Advanced

Gatekeeper pathways and cellular background in the pathogenesis and therapy of AML

Cammenga, Jörg LU (2005) In Leukemia 19(10). p.1719-1728
Abstract
Acute myelogenous leukemia (AML) is characterized by the accumulation of immature cells due to disturbed differentiation and proliferation of the myeloid lineage. Genetic alterations affecting transcription factors and receptor tyrosine kinases have been identified in AML and causally linked to the disease. The goal of this review is to address the role of the different genetic alterations in self-renewal and proliferation and to discuss the cellular background in which these events occur during the pathogenesis of AML. Data from AML samples, clinical studies and mouse models for AML will be used to support the different theories regarding the leukemogenesis of AML. Finally, this review wants to highlight the implication of these findings... (More)
Acute myelogenous leukemia (AML) is characterized by the accumulation of immature cells due to disturbed differentiation and proliferation of the myeloid lineage. Genetic alterations affecting transcription factors and receptor tyrosine kinases have been identified in AML and causally linked to the disease. The goal of this review is to address the role of the different genetic alterations in self-renewal and proliferation and to discuss the cellular background in which these events occur during the pathogenesis of AML. Data from AML samples, clinical studies and mouse models for AML will be used to support the different theories regarding the leukemogenesis of AML. Finally, this review wants to highlight the implication of these findings for the therapy of AML. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hematopoietic, therapy, transcription factors, AML, gatekeepers, stem/progenitor cells
in
Leukemia
volume
19
issue
10
pages
1719 - 1728
publisher
Nature Publishing Group
external identifiers
  • pmid:16107893
  • wos:000232204000002
  • scopus:27144523745
ISSN
1476-5551
DOI
10.1038/sj.leu.2403894
language
English
LU publication?
yes
id
c3d10141-7a91-4122-9bbe-2f5354d87eae (old id 223071)
date added to LUP
2007-08-14 08:53:23
date last changed
2017-01-01 06:41:54
@article{c3d10141-7a91-4122-9bbe-2f5354d87eae,
  abstract     = {Acute myelogenous leukemia (AML) is characterized by the accumulation of immature cells due to disturbed differentiation and proliferation of the myeloid lineage. Genetic alterations affecting transcription factors and receptor tyrosine kinases have been identified in AML and causally linked to the disease. The goal of this review is to address the role of the different genetic alterations in self-renewal and proliferation and to discuss the cellular background in which these events occur during the pathogenesis of AML. Data from AML samples, clinical studies and mouse models for AML will be used to support the different theories regarding the leukemogenesis of AML. Finally, this review wants to highlight the implication of these findings for the therapy of AML.},
  author       = {Cammenga, Jörg},
  issn         = {1476-5551},
  keyword      = {hematopoietic,therapy,transcription factors,AML,gatekeepers,stem/progenitor cells},
  language     = {eng},
  number       = {10},
  pages        = {1719--1728},
  publisher    = {Nature Publishing Group},
  series       = {Leukemia},
  title        = {Gatekeeper pathways and cellular background in the pathogenesis and therapy of AML},
  url          = {http://dx.doi.org/10.1038/sj.leu.2403894},
  volume       = {19},
  year         = {2005},
}