Evaluation of the relationship between capillary and venous plasma glucose concentrations obtained by the HemoCue Glucose 201+ system during an oral glucose tolerance test
Ignell, Claes LU
and Berntorp, Kerstin
LU
(2011)
In Scandinavian Journal of Clinical & Laboratory Investigation
71(8).
p.670-675
- Abstract
- Abstract In 55 women with previous gestational diabetes mellitus, simultaneous capillary and venous plasma glucose concentrations were measured at 0, 30 and 120 min during a 75 g oral glucose tolerance test (OGTT). The aims of the study were to examine the relationship between capillary and venous glucose measurements, and to establish equations for the conversion of capillary and venous glucose concentrations using the HemoCue Glucose 201+ system. Additionally, the correlation between the capillary and venous glucose concentrations with the diagnostic cut-off limits proposed by the World Health Organization (WHO) in 1999 was evaluated. Capillary glucose concentrations were consistently higher than venous glucose concentrations at all time... (More)
- Abstract In 55 women with previous gestational diabetes mellitus, simultaneous capillary and venous plasma glucose concentrations were measured at 0, 30 and 120 min during a 75 g oral glucose tolerance test (OGTT). The aims of the study were to examine the relationship between capillary and venous glucose measurements, and to establish equations for the conversion of capillary and venous glucose concentrations using the HemoCue Glucose 201+ system. Additionally, the correlation between the capillary and venous glucose concentrations with the diagnostic cut-off limits proposed by the World Health Organization (WHO) in 1999 was evaluated. Capillary glucose concentrations were consistently higher than venous glucose concentrations at all time points of the OGTT (p < 0.001), and the correlations between the measurements were statistically highly significant (p < 0.001). The differences between the samples were greatest in the non-fasting state as revealed by the 95% prediction intervals (mmol/L) in Bland-Altman plots; ? 0.54 at 0 min, ? 2.01 at 30 min, and ? 1.35 at 120 min. Equivalence values for capillary plasma glucose concentrations derived from this study tended to be higher than those proposed by the WHO as diagnostic cut-off limits. Stratifying subjects by glucose tolerance status according to the WHO criteria revealed disagreements related to glucose values close to the diagnostic cut-off points. The study findings highlight the uncertainty associated with derived equivalence values. However, capillary plasma glucose measurements could be suitable for diagnostic purposes in epidemiological studies and when translating results on a group basis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2224635
- author
- Ignell, Claes
LU
and Berntorp, Kerstin
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- correlation, conversion algorithm, comparison method, Agreement, Bland-Altman plot
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 71
- issue
- 8
- pages
- 670 - 675
- publisher
- Informa Healthcare
- external identifiers
-
- wos:000296980600009
- scopus:81255143209
- pmid:21961814
- ISSN
- 1502-7686
- DOI
- 10.3109/00365513.2011.619703
- language
- English
- LU publication?
- yes
- additional info
- 8
- id
- a84e0500-185b-4000-a469-1fa1238c9066 (old id 2224635)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21961814
- date added to LUP
- 2016-04-01 10:25:04
- date last changed
- 2025-04-04 14:20:38
@article{a84e0500-185b-4000-a469-1fa1238c9066,
abstract = {{Abstract In 55 women with previous gestational diabetes mellitus, simultaneous capillary and venous plasma glucose concentrations were measured at 0, 30 and 120 min during a 75 g oral glucose tolerance test (OGTT). The aims of the study were to examine the relationship between capillary and venous glucose measurements, and to establish equations for the conversion of capillary and venous glucose concentrations using the HemoCue Glucose 201+ system. Additionally, the correlation between the capillary and venous glucose concentrations with the diagnostic cut-off limits proposed by the World Health Organization (WHO) in 1999 was evaluated. Capillary glucose concentrations were consistently higher than venous glucose concentrations at all time points of the OGTT (p < 0.001), and the correlations between the measurements were statistically highly significant (p < 0.001). The differences between the samples were greatest in the non-fasting state as revealed by the 95% prediction intervals (mmol/L) in Bland-Altman plots; ? 0.54 at 0 min, ? 2.01 at 30 min, and ? 1.35 at 120 min. Equivalence values for capillary plasma glucose concentrations derived from this study tended to be higher than those proposed by the WHO as diagnostic cut-off limits. Stratifying subjects by glucose tolerance status according to the WHO criteria revealed disagreements related to glucose values close to the diagnostic cut-off points. The study findings highlight the uncertainty associated with derived equivalence values. However, capillary plasma glucose measurements could be suitable for diagnostic purposes in epidemiological studies and when translating results on a group basis.}},
author = {{Ignell, Claes and Berntorp, Kerstin}},
issn = {{1502-7686}},
keywords = {{correlation; conversion algorithm; comparison method; Agreement; Bland-Altman plot}},
language = {{eng}},
number = {{8}},
pages = {{670--675}},
publisher = {{Informa Healthcare}},
series = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
title = {{Evaluation of the relationship between capillary and venous plasma glucose concentrations obtained by the HemoCue Glucose 201+ system during an oral glucose tolerance test}},
url = {{https://lup.lub.lu.se/search/files/1826991/2371000.pdf}},
doi = {{10.3109/00365513.2011.619703}},
volume = {{71}},
year = {{2011}},
}