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Phagocytic properties in tumor astrocytes.

Persson, Annette LU and Englund, Elisabet LU (2012) In Neuropathology 32. p.252-260
Abstract
In glioblastoma multiforme (GBM), the pathophysiological events preceding and promoting an uncontrolled and remarkable growth is largely unknown. Studies on gliomas and macrophage expression have shown high levels of phagocytic cells, that is, microglial cells. It has also been demonstrated that human astrocytic cells and rat glioma cells are capable of phagocytosis. The purpose of this study was to investigate a potential phagocytic property in human GBM cells in tumor biopsies from surgery. With an immunhistochemical double staining using macrophage markers (CD68 and CD163) and human telomerase reverse transcriptase (hTERT) as a marker for neoplastic cells, we found high levels of double positive cells in human GBM. In... (More)
In glioblastoma multiforme (GBM), the pathophysiological events preceding and promoting an uncontrolled and remarkable growth is largely unknown. Studies on gliomas and macrophage expression have shown high levels of phagocytic cells, that is, microglial cells. It has also been demonstrated that human astrocytic cells and rat glioma cells are capable of phagocytosis. The purpose of this study was to investigate a potential phagocytic property in human GBM cells in tumor biopsies from surgery. With an immunhistochemical double staining using macrophage markers (CD68 and CD163) and human telomerase reverse transcriptase (hTERT) as a marker for neoplastic cells, we found high levels of double positive cells in human GBM. In hematoxylin-erythrosin stained sections, we also identified fragmented cell components in the cytoplasm of tumor cells. In our judgement, many neoplastic cells in GBM are also positive for macrophage markers. We suggest that human astroglial tumor cells may have phagocytic properties or phagocyte-like properties. This may represent a latent capacity of self-defence, evoked under certain circumstances. It is likely that these properties substantially help the tumors thrive and expand. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuropathology
volume
32
pages
252 - 260
publisher
Wiley-Blackwell
external identifiers
  • wos:000304446800005
  • pmid:22098621
  • scopus:84861528702
ISSN
0919-6544
DOI
10.1111/j.1440-1789.2011.01266.x
language
English
LU publication?
yes
id
eb640428-50fb-4771-86f7-520cace6eaac (old id 2220618)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22098621?dopt=Abstract
date added to LUP
2011-12-02 22:23:26
date last changed
2017-01-01 07:31:22
@article{eb640428-50fb-4771-86f7-520cace6eaac,
  abstract     = {In glioblastoma multiforme (GBM), the pathophysiological events preceding and promoting an uncontrolled and remarkable growth is largely unknown. Studies on gliomas and macrophage expression have shown high levels of phagocytic cells, that is, microglial cells. It has also been demonstrated that human astrocytic cells and rat glioma cells are capable of phagocytosis. The purpose of this study was to investigate a potential phagocytic property in human GBM cells in tumor biopsies from surgery. With an immunhistochemical double staining using macrophage markers (CD68 and CD163) and human telomerase reverse transcriptase (hTERT) as a marker for neoplastic cells, we found high levels of double positive cells in human GBM. In hematoxylin-erythrosin stained sections, we also identified fragmented cell components in the cytoplasm of tumor cells. In our judgement, many neoplastic cells in GBM are also positive for macrophage markers. We suggest that human astroglial tumor cells may have phagocytic properties or phagocyte-like properties. This may represent a latent capacity of self-defence, evoked under certain circumstances. It is likely that these properties substantially help the tumors thrive and expand.},
  author       = {Persson, Annette and Englund, Elisabet},
  issn         = {0919-6544},
  language     = {eng},
  pages        = {252--260},
  publisher    = {Wiley-Blackwell},
  series       = {Neuropathology},
  title        = {Phagocytic properties in tumor astrocytes.},
  url          = {http://dx.doi.org/10.1111/j.1440-1789.2011.01266.x},
  volume       = {32},
  year         = {2012},
}