Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire?
(2012) In Microbial Pathogenesis 52(1). p.10-16- Abstract
- Bacterial virulence factors influence the site and severity of urinary tract infections. While pyelonephritis-associated molecular traits have been defined, virulence factors specific for acute cystitis strains have not been identified. This study examined the virulence factor repertoire of 247 Escherichia coli strains, prospectively isolated from women with community-acquired acute cystitis. Fim sequences were present in 96% of the isolates, which also expressed Type 1 fimbriae. Curli were detected in 75%, 13% of which formed cellulose. Pap sequences were present in 47%, 27% were papG+, 23% were prsG+ and 42% expressed P fimbriae. TcpC was expressed by 33% of the strains, 32% in a subgroup of patients who only had symptoms of cystitis and... (More)
- Bacterial virulence factors influence the site and severity of urinary tract infections. While pyelonephritis-associated molecular traits have been defined, virulence factors specific for acute cystitis strains have not been identified. This study examined the virulence factor repertoire of 247 Escherichia coli strains, prospectively isolated from women with community-acquired acute cystitis. Fim sequences were present in 96% of the isolates, which also expressed Type 1 fimbriae. Curli were detected in 75%, 13% of which formed cellulose. Pap sequences were present in 47%, 27% were papG+, 23% were prsG+ and 42% expressed P fimbriae. TcpC was expressed by 33% of the strains, 32% in a subgroup of patients who only had symptoms of cystitis and 42% in patients with signs of upper urinary tract involvement; most frequently by the papG+/prsG+ subgroup. Strains with the full fim, pap and TcpC and curli virulence profile were more common in cystitis patients with than in patients without upper tract involvement (p<0.05). The varied virulence profile of E. coli strains causing acute cystitis suggests that diverse bacterial strains, expressing Type 1 fimbriae trigger a convergent host response, involving pathways that give rise to the characteristic symptoms of acute cystitis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2200178
- author
- Norinder, Birgit Stattin ; Köves, Béla LU ; Yadav, Manisha LU ; Brauner, Annelie and Svanborg, Catharina LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Microbial Pathogenesis
- volume
- 52
- issue
- 1
- pages
- 10 - 16
- publisher
- Academic Press
- external identifiers
-
- wos:000299065400002
- pmid:22023989
- scopus:84859369590
- pmid:22023989
- ISSN
- 1096-1208
- DOI
- 10.1016/j.micpath.2011.08.005
- language
- English
- LU publication?
- yes
- id
- e0ab96a8-5a8b-40df-92ce-bfc375100efd (old id 2200178)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22023989?dopt=Abstract
- date added to LUP
- 2016-04-01 10:43:29
- date last changed
- 2022-01-26 01:52:53
@article{e0ab96a8-5a8b-40df-92ce-bfc375100efd,
abstract = {{Bacterial virulence factors influence the site and severity of urinary tract infections. While pyelonephritis-associated molecular traits have been defined, virulence factors specific for acute cystitis strains have not been identified. This study examined the virulence factor repertoire of 247 Escherichia coli strains, prospectively isolated from women with community-acquired acute cystitis. Fim sequences were present in 96% of the isolates, which also expressed Type 1 fimbriae. Curli were detected in 75%, 13% of which formed cellulose. Pap sequences were present in 47%, 27% were papG+, 23% were prsG+ and 42% expressed P fimbriae. TcpC was expressed by 33% of the strains, 32% in a subgroup of patients who only had symptoms of cystitis and 42% in patients with signs of upper urinary tract involvement; most frequently by the papG+/prsG+ subgroup. Strains with the full fim, pap and TcpC and curli virulence profile were more common in cystitis patients with than in patients without upper tract involvement (p<0.05). The varied virulence profile of E. coli strains causing acute cystitis suggests that diverse bacterial strains, expressing Type 1 fimbriae trigger a convergent host response, involving pathways that give rise to the characteristic symptoms of acute cystitis.}},
author = {{Norinder, Birgit Stattin and Köves, Béla and Yadav, Manisha and Brauner, Annelie and Svanborg, Catharina}},
issn = {{1096-1208}},
language = {{eng}},
number = {{1}},
pages = {{10--16}},
publisher = {{Academic Press}},
series = {{Microbial Pathogenesis}},
title = {{Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire?}},
url = {{https://lup.lub.lu.se/search/files/2083955/2294118.pdf}},
doi = {{10.1016/j.micpath.2011.08.005}},
volume = {{52}},
year = {{2012}},
}