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Coagulation and inflammation-close allies in health and disease.

Dahlbäck, Björn LU (2012) In Seminars in Immunopathology 34. p.1-3
Abstract
The integrity of our bodies is under constant threat by external forces. Blood coagulation and inflammatory pathways are important, highly efficient defence systems that support health and well-being in both normal and challenged conditions. Being potentially dangerous for the own organism, they are kept under strict control by anticoagulant and anti-inflammatory mechanisms. Coagulation and inflammatory pathways are closely integrated by extensive crosstalk and tend to function in concert. They comprise a large number of cellular and molecular actors, which interact in extremely complex manners. A basic principle governing these interactions is the mutual activation of the pathways. Thus, the activation of coagulation leads to concomitant... (More)
The integrity of our bodies is under constant threat by external forces. Blood coagulation and inflammatory pathways are important, highly efficient defence systems that support health and well-being in both normal and challenged conditions. Being potentially dangerous for the own organism, they are kept under strict control by anticoagulant and anti-inflammatory mechanisms. Coagulation and inflammatory pathways are closely integrated by extensive crosstalk and tend to function in concert. They comprise a large number of cellular and molecular actors, which interact in extremely complex manners. A basic principle governing these interactions is the mutual activation of the pathways. Thus, the activation of coagulation leads to concomitant activation of inflammatory pathways, mirrored by the initiation of coagulation by inflammatory pathways. Efficient anticoagulant systems not only keep coagulation reactions under strict control but also exert control on inflammatory reactions. During inflammation, these anticoagulant/anti-inflammatory systems are repressed allowing full activation of coagulation and inflammation. Dysregulation of the delicate balance between these systems contributes to the pathogenesis of many diseases. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Immunopathology
volume
34
pages
1 - 3
publisher
Springer
external identifiers
  • wos:000297845200001
  • pmid:22051939
  • scopus:84859731632
ISSN
1863-2300
DOI
10.1007/s00281-011-0298-0
language
English
LU publication?
yes
id
b64a3c8f-217a-4d22-b56a-5cacaee1cd6f (old id 2221176)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22051939?dopt=Abstract
date added to LUP
2011-12-02 19:00:12
date last changed
2017-11-12 04:06:20
@article{b64a3c8f-217a-4d22-b56a-5cacaee1cd6f,
  abstract     = {The integrity of our bodies is under constant threat by external forces. Blood coagulation and inflammatory pathways are important, highly efficient defence systems that support health and well-being in both normal and challenged conditions. Being potentially dangerous for the own organism, they are kept under strict control by anticoagulant and anti-inflammatory mechanisms. Coagulation and inflammatory pathways are closely integrated by extensive crosstalk and tend to function in concert. They comprise a large number of cellular and molecular actors, which interact in extremely complex manners. A basic principle governing these interactions is the mutual activation of the pathways. Thus, the activation of coagulation leads to concomitant activation of inflammatory pathways, mirrored by the initiation of coagulation by inflammatory pathways. Efficient anticoagulant systems not only keep coagulation reactions under strict control but also exert control on inflammatory reactions. During inflammation, these anticoagulant/anti-inflammatory systems are repressed allowing full activation of coagulation and inflammation. Dysregulation of the delicate balance between these systems contributes to the pathogenesis of many diseases.},
  author       = {Dahlbäck, Björn},
  issn         = {1863-2300},
  language     = {eng},
  pages        = {1--3},
  publisher    = {Springer},
  series       = {Seminars in Immunopathology},
  title        = {Coagulation and inflammation-close allies in health and disease.},
  url          = {http://dx.doi.org/10.1007/s00281-011-0298-0},
  volume       = {34},
  year         = {2012},
}