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Can Parkinson's disease pathology be propagated from one neuron to another?

Dunning, Christopher LU ; Reyes, Juan F LU ; Steiner, Jennifer LU and Brundin, Patrik LU (2012) In Progress in Neurobiology 97. p.205-219
Abstract
Parkinson's disease is the second most prevalent neurodegenerative disease, yet despite this, very little is known about the underlying cellular mechanisms. Initially it was thought to be a disease primarily involving loss of dopaminergic neurons in the substantia nigra pars compacta. Recent studies, however, have focused on observations that aggregated α-synuclein protein, the major component of Lewy bodies, is found throughout the nervous system. It is speculated that misfolded α-synuclein transfers between cells in a prion-like manner, thereby mediating the spread of the neuropathology. In this review, we discuss the staging (according to Braak) of Parkinson pathology and the concept describing the disease progression from one region of... (More)
Parkinson's disease is the second most prevalent neurodegenerative disease, yet despite this, very little is known about the underlying cellular mechanisms. Initially it was thought to be a disease primarily involving loss of dopaminergic neurons in the substantia nigra pars compacta. Recent studies, however, have focused on observations that aggregated α-synuclein protein, the major component of Lewy bodies, is found throughout the nervous system. It is speculated that misfolded α-synuclein transfers between cells in a prion-like manner, thereby mediating the spread of the neuropathology. In this review, we discuss the staging (according to Braak) of Parkinson pathology and the concept describing the disease progression from one region of the brain to the other. We highlight how α-synuclein might be responsible for the spread of the disease. We compare the idea of a prion-like mechanism contributing to Parkinson's disease to emerging concepts that other proteins participate in similar processes in other neurodegenerative diseases. We then examine the future implications of a critical role in disease pathogenesis of α-synuclein for the classification, diagnosis and treatment of Parkinson's disease in the future. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Progress in Neurobiology
volume
97
pages
205 - 219
publisher
Elsevier
external identifiers
  • wos:000304796100011
  • pmid:22115849
  • scopus:84860686110
ISSN
1873-5118
DOI
10.1016/j.pneurobio.2011.11.003
language
English
LU publication?
yes
id
0bfc1b76-1af6-4a69-b374-eb2e3861462b (old id 2220348)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22115849?dopt=Abstract
date added to LUP
2011-12-03 10:18:15
date last changed
2017-09-10 03:16:56
@article{0bfc1b76-1af6-4a69-b374-eb2e3861462b,
  abstract     = {Parkinson's disease is the second most prevalent neurodegenerative disease, yet despite this, very little is known about the underlying cellular mechanisms. Initially it was thought to be a disease primarily involving loss of dopaminergic neurons in the substantia nigra pars compacta. Recent studies, however, have focused on observations that aggregated α-synuclein protein, the major component of Lewy bodies, is found throughout the nervous system. It is speculated that misfolded α-synuclein transfers between cells in a prion-like manner, thereby mediating the spread of the neuropathology. In this review, we discuss the staging (according to Braak) of Parkinson pathology and the concept describing the disease progression from one region of the brain to the other. We highlight how α-synuclein might be responsible for the spread of the disease. We compare the idea of a prion-like mechanism contributing to Parkinson's disease to emerging concepts that other proteins participate in similar processes in other neurodegenerative diseases. We then examine the future implications of a critical role in disease pathogenesis of α-synuclein for the classification, diagnosis and treatment of Parkinson's disease in the future.},
  author       = {Dunning, Christopher and Reyes, Juan F and Steiner, Jennifer and Brundin, Patrik},
  issn         = {1873-5118},
  language     = {eng},
  pages        = {205--219},
  publisher    = {Elsevier},
  series       = {Progress in Neurobiology},
  title        = {Can Parkinson's disease pathology be propagated from one neuron to another?},
  url          = {http://dx.doi.org/10.1016/j.pneurobio.2011.11.003},
  volume       = {97},
  year         = {2012},
}