurses to explore the current topical skin management of chronic cutaneous graft versus host disease in the real-world clinical environment}},
  url          = {{http://dx.doi.org/10.1016/j.ejon.2024.102547}},
  doi          = {{10.1016/j.ejon.2024.102547}},
  volume       = {{69}},
  year         = {{2024}},
}