Advanced

Glycoprotein 340 and sialic acid in minor-gland and whole saliva of children, adolescents, and adults.

Sonesson, Mikael; Ericson, Dan; Kinnby, Bertil and Wickström, Claes LU (2011) In European Journal of Oral Sciences 119(6). p.435-440
Abstract
Glycoprotein 340 (gp-340) is a bacterial-binding glycoprotein found in major-gland and minor-gland saliva. Sialic acid, a common terminal structure of salivary glycoproteins, interacts with microorganisms and host ligands, as well as with free radicals. This study investigated the contents of gp-340 and sialic acid in minor-gland saliva and whole saliva of children (3 yr of age), adolescents (14 yr of age), and adults (20-25 yr of age). Labial-gland saliva and buccal-gland saliva were collected on filter paper, and unstimulated whole saliva was collected by draining into a tube. The relative amount of gp-340 and sialic acid was determined by ELISA and by enzyme-linked lectin assay (ELLA), respectively. In minor-gland saliva, no... (More)
Glycoprotein 340 (gp-340) is a bacterial-binding glycoprotein found in major-gland and minor-gland saliva. Sialic acid, a common terminal structure of salivary glycoproteins, interacts with microorganisms and host ligands, as well as with free radicals. This study investigated the contents of gp-340 and sialic acid in minor-gland saliva and whole saliva of children (3 yr of age), adolescents (14 yr of age), and adults (20-25 yr of age). Labial-gland saliva and buccal-gland saliva were collected on filter paper, and unstimulated whole saliva was collected by draining into a tube. The relative amount of gp-340 and sialic acid was determined by ELISA and by enzyme-linked lectin assay (ELLA), respectively. In minor-gland saliva, no statistically significant differences in gp-340 and sialic acid were seen between the age-groups. Among adults, significantly lower amounts of gp-340 and sialic acid were seen in labial saliva compared with buccal saliva. In whole saliva, the amount of gp-340 was significantly lower among adults compared with children. No differences between genders were seen. Stable content of gp-340 and sialic acid in minor-gland saliva across the age-groups, and a higher content of gp-340 in the whole saliva of the youngest age-group (3-yr-olds) compared with the adult group, may reflect that those components are vital innate factors of immunity in children's saliva. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Oral Sciences
volume
119
issue
6
pages
435 - 440
publisher
Wiley-Blackwell
external identifiers
  • pmid:22112028
  • scopus:82155165897
ISSN
0909-8836
DOI
10.1111/j.1600-0722.2011.00879.x
language
English
LU publication?
yes
id
46b07819-59f7-48b4-a367-0d3fb9de47de (old id 2220437)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22112028?dopt=Abstract
date added to LUP
2011-12-03 09:50:50
date last changed
2017-10-22 04:51:32
@article{46b07819-59f7-48b4-a367-0d3fb9de47de,
  abstract     = {Glycoprotein 340 (gp-340) is a bacterial-binding glycoprotein found in major-gland and minor-gland saliva. Sialic acid, a common terminal structure of salivary glycoproteins, interacts with microorganisms and host ligands, as well as with free radicals. This study investigated the contents of gp-340 and sialic acid in minor-gland saliva and whole saliva of children (3 yr of age), adolescents (14 yr of age), and adults (20-25 yr of age). Labial-gland saliva and buccal-gland saliva were collected on filter paper, and unstimulated whole saliva was collected by draining into a tube. The relative amount of gp-340 and sialic acid was determined by ELISA and by enzyme-linked lectin assay (ELLA), respectively. In minor-gland saliva, no statistically significant differences in gp-340 and sialic acid were seen between the age-groups. Among adults, significantly lower amounts of gp-340 and sialic acid were seen in labial saliva compared with buccal saliva. In whole saliva, the amount of gp-340 was significantly lower among adults compared with children. No differences between genders were seen. Stable content of gp-340 and sialic acid in minor-gland saliva across the age-groups, and a higher content of gp-340 in the whole saliva of the youngest age-group (3-yr-olds) compared with the adult group, may reflect that those components are vital innate factors of immunity in children's saliva.},
  author       = {Sonesson, Mikael and Ericson, Dan and Kinnby, Bertil and Wickström, Claes},
  issn         = {0909-8836},
  language     = {eng},
  number       = {6},
  pages        = {435--440},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Oral Sciences},
  title        = {Glycoprotein 340 and sialic acid in minor-gland and whole saliva of children, adolescents, and adults.},
  url          = {http://dx.doi.org/10.1111/j.1600-0722.2011.00879.x},
  volume       = {119},
  year         = {2011},
}