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Soluble urokinase plasminogen activator receptor in plasma is associated with incidence of CVD. Results from the Malmö Diet and Cancer Study.

Persson, Margaretha LU ; Engström, Gunnar LU ; Björkbacka, Harry LU and Hedblad, Bo LU (2012) In Atherosclerosis 220(2). p.502-505
Abstract
BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a highly sensitive marker that reflects increased inflammation and is positively correlated with pro-inflammatory biomarkers. The aim of this study was to explore the relationship between suPAR, cardiovascular disease (CVD) risk factors and incidence of CVD. METHODS: suPAR was assessed in a random sample of participants (N=569), aged 63-68 years (mean age 65.5), from the Malmö Diet and Cancer Study (MDCS) cardiovascular cohort. Baseline examination was conducted between 1991 and 1994. suPAR in blood was analysed using a commercially available assay (suPARnostic). Cox regression analysis was used to investigate the incidence of CVD (coronary events or ischemic stroke),... (More)
BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a highly sensitive marker that reflects increased inflammation and is positively correlated with pro-inflammatory biomarkers. The aim of this study was to explore the relationship between suPAR, cardiovascular disease (CVD) risk factors and incidence of CVD. METHODS: suPAR was assessed in a random sample of participants (N=569), aged 63-68 years (mean age 65.5), from the Malmö Diet and Cancer Study (MDCS) cardiovascular cohort. Baseline examination was conducted between 1991 and 1994. suPAR in blood was analysed using a commercially available assay (suPARnostic). Cox regression analysis was used to investigate the incidence of CVD (coronary events or ischemic stroke), in relation to sex-specific tertiles of suPAR. RESULTS: Significantly higher plasma levels of suPAR was found in women, smokers, diabetics and older subjects. suPAR was significantly positively correlated with markers of systemic inflammation (i.e., high sensitive C-reactive protein (hsCRP) and white blood cells (WBC), but not to lipoprotein-associated phospholipase A2 (Lp-PLA(2)), a specific vascular inflammatory biomarker.87 subjects had a CVD event during follow-up (mean 14.1 years). In an age/sex-adjusted model, the hazard ratio (HR) for incident CVD was 2.53 (95%CI: 1.44-4.46) for the top compared to the bottom tertile of suPAR. This association remained significant after further adjustment for smoking, low density lipoprotein (LDL), systolic blood pressure, use of anti-hypertensive medication, diabetes, hsCRP, WBC and Lp-PLA(2) (HR: 2.25; 1.07-4.72). CONCLUSION: Elevated levels of suPAR are, independently of established cardiovascular risk factors, associated with an increased incidence of CVD in elderly subjects. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Atherosclerosis
volume
220
issue
2
pages
502 - 505
publisher
Elsevier
external identifiers
  • wos:000299319100034
  • pmid:22119508
  • scopus:84855940788
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2011.10.039
language
English
LU publication?
yes
id
01f68ab9-7456-4a93-bb19-bc7e0148ba7a (old id 2220302)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22119508?dopt=Abstract
date added to LUP
2011-12-03 10:26:13
date last changed
2017-11-05 03:07:59
@article{01f68ab9-7456-4a93-bb19-bc7e0148ba7a,
  abstract     = {BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a highly sensitive marker that reflects increased inflammation and is positively correlated with pro-inflammatory biomarkers. The aim of this study was to explore the relationship between suPAR, cardiovascular disease (CVD) risk factors and incidence of CVD. METHODS: suPAR was assessed in a random sample of participants (N=569), aged 63-68 years (mean age 65.5), from the Malmö Diet and Cancer Study (MDCS) cardiovascular cohort. Baseline examination was conducted between 1991 and 1994. suPAR in blood was analysed using a commercially available assay (suPARnostic). Cox regression analysis was used to investigate the incidence of CVD (coronary events or ischemic stroke), in relation to sex-specific tertiles of suPAR. RESULTS: Significantly higher plasma levels of suPAR was found in women, smokers, diabetics and older subjects. suPAR was significantly positively correlated with markers of systemic inflammation (i.e., high sensitive C-reactive protein (hsCRP) and white blood cells (WBC), but not to lipoprotein-associated phospholipase A2 (Lp-PLA(2)), a specific vascular inflammatory biomarker.87 subjects had a CVD event during follow-up (mean 14.1 years). In an age/sex-adjusted model, the hazard ratio (HR) for incident CVD was 2.53 (95%CI: 1.44-4.46) for the top compared to the bottom tertile of suPAR. This association remained significant after further adjustment for smoking, low density lipoprotein (LDL), systolic blood pressure, use of anti-hypertensive medication, diabetes, hsCRP, WBC and Lp-PLA(2) (HR: 2.25; 1.07-4.72). CONCLUSION: Elevated levels of suPAR are, independently of established cardiovascular risk factors, associated with an increased incidence of CVD in elderly subjects.},
  author       = {Persson, Margaretha and Engström, Gunnar and Björkbacka, Harry and Hedblad, Bo},
  issn         = {1879-1484},
  language     = {eng},
  number       = {2},
  pages        = {502--505},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Soluble urokinase plasminogen activator receptor in plasma is associated with incidence of CVD. Results from the Malmö Diet and Cancer Study.},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2011.10.039},
  volume       = {220},
  year         = {2012},
}