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Cell-matrix interactions in muscle disease.

Carmignac, Virginie LU and Durbeej-Hjalt, Madeleine LU (2012) In Journal of Pathology 226. p.200-218
Abstract
The extracellular matrix provides a solid scaffold and signals to cells through extracellular matrix receptors. The cell-matrix interactions are crucial for normal biological processes and when disrupted they may lead to pathological processes. In particular, the biological importance of extracellular matrix-cell membrane-cytoskeleton interactions in skeletal muscle is accentuated by the number of inherited muscle diseases caused by mutations in proteins conferring these interactions. In this review we will introduce laminins, collagens, dystroglycan, integrins, dystrophin and sarcoglycans. Mutations in corresponding genes cause various forms of muscular dystrophy. The muscle disorders will be presented as well as advances toward... (More)
The extracellular matrix provides a solid scaffold and signals to cells through extracellular matrix receptors. The cell-matrix interactions are crucial for normal biological processes and when disrupted they may lead to pathological processes. In particular, the biological importance of extracellular matrix-cell membrane-cytoskeleton interactions in skeletal muscle is accentuated by the number of inherited muscle diseases caused by mutations in proteins conferring these interactions. In this review we will introduce laminins, collagens, dystroglycan, integrins, dystrophin and sarcoglycans. Mutations in corresponding genes cause various forms of muscular dystrophy. The muscle disorders will be presented as well as advances toward development of treatment. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Pathology
volume
226
pages
200 - 218
publisher
John Wiley & Sons
external identifiers
  • wos:000299157600006
  • pmid:21989954
  • scopus:82755181721
ISSN
0022-3417
DOI
10.1002/path.3020
language
English
LU publication?
yes
id
5d6aa4d1-8fcf-4831-9773-515b8ae65a3d (old id 2200616)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21989954?dopt=Abstract
date added to LUP
2011-11-02 09:42:12
date last changed
2017-07-09 04:34:38
@article{5d6aa4d1-8fcf-4831-9773-515b8ae65a3d,
  abstract     = {The extracellular matrix provides a solid scaffold and signals to cells through extracellular matrix receptors. The cell-matrix interactions are crucial for normal biological processes and when disrupted they may lead to pathological processes. In particular, the biological importance of extracellular matrix-cell membrane-cytoskeleton interactions in skeletal muscle is accentuated by the number of inherited muscle diseases caused by mutations in proteins conferring these interactions. In this review we will introduce laminins, collagens, dystroglycan, integrins, dystrophin and sarcoglycans. Mutations in corresponding genes cause various forms of muscular dystrophy. The muscle disorders will be presented as well as advances toward development of treatment. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.},
  author       = {Carmignac, Virginie and Durbeej-Hjalt, Madeleine},
  issn         = {0022-3417},
  language     = {eng},
  pages        = {200--218},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Pathology},
  title        = {Cell-matrix interactions in muscle disease.},
  url          = {http://dx.doi.org/10.1002/path.3020},
  volume       = {226},
  year         = {2012},
}