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Optimization of preparative chromatographic separation of multiple rare earth elements.

Max-Hansen, Mark LU ; Ojala, Frida LU ; Kifle, Dejene; Borg, Niklas LU and Nilsson, Bernt LU (2011) In Journal of Chromatography A 1218(51). p.9155-9161
Abstract
This work presents a method to optimize multi-product chromatographic systems with multiple objective functions. The system studied is a neodymium, samarium, europium, gadolinium mixture separated in an ion exchange chromatography step. A homogeneous Langmuir Mobile Phase Modified model is calibrated to fit the experiments, and then used to perform the optimization task. For the optimization a multi-objective Differential Evolution algorithm was used, with weighting based on relative value of the components to find optimal operation points along the Pareto front. The objectives of the Pareto front are weighted productivity and weighted yield with purity as an equality constraint. A prioritizing scheme based on relative values is applied... (More)
This work presents a method to optimize multi-product chromatographic systems with multiple objective functions. The system studied is a neodymium, samarium, europium, gadolinium mixture separated in an ion exchange chromatography step. A homogeneous Langmuir Mobile Phase Modified model is calibrated to fit the experiments, and then used to perform the optimization task. For the optimization a multi-objective Differential Evolution algorithm was used, with weighting based on relative value of the components to find optimal operation points along the Pareto front. The objectives of the Pareto front are weighted productivity and weighted yield with purity as an equality constraint. A prioritizing scheme based on relative values is applied for determining the pooling order. A simple rule of thumb for pooling strategy selection is presented. The multi-objective optimization gives a Pareto front which shows the rule of thumb, as a gap in one of the objective functions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Chromatography A
volume
1218
issue
51
pages
9155 - 9161
publisher
Elsevier
external identifiers
  • wos:000298530000006
  • pmid:22079482
  • scopus:82555196722
ISSN
0021-9673
DOI
10.1016/j.chroma.2011.10.062
language
English
LU publication?
yes
id
5f06162d-3e75-42ef-9042-a7661b6a032b (old id 2220807)
date added to LUP
2011-12-13 16:22:40
date last changed
2017-07-09 04:04:13
@article{5f06162d-3e75-42ef-9042-a7661b6a032b,
  abstract     = {This work presents a method to optimize multi-product chromatographic systems with multiple objective functions. The system studied is a neodymium, samarium, europium, gadolinium mixture separated in an ion exchange chromatography step. A homogeneous Langmuir Mobile Phase Modified model is calibrated to fit the experiments, and then used to perform the optimization task. For the optimization a multi-objective Differential Evolution algorithm was used, with weighting based on relative value of the components to find optimal operation points along the Pareto front. The objectives of the Pareto front are weighted productivity and weighted yield with purity as an equality constraint. A prioritizing scheme based on relative values is applied for determining the pooling order. A simple rule of thumb for pooling strategy selection is presented. The multi-objective optimization gives a Pareto front which shows the rule of thumb, as a gap in one of the objective functions.},
  author       = {Max-Hansen, Mark and Ojala, Frida and Kifle, Dejene and Borg, Niklas and Nilsson, Bernt},
  issn         = {0021-9673},
  language     = {eng},
  number       = {51},
  pages        = {9155--9161},
  publisher    = {Elsevier},
  series       = {Journal of Chromatography A},
  title        = {Optimization of preparative chromatographic separation of multiple rare earth elements.},
  url          = {http://dx.doi.org/10.1016/j.chroma.2011.10.062},
  volume       = {1218},
  year         = {2011},
}