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Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire?

Norinder, Birgit Stattin; Köves, Béla LU ; Yadav, Manisha LU ; Brauner, Annelie and Svanborg, Catharina LU (2012) In Microbial Pathogenesis 52(1). p.10-16
Abstract
Bacterial virulence factors influence the site and severity of urinary tract infections. While pyelonephritis-associated molecular traits have been defined, virulence factors specific for acute cystitis strains have not been identified. This study examined the virulence factor repertoire of 247 Escherichia coli strains, prospectively isolated from women with community-acquired acute cystitis. Fim sequences were present in 96% of the isolates, which also expressed Type 1 fimbriae. Curli were detected in 75%, 13% of which formed cellulose. Pap sequences were present in 47%, 27% were papG+, 23% were prsG+ and 42% expressed P fimbriae. TcpC was expressed by 33% of the strains, 32% in a subgroup of patients who only had symptoms of cystitis and... (More)
Bacterial virulence factors influence the site and severity of urinary tract infections. While pyelonephritis-associated molecular traits have been defined, virulence factors specific for acute cystitis strains have not been identified. This study examined the virulence factor repertoire of 247 Escherichia coli strains, prospectively isolated from women with community-acquired acute cystitis. Fim sequences were present in 96% of the isolates, which also expressed Type 1 fimbriae. Curli were detected in 75%, 13% of which formed cellulose. Pap sequences were present in 47%, 27% were papG+, 23% were prsG+ and 42% expressed P fimbriae. TcpC was expressed by 33% of the strains, 32% in a subgroup of patients who only had symptoms of cystitis and 42% in patients with signs of upper urinary tract involvement; most frequently by the papG+/prsG+ subgroup. Strains with the full fim, pap and TcpC and curli virulence profile were more common in cystitis patients with than in patients without upper tract involvement (p<0.05). The varied virulence profile of E. coli strains causing acute cystitis suggests that diverse bacterial strains, expressing Type 1 fimbriae trigger a convergent host response, involving pathways that give rise to the characteristic symptoms of acute cystitis. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Microbial Pathogenesis
volume
52
issue
1
pages
10 - 16
publisher
Academic Press
external identifiers
  • wos:000299065400002
  • pmid:22023989
  • scopus:84859369590
ISSN
1096-1208
DOI
10.1016/j.micpath.2011.08.005
language
English
LU publication?
yes
id
e0ab96a8-5a8b-40df-92ce-bfc375100efd (old id 2200178)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22023989?dopt=Abstract
date added to LUP
2011-11-02 13:40:06
date last changed
2017-07-30 03:20:10
@article{e0ab96a8-5a8b-40df-92ce-bfc375100efd,
  abstract     = {Bacterial virulence factors influence the site and severity of urinary tract infections. While pyelonephritis-associated molecular traits have been defined, virulence factors specific for acute cystitis strains have not been identified. This study examined the virulence factor repertoire of 247 Escherichia coli strains, prospectively isolated from women with community-acquired acute cystitis. Fim sequences were present in 96% of the isolates, which also expressed Type 1 fimbriae. Curli were detected in 75%, 13% of which formed cellulose. Pap sequences were present in 47%, 27% were papG+, 23% were prsG+ and 42% expressed P fimbriae. TcpC was expressed by 33% of the strains, 32% in a subgroup of patients who only had symptoms of cystitis and 42% in patients with signs of upper urinary tract involvement; most frequently by the papG+/prsG+ subgroup. Strains with the full fim, pap and TcpC and curli virulence profile were more common in cystitis patients with than in patients without upper tract involvement (p&lt;0.05). The varied virulence profile of E. coli strains causing acute cystitis suggests that diverse bacterial strains, expressing Type 1 fimbriae trigger a convergent host response, involving pathways that give rise to the characteristic symptoms of acute cystitis.},
  author       = {Norinder, Birgit Stattin and Köves, Béla and Yadav, Manisha and Brauner, Annelie and Svanborg, Catharina},
  issn         = {1096-1208},
  language     = {eng},
  number       = {1},
  pages        = {10--16},
  publisher    = {Academic Press},
  series       = {Microbial Pathogenesis},
  title        = {Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire?},
  url          = {http://dx.doi.org/10.1016/j.micpath.2011.08.005},
  volume       = {52},
  year         = {2012},
}