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Total desmosines in plasma and urine correlate with lung function.

Lindberg, C A; Engström, G; Gerhardsson de Verdier, M; Nihlén, Ulf LU ; Anderson, M; Forsman-Semb, K and Svartengren, M (2011) In European Respiratory Journal
Abstract
To evaluate the relationship between the matrix degradation biomarkers, desmosine and isodesmosine (desmosines), and lung function.Plasma and creatinine-corrected urinary total desmosines (P- and U-desmosines), lung function and carbon monoxide diffusion capacity (DL,CO) were measured in a cohort of subjects from the Swedish Twin Registry.Concentrations of U- and P-desmosines were measured in 349 and 318 subjects, respectively; approximately one-third of subjects had chronic obstructive pulmonary disease (COPD). Age, female gender, body mass index (BMI) and smoking were significantly associated with U-desmosines in a multiple linear regression analysis. In the overall population, after adjustments for age, gender, height, BMI and smoking,... (More)
To evaluate the relationship between the matrix degradation biomarkers, desmosine and isodesmosine (desmosines), and lung function.Plasma and creatinine-corrected urinary total desmosines (P- and U-desmosines), lung function and carbon monoxide diffusion capacity (DL,CO) were measured in a cohort of subjects from the Swedish Twin Registry.Concentrations of U- and P-desmosines were measured in 349 and 318 subjects, respectively; approximately one-third of subjects had chronic obstructive pulmonary disease (COPD). Age, female gender, body mass index (BMI) and smoking were significantly associated with U-desmosines in a multiple linear regression analysis. In the overall population, after adjustments for age, gender, height, BMI and smoking, concentrations of U-desmosines were significantly correlated with all lung function measures, and P-desmosines with forced expiratory volume in 1 s and DL,CO (P<0.05). With the exception of residual volume versus P-desmosines, relationships between concentrations of desmosines and lung function measures were markedly stronger in subjects with COPD compared with those without COPD.These cross-sectional data showing associations between desmosines and several lung function variables suggest that desmosines, particularly U-desmosines, could be a useful biomarker of COPD status. (Less)
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published
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European Respiratory Journal
publisher
Eur Respiratory Soc
external identifiers
  • wos:000302354900009
  • pmid:21965222
  • scopus:84860351229
ISSN
1399-3003
DOI
10.1183/09031936.00064611
language
English
LU publication?
yes
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9a3d8fd1-4359-4594-b311-6b4ab30e5591 (old id 2200887)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21965222?dopt=Abstract
date added to LUP
2011-11-01 17:41:44
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2017-11-19 04:16:38
@article{9a3d8fd1-4359-4594-b311-6b4ab30e5591,
  abstract     = {To evaluate the relationship between the matrix degradation biomarkers, desmosine and isodesmosine (desmosines), and lung function.Plasma and creatinine-corrected urinary total desmosines (P- and U-desmosines), lung function and carbon monoxide diffusion capacity (DL,CO) were measured in a cohort of subjects from the Swedish Twin Registry.Concentrations of U- and P-desmosines were measured in 349 and 318 subjects, respectively; approximately one-third of subjects had chronic obstructive pulmonary disease (COPD). Age, female gender, body mass index (BMI) and smoking were significantly associated with U-desmosines in a multiple linear regression analysis. In the overall population, after adjustments for age, gender, height, BMI and smoking, concentrations of U-desmosines were significantly correlated with all lung function measures, and P-desmosines with forced expiratory volume in 1 s and DL,CO (P&lt;0.05). With the exception of residual volume versus P-desmosines, relationships between concentrations of desmosines and lung function measures were markedly stronger in subjects with COPD compared with those without COPD.These cross-sectional data showing associations between desmosines and several lung function variables suggest that desmosines, particularly U-desmosines, could be a useful biomarker of COPD status.},
  author       = {Lindberg, C A and Engström, G and Gerhardsson de Verdier, M and Nihlén, Ulf and Anderson, M and Forsman-Semb, K and Svartengren, M},
  issn         = {1399-3003},
  language     = {eng},
  month        = {10},
  publisher    = {Eur Respiratory Soc},
  series       = {European Respiratory Journal},
  title        = {Total desmosines in plasma and urine correlate with lung function.},
  url          = {http://dx.doi.org/10.1183/09031936.00064611},
  year         = {2011},
}