Gatekeeper pathways and cellular background in the pathogenesis and therapy of AML
(2005) In Leukemia 19(10). p.1719-1728- Abstract
- Acute myelogenous leukemia (AML) is characterized by the accumulation of immature cells due to disturbed differentiation and proliferation of the myeloid lineage. Genetic alterations affecting transcription factors and receptor tyrosine kinases have been identified in AML and causally linked to the disease. The goal of this review is to address the role of the different genetic alterations in self-renewal and proliferation and to discuss the cellular background in which these events occur during the pathogenesis of AML. Data from AML samples, clinical studies and mouse models for AML will be used to support the different theories regarding the leukemogenesis of AML. Finally, this review wants to highlight the implication of these findings... (More)
- Acute myelogenous leukemia (AML) is characterized by the accumulation of immature cells due to disturbed differentiation and proliferation of the myeloid lineage. Genetic alterations affecting transcription factors and receptor tyrosine kinases have been identified in AML and causally linked to the disease. The goal of this review is to address the role of the different genetic alterations in self-renewal and proliferation and to discuss the cellular background in which these events occur during the pathogenesis of AML. Data from AML samples, clinical studies and mouse models for AML will be used to support the different theories regarding the leukemogenesis of AML. Finally, this review wants to highlight the implication of these findings for the therapy of AML. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/223071
- author
- Cammenga, Jörg LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hematopoietic, therapy, transcription factors, AML, gatekeepers, stem/progenitor cells
- in
- Leukemia
- volume
- 19
- issue
- 10
- pages
- 1719 - 1728
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:16107893
- wos:000232204000002
- scopus:27144523745
- ISSN
- 1476-5551
- DOI
- 10.1038/sj.leu.2403894
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematology/Transplantation (013022014)
- id
- c3d10141-7a91-4122-9bbe-2f5354d87eae (old id 223071)
- date added to LUP
- 2016-04-01 15:33:09
- date last changed
- 2022-08-07 18:18:08
@article{c3d10141-7a91-4122-9bbe-2f5354d87eae,
abstract = {{Acute myelogenous leukemia (AML) is characterized by the accumulation of immature cells due to disturbed differentiation and proliferation of the myeloid lineage. Genetic alterations affecting transcription factors and receptor tyrosine kinases have been identified in AML and causally linked to the disease. The goal of this review is to address the role of the different genetic alterations in self-renewal and proliferation and to discuss the cellular background in which these events occur during the pathogenesis of AML. Data from AML samples, clinical studies and mouse models for AML will be used to support the different theories regarding the leukemogenesis of AML. Finally, this review wants to highlight the implication of these findings for the therapy of AML.}},
author = {{Cammenga, Jörg}},
issn = {{1476-5551}},
keywords = {{hematopoietic; therapy; transcription factors; AML; gatekeepers; stem/progenitor cells}},
language = {{eng}},
number = {{10}},
pages = {{1719--1728}},
publisher = {{Nature Publishing Group}},
series = {{Leukemia}},
title = {{Gatekeeper pathways and cellular background in the pathogenesis and therapy of AML}},
url = {{http://dx.doi.org/10.1038/sj.leu.2403894}},
doi = {{10.1038/sj.leu.2403894}},
volume = {{19}},
year = {{2005}},
}