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Phototherapy for early-stage mycosis fungoides in thais

Sukakul, T. LU orcid ; Nitayavardhana, S. ; Janyong, N. ; Silpa-Archa, N. and Wongpraparut, C. (2019) In Journal of the Medical Association of Thailand 102(8). p.927-933
Abstract

Objective: To study the efficacy of psoralen with ultraviolet A photochemotherapy (PUVA) and narrowband ultraviolet B phototherapy (NBUVB), for early-stage mycosis fungoides (MF) in Thais. Materials and Methods: A retrospective medical chart review of 50 cases was performed. Demographic data, type of phototherapy, duration of treatments, clinical response, relapse, and adverse effects were analyzed. Comparative analysis of clinical response between hypopigmented MF and non-hypopigmented MF was performed. Results: Fifty MF patients that were stage Ia to Ila were evaluated. Fifty-four percent of patients were treated with NBUVB, 20.0% with PUVA, 6.0% with ultraviolet A1, and 20.0% with combined phototherapy. Mean treatment duration was... (More)

Objective: To study the efficacy of psoralen with ultraviolet A photochemotherapy (PUVA) and narrowband ultraviolet B phototherapy (NBUVB), for early-stage mycosis fungoides (MF) in Thais. Materials and Methods: A retrospective medical chart review of 50 cases was performed. Demographic data, type of phototherapy, duration of treatments, clinical response, relapse, and adverse effects were analyzed. Comparative analysis of clinical response between hypopigmented MF and non-hypopigmented MF was performed. Results: Fifty MF patients that were stage Ia to Ila were evaluated. Fifty-four percent of patients were treated with NBUVB, 20.0% with PUVA, 6.0% with ultraviolet A1, and 20.0% with combined phototherapy. Mean treatment duration was 7.0±2.3 months for PUVA and 7.6±4.4 months for NBUVB. Thirty patients (60.0%) had complete response and 17 (34.0%) had partial response. Clinical response between PUVA and NBUVB was not significantly different, however PUVA had less cases of relapse. Clinical response was better for hypopigmented MF patients than for non-hypopigmented MF patients. Conclusion: PUVA and NBUVB are effective and safe for early-stage MF. Hypopigmented MF had better clinical response than non-hypopigmented MF.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Asians, Mycosis fungoides, Phototherapy, Thai, Ultraviolet
in
Journal of the Medical Association of Thailand
volume
102
issue
8
pages
927 - 933
publisher
Medical Association of Thailand
external identifiers
  • scopus:85072054446
ISSN
0125-2208
language
English
LU publication?
no
additional info
Publisher Copyright: © JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND.
id
21f175b4-a1fe-449b-ba7f-e0e4ff932b50
date added to LUP
2024-07-15 14:32:54
date last changed
2024-07-16 14:15:56
@article{21f175b4-a1fe-449b-ba7f-e0e4ff932b50,
  abstract     = {{<p>Objective: To study the efficacy of psoralen with ultraviolet A photochemotherapy (PUVA) and narrowband ultraviolet B phototherapy (NBUVB), for early-stage mycosis fungoides (MF) in Thais. Materials and Methods: A retrospective medical chart review of 50 cases was performed. Demographic data, type of phototherapy, duration of treatments, clinical response, relapse, and adverse effects were analyzed. Comparative analysis of clinical response between hypopigmented MF and non-hypopigmented MF was performed. Results: Fifty MF patients that were stage Ia to Ila were evaluated. Fifty-four percent of patients were treated with NBUVB, 20.0% with PUVA, 6.0% with ultraviolet A1, and 20.0% with combined phototherapy. Mean treatment duration was 7.0±2.3 months for PUVA and 7.6±4.4 months for NBUVB. Thirty patients (60.0%) had complete response and 17 (34.0%) had partial response. Clinical response between PUVA and NBUVB was not significantly different, however PUVA had less cases of relapse. Clinical response was better for hypopigmented MF patients than for non-hypopigmented MF patients. Conclusion: PUVA and NBUVB are effective and safe for early-stage MF. Hypopigmented MF had better clinical response than non-hypopigmented MF.</p>}},
  author       = {{Sukakul, T. and Nitayavardhana, S. and Janyong, N. and Silpa-Archa, N. and Wongpraparut, C.}},
  issn         = {{0125-2208}},
  keywords     = {{Asians; Mycosis fungoides; Phototherapy; Thai; Ultraviolet}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{927--933}},
  publisher    = {{Medical Association of Thailand}},
  series       = {{Journal of the Medical Association of Thailand}},
  title        = {{Phototherapy for early-stage mycosis fungoides in thais}},
  volume       = {{102}},
  year         = {{2019}},
}