Advanced

Incidence of nephrogenic systemic fibrosis at a large university hospital in Sweden.

Alhadad, Alaa LU ; Sterner, Gunnar LU ; Svensson, Åke LU ; Alhadad, Hussein and Leander, Peter LU (2012) In Scandinavian journal of urology and nephrology 46. p.48-53
Abstract
Objective. Nephrogenic systemic fibrosis (NSF) is a rare condition that may follow administration of gadolinium-based contrast media (Gd-CM) in patients with renal insufficiency. This study was initiated to determine the incidence of NSF at Skåne University Hospital, Malmö, in Sweden. Material and methods. During the period January 2001 to December 2008 10 650 patients underwent magnetic resonance imaging (MRI) examinations. The re-expressed four-variable Modification of Diet in Renal Disease (MDRD) equation was used to calculate the estimated glomerular filtration rate (eGFR). The 272 patients with an eGFR <30 ml/min/1.73 m2 who were given Gd-CM were selected for final analysis. A diagnosis of NSF or other dermatological diagnoses in... (More)
Objective. Nephrogenic systemic fibrosis (NSF) is a rare condition that may follow administration of gadolinium-based contrast media (Gd-CM) in patients with renal insufficiency. This study was initiated to determine the incidence of NSF at Skåne University Hospital, Malmö, in Sweden. Material and methods. During the period January 2001 to December 2008 10 650 patients underwent magnetic resonance imaging (MRI) examinations. The re-expressed four-variable Modification of Diet in Renal Disease (MDRD) equation was used to calculate the estimated glomerular filtration rate (eGFR). The 272 patients with an eGFR <30 ml/min/1.73 m2 who were given Gd-CM were selected for final analysis. A diagnosis of NSF or other dermatological diagnoses in the 272 patients was searched for in the database of the Departments of Dermatology and Pathology. Results. The 272 patients, of whom 26 patients were on dialysis, had undergone 406 MRI examinations with Gd-CM. Mean follow-up time was 3.9 (±2.7 SD) years. Assuming a mean body weight of 70 kg, the overall median dose of the 406 examinations with Gd-CM was 0.14 mmol/kg body weight (0.06, 0.34; 2.5-97.5 percentiles). In this retrospective study of patients with eGFR <30 ml/min/1.73 m(2), none developed NSF (the upper 95% confidence limit for zero cases of NSF in the 272 patients was 2.3%). Conclusion. Although it is premature to claim that Gd-CM using the regimen employed in this institution is safe to use in all patients with eGFR <30 ml/min/1.73 m(2), the results.indicate that development of NSF is extremely uncommon. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian journal of urology and nephrology
volume
46
pages
48 - 53
publisher
Taylor & Francis
external identifiers
  • wos:000299125800010
  • pmid:22008005
  • scopus:84856185793
ISSN
1651-2065
DOI
10.3109/00365599.2011.621142
language
English
LU publication?
yes
id
36f53ee5-f4af-47cc-a7f7-ca723c4bdb5e (old id 2200413)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22008005?dopt=Abstract
date added to LUP
2011-11-02 10:35:22
date last changed
2017-05-28 04:37:14
@article{36f53ee5-f4af-47cc-a7f7-ca723c4bdb5e,
  abstract     = {Objective. Nephrogenic systemic fibrosis (NSF) is a rare condition that may follow administration of gadolinium-based contrast media (Gd-CM) in patients with renal insufficiency. This study was initiated to determine the incidence of NSF at Skåne University Hospital, Malmö, in Sweden. Material and methods. During the period January 2001 to December 2008 10 650 patients underwent magnetic resonance imaging (MRI) examinations. The re-expressed four-variable Modification of Diet in Renal Disease (MDRD) equation was used to calculate the estimated glomerular filtration rate (eGFR). The 272 patients with an eGFR &lt;30 ml/min/1.73 m2 who were given Gd-CM were selected for final analysis. A diagnosis of NSF or other dermatological diagnoses in the 272 patients was searched for in the database of the Departments of Dermatology and Pathology. Results. The 272 patients, of whom 26 patients were on dialysis, had undergone 406 MRI examinations with Gd-CM. Mean follow-up time was 3.9 (±2.7 SD) years. Assuming a mean body weight of 70 kg, the overall median dose of the 406 examinations with Gd-CM was 0.14 mmol/kg body weight (0.06, 0.34; 2.5-97.5 percentiles). In this retrospective study of patients with eGFR &lt;30 ml/min/1.73 m(2), none developed NSF (the upper 95% confidence limit for zero cases of NSF in the 272 patients was 2.3%). Conclusion. Although it is premature to claim that Gd-CM using the regimen employed in this institution is safe to use in all patients with eGFR &lt;30 ml/min/1.73 m(2), the results.indicate that development of NSF is extremely uncommon.},
  author       = {Alhadad, Alaa and Sterner, Gunnar and Svensson, Åke and Alhadad, Hussein and Leander, Peter},
  issn         = {1651-2065},
  language     = {eng},
  pages        = {48--53},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian journal of urology and nephrology},
  title        = {Incidence of nephrogenic systemic fibrosis at a large university hospital in Sweden.},
  url          = {http://dx.doi.org/10.3109/00365599.2011.621142},
  volume       = {46},
  year         = {2012},
}