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Deteriorated function of cutaneous microcirculation in chronic congestive heart failure

Edvinsson, Marie-Louise; Uddman, Erik LU and Andersson, Sven LU (2011) In Journal of geriatric cardiology : JGC 8(2). p.82-87
Abstract
Background Chronic congestive heart failure is a complex condition that leads to dysfunction in the peripheral microcirculation. We have previously shown that vascular reactivity is reduced with increasing age. In this study, we examined a group of very old patients with severe chronic heart failure to test the hypothesis that vascular function is further compromised by a combination of heart failure and aging. Methods Cutaneous forearm blood flow was measured by laser Doppler flowmetry and compared among three groups: Group 1 (n = 20, mean +/- SE: 85.5 +/- 4 years), heart failure patients with New York Heart Association class IV (NYHA IV) and with a NT-proBNP level >= 5000 ng/L; Group 2 (n = 15, mean +/- SE: 76.5 +/- 2 years), heart... (More)
Background Chronic congestive heart failure is a complex condition that leads to dysfunction in the peripheral microcirculation. We have previously shown that vascular reactivity is reduced with increasing age. In this study, we examined a group of very old patients with severe chronic heart failure to test the hypothesis that vascular function is further compromised by a combination of heart failure and aging. Methods Cutaneous forearm blood flow was measured by laser Doppler flowmetry and compared among three groups: Group 1 (n = 20, mean +/- SE: 85.5 +/- 4 years), heart failure patients with New York Heart Association class IV (NYHA IV) and with a NT-proBNP level >= 5000 ng/L; Group 2 (n = 15, mean +/- SE: 76.5 +/- 2 years), heart failure patients with NYHA II and NT-proBNP <= 2000 ng/L, and Group 3 (n = 10, mean +/- SE: 67.6 +/- 3.0 years), healthy controls with no clinical signs of heart failure. The vasodilator response to the iontophoretic administration of acetylcholine (ACh), acting via an endothelial mechanism, and sodium nitroprusside (SNP), acting via a smooth muscle cell mechanism, were studied. Results All patients with heart failure had significantly reduced vascular reactivity independent of the mode of stimulation (ACh, SNP or heat) when compared to healthy controls. However, the responses did not differ between the two groups of heart failure patients. Conclusions Cutaneous vascular reactivity is reduced in heart failure patients and does not correlate with the severity of the condition or age of patients. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
heart failure, cutaneous microcirculation, endothelial responses, acetylcholine, smooth muscle responses
in
Journal of geriatric cardiology : JGC
volume
8
issue
2
pages
82 - 87
publisher
Science Press
external identifiers
  • wos:000296323500004
  • scopus:79960027292
ISSN
1671-5411
DOI
10.3724/SP.J.1263.2011.00082
language
English
LU publication?
yes
id
ded2abf1-da58-43ff-9ca7-a1c867786970 (old id 2207808)
date added to LUP
2011-11-30 09:13:12
date last changed
2017-05-28 04:12:20
@article{ded2abf1-da58-43ff-9ca7-a1c867786970,
  abstract     = {Background Chronic congestive heart failure is a complex condition that leads to dysfunction in the peripheral microcirculation. We have previously shown that vascular reactivity is reduced with increasing age. In this study, we examined a group of very old patients with severe chronic heart failure to test the hypothesis that vascular function is further compromised by a combination of heart failure and aging. Methods Cutaneous forearm blood flow was measured by laser Doppler flowmetry and compared among three groups: Group 1 (n = 20, mean +/- SE: 85.5 +/- 4 years), heart failure patients with New York Heart Association class IV (NYHA IV) and with a NT-proBNP level &gt;= 5000 ng/L; Group 2 (n = 15, mean +/- SE: 76.5 +/- 2 years), heart failure patients with NYHA II and NT-proBNP &lt;= 2000 ng/L, and Group 3 (n = 10, mean +/- SE: 67.6 +/- 3.0 years), healthy controls with no clinical signs of heart failure. The vasodilator response to the iontophoretic administration of acetylcholine (ACh), acting via an endothelial mechanism, and sodium nitroprusside (SNP), acting via a smooth muscle cell mechanism, were studied. Results All patients with heart failure had significantly reduced vascular reactivity independent of the mode of stimulation (ACh, SNP or heat) when compared to healthy controls. However, the responses did not differ between the two groups of heart failure patients. Conclusions Cutaneous vascular reactivity is reduced in heart failure patients and does not correlate with the severity of the condition or age of patients.},
  author       = {Edvinsson, Marie-Louise and Uddman, Erik and Andersson, Sven},
  issn         = {1671-5411},
  keyword      = {heart failure,cutaneous microcirculation,endothelial responses,acetylcholine,smooth muscle responses},
  language     = {eng},
  number       = {2},
  pages        = {82--87},
  publisher    = {Science Press},
  series       = {Journal of geriatric cardiology : JGC},
  title        = {Deteriorated function of cutaneous microcirculation in chronic congestive heart failure},
  url          = {http://dx.doi.org/10.3724/SP.J.1263.2011.00082},
  volume       = {8},
  year         = {2011},
}