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Inflammation-associated graft loss in renal transplant recipients

Dahle, Dag Olav; Mjoen, Geir; Öqvist, Björn LU ; Scharnagl, Hubert; Weihrauch, Gisela; Grammer, Tanja; Maerz, Winfried; Abedini, Sadollah; Norby, Gudrun E. and Holme, Ingar, et al. (2011) In Nephrology Dialysis Transplantation 26(11). p.3756-3761
Abstract
Background. Although short-term graft survival has improved substantially in renal transplant recipients, long-term graft survival has not improved over the last decades. The lack of knowledge of specific causes and risk factors has hampered improvements in long-term allograft survival. There is an uncertainty if inflammation is associated with late graft loss. Methods. We examined, in a large prospective trial, the inflammation markers high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) and their association with chronic graft dysfunction. We collected data from the Assessment of Lescol in Renal Transplant trial, which recruited 2102 maintenance renal transplant recipients. Results. Baseline values were hsCRP 3.8 +/- 6.7... (More)
Background. Although short-term graft survival has improved substantially in renal transplant recipients, long-term graft survival has not improved over the last decades. The lack of knowledge of specific causes and risk factors has hampered improvements in long-term allograft survival. There is an uncertainty if inflammation is associated with late graft loss. Methods. We examined, in a large prospective trial, the inflammation markers high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) and their association with chronic graft dysfunction. We collected data from the Assessment of Lescol in Renal Transplant trial, which recruited 2102 maintenance renal transplant recipients. Results. Baseline values were hsCRP 3.8 +/- 6.7 mg/L and IL-6 2.9 +/- 1.9 pg/mL. Adjusted for traditional risk factors, hsCRP and IL-6 were independently associated with death-censored graft loss, the composite end points graft loss or death and doubling of serum creatinine, graft loss or death. Conclusion. The inflammation markers hsCRP and IL-6 are associated with long-term graft outcomes in renal transplant recipients. (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
ALERT, high-sensitivity CRP, inflammation, interleukin-6, renal, allograft survival
in
Nephrology Dialysis Transplantation
volume
26
issue
11
pages
3756 - 3761
publisher
Oxford University Press
external identifiers
  • wos:000296350400053
  • scopus:80155136281
ISSN
1460-2385
DOI
10.1093/ndt/gfr163
language
English
LU publication?
yes
id
9b66d23f-2934-4940-a0f9-ea44764a1aae (old id 2207726)
date added to LUP
2011-11-30 09:12:25
date last changed
2017-04-30 12:27:29
@article{9b66d23f-2934-4940-a0f9-ea44764a1aae,
  abstract     = {Background. Although short-term graft survival has improved substantially in renal transplant recipients, long-term graft survival has not improved over the last decades. The lack of knowledge of specific causes and risk factors has hampered improvements in long-term allograft survival. There is an uncertainty if inflammation is associated with late graft loss. Methods. We examined, in a large prospective trial, the inflammation markers high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) and their association with chronic graft dysfunction. We collected data from the Assessment of Lescol in Renal Transplant trial, which recruited 2102 maintenance renal transplant recipients. Results. Baseline values were hsCRP 3.8 +/- 6.7 mg/L and IL-6 2.9 +/- 1.9 pg/mL. Adjusted for traditional risk factors, hsCRP and IL-6 were independently associated with death-censored graft loss, the composite end points graft loss or death and doubling of serum creatinine, graft loss or death. Conclusion. The inflammation markers hsCRP and IL-6 are associated with long-term graft outcomes in renal transplant recipients.},
  author       = {Dahle, Dag Olav and Mjoen, Geir and Öqvist, Björn and Scharnagl, Hubert and Weihrauch, Gisela and Grammer, Tanja and Maerz, Winfried and Abedini, Sadollah and Norby, Gudrun E. and Holme, Ingar and Fellstrom, Bengt and Jardine, Alan and Holdaas, Hallvard},
  issn         = {1460-2385},
  keyword      = {ALERT,high-sensitivity CRP,inflammation,interleukin-6,renal,allograft survival},
  language     = {eng},
  number       = {11},
  pages        = {3756--3761},
  publisher    = {Oxford University Press},
  series       = {Nephrology Dialysis Transplantation},
  title        = {Inflammation-associated graft loss in renal transplant recipients},
  url          = {http://dx.doi.org/10.1093/ndt/gfr163},
  volume       = {26},
  year         = {2011},
}