The executioners sing a new song: killer caspases activate microglia
(2011) In Cell Death and Differentiation 18(11). p.1679-1691- Abstract
- Activation of microglia and inflammation-mediated neurotoxicity are suggested to have key roles in the pathogenesis of several neurodegenerative disorders. We recently published an article in Nature revealing an unexpected role for executioner caspases in the microglia activation process. We showed that caspases 8 and 3/7, commonly known to have executioner roles for apoptosis, can promote microglia activation in the absence of death. We found these caspases to be activated in microglia of PD and AD subjects. Inhibition of this signaling pathway hindered microglia activation and importantly reduced neurotoxicity in cell and animal models of disease. Here we review evidence suggesting that microglia can have a key role in the pathology of... (More)
- Activation of microglia and inflammation-mediated neurotoxicity are suggested to have key roles in the pathogenesis of several neurodegenerative disorders. We recently published an article in Nature revealing an unexpected role for executioner caspases in the microglia activation process. We showed that caspases 8 and 3/7, commonly known to have executioner roles for apoptosis, can promote microglia activation in the absence of death. We found these caspases to be activated in microglia of PD and AD subjects. Inhibition of this signaling pathway hindered microglia activation and importantly reduced neurotoxicity in cell and animal models of disease. Here we review evidence suggesting that microglia can have a key role in the pathology of neurodegenerative disorders. We discuss possible underlying mechanisms regulating their activation and neurotoxic effect. We focus on the provocative hypothesis that caspase inhibition can be neuroprotective by targeting the microglia rather than the neurons themselves. Cell Death and Differentiation (2011) 18, 1679-1691; doi: 10.1038/cdd.2011.107; published online 12 August 2011 (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2212068
- author
- Venero, J. L. ; Burguillos Garcia, Miguel LU ; Brundin, Patrik LU and Joseph, B.
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- microglia, caspases, neurodegenerative disorders
- in
- Cell Death and Differentiation
- volume
- 18
- issue
- 11
- pages
- 1679 - 1691
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000295929600001
- scopus:81155161863
- pmid:21836616
- ISSN
- 1350-9047
- DOI
- 10.1038/cdd.2011.107
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
- id
- 3030011a-f38c-469a-9beb-59990f6143b4 (old id 2212068)
- date added to LUP
- 2016-04-01 10:14:01
- date last changed
- 2022-01-25 21:05:30
@article{3030011a-f38c-469a-9beb-59990f6143b4,
abstract = {{Activation of microglia and inflammation-mediated neurotoxicity are suggested to have key roles in the pathogenesis of several neurodegenerative disorders. We recently published an article in Nature revealing an unexpected role for executioner caspases in the microglia activation process. We showed that caspases 8 and 3/7, commonly known to have executioner roles for apoptosis, can promote microglia activation in the absence of death. We found these caspases to be activated in microglia of PD and AD subjects. Inhibition of this signaling pathway hindered microglia activation and importantly reduced neurotoxicity in cell and animal models of disease. Here we review evidence suggesting that microglia can have a key role in the pathology of neurodegenerative disorders. We discuss possible underlying mechanisms regulating their activation and neurotoxic effect. We focus on the provocative hypothesis that caspase inhibition can be neuroprotective by targeting the microglia rather than the neurons themselves. Cell Death and Differentiation (2011) 18, 1679-1691; doi: 10.1038/cdd.2011.107; published online 12 August 2011}},
author = {{Venero, J. L. and Burguillos Garcia, Miguel and Brundin, Patrik and Joseph, B.}},
issn = {{1350-9047}},
keywords = {{microglia; caspases; neurodegenerative disorders}},
language = {{eng}},
number = {{11}},
pages = {{1679--1691}},
publisher = {{Nature Publishing Group}},
series = {{Cell Death and Differentiation}},
title = {{The executioners sing a new song: killer caspases activate microglia}},
url = {{http://dx.doi.org/10.1038/cdd.2011.107}},
doi = {{10.1038/cdd.2011.107}},
volume = {{18}},
year = {{2011}},
}