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How vitamin A metabolizing dendritic cells are generated in the gut mucosa.

Agace, William LU and Persson, Emma LU (2012) In Trends in Immunology 33. p.42-48
Abstract
CD103(+) dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103(+) DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and α4β7 on responding T and B cells, and enhance forkhead box P3(+) T regulatory and IgA plasma cell differentiation in vitro. In this review, we discuss the environmental signals that appear to promote vitamin A metabolising activity in SI CD103(+) DCs in the steady state and thus which may contribute to driving... (More)
CD103(+) dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103(+) DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and α4β7 on responding T and B cells, and enhance forkhead box P3(+) T regulatory and IgA plasma cell differentiation in vitro. In this review, we discuss the environmental signals that appear to promote vitamin A metabolising activity in SI CD103(+) DCs in the steady state and thus which may contribute to driving the unique nature of SI immune responses. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Immunology
volume
33
pages
42 - 48
publisher
Elsevier
external identifiers
  • wos:000299713800006
  • pmid:22079120
  • scopus:84855337070
ISSN
1471-4981
DOI
10.1016/j.it.2011.10.001
language
English
LU publication?
yes
id
17e4832c-7454-4049-8012-e611f8d0f7a0 (old id 2220837)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22079120?dopt=Abstract
date added to LUP
2011-12-02 21:14:01
date last changed
2017-08-13 04:35:15
@article{17e4832c-7454-4049-8012-e611f8d0f7a0,
  abstract     = {CD103(+) dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103(+) DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and α4β7 on responding T and B cells, and enhance forkhead box P3(+) T regulatory and IgA plasma cell differentiation in vitro. In this review, we discuss the environmental signals that appear to promote vitamin A metabolising activity in SI CD103(+) DCs in the steady state and thus which may contribute to driving the unique nature of SI immune responses.},
  author       = {Agace, William and Persson, Emma},
  issn         = {1471-4981},
  language     = {eng},
  pages        = {42--48},
  publisher    = {Elsevier},
  series       = {Trends in Immunology},
  title        = {How vitamin A metabolizing dendritic cells are generated in the gut mucosa.},
  url          = {http://dx.doi.org/10.1016/j.it.2011.10.001},
  volume       = {33},
  year         = {2012},
}