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Osteolytic potential of triphenyl bismuth as an alternative contrast medium in acrylic bone cement

Xu, H; Abdulghani, Saba LU ; Behiri, J and Sabokbar, A (2005) In Journal of Biomedical Materials Research. Part B - Applied Biomaterials 75B(1). p.64-73
Abstract
Radiopaque cement containing barium sulfate causes significantly more bone resorption in vivo and in vitro than radiolucent cement. The aim of this study was to investigate the osteolytic potential of an alternative radiopaque agent, triphenyl bismuth (TPB). Bone cement particles containing various concentration of TPB (15 and 25 wt%) prepared by two methods, blending and dissolution, were added to monocytes in a bone resorption assay and the extent of lacunar resorption on dentine slices was determined. The results clearly show that cement particles containing TPB cause less bone resorption than cement particles containing barium sulfate. In addition, our results suggest that TPB prepared by dissolution in bone cement induces less... (More)
Radiopaque cement containing barium sulfate causes significantly more bone resorption in vivo and in vitro than radiolucent cement. The aim of this study was to investigate the osteolytic potential of an alternative radiopaque agent, triphenyl bismuth (TPB). Bone cement particles containing various concentration of TPB (15 and 25 wt%) prepared by two methods, blending and dissolution, were added to monocytes in a bone resorption assay and the extent of lacunar resorption on dentine slices was determined. The results clearly show that cement particles containing TPB cause less bone resorption than cement particles containing barium sulfate. In addition, our results suggest that TPB prepared by dissolution in bone cement induces less osteolytic response than TPB-cement prepared by blending. The osteolysis in response to bone cement wear particles may therefore be reduced with TPB prepared using the blending technique. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
triphenyl bismuth, radiopacity, bone cement, bone resorption, osteoclast
in
Journal of Biomedical Materials Research. Part B - Applied Biomaterials
volume
75B
issue
1
pages
64 - 73
publisher
John Wiley & Sons
external identifiers
  • pmid:16015616
  • wos:000232168200009
  • scopus:25844459980
ISSN
1552-4981
DOI
10.1002/jbm.b.30277
language
English
LU publication?
yes
id
17d91963-37ff-47c7-9130-b4346368d576 (old id 223113)
date added to LUP
2007-08-21 10:10:05
date last changed
2017-01-01 04:22:29
@article{17d91963-37ff-47c7-9130-b4346368d576,
  abstract     = {Radiopaque cement containing barium sulfate causes significantly more bone resorption in vivo and in vitro than radiolucent cement. The aim of this study was to investigate the osteolytic potential of an alternative radiopaque agent, triphenyl bismuth (TPB). Bone cement particles containing various concentration of TPB (15 and 25 wt%) prepared by two methods, blending and dissolution, were added to monocytes in a bone resorption assay and the extent of lacunar resorption on dentine slices was determined. The results clearly show that cement particles containing TPB cause less bone resorption than cement particles containing barium sulfate. In addition, our results suggest that TPB prepared by dissolution in bone cement induces less osteolytic response than TPB-cement prepared by blending. The osteolysis in response to bone cement wear particles may therefore be reduced with TPB prepared using the blending technique.},
  author       = {Xu, H and Abdulghani, Saba and Behiri, J and Sabokbar, A},
  issn         = {1552-4981},
  keyword      = {triphenyl bismuth,radiopacity,bone cement,bone resorption,osteoclast},
  language     = {eng},
  number       = {1},
  pages        = {64--73},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Biomedical Materials Research. Part B - Applied Biomaterials},
  title        = {Osteolytic potential of triphenyl bismuth as an alternative contrast medium in acrylic bone cement},
  url          = {http://dx.doi.org/10.1002/jbm.b.30277},
  volume       = {75B},
  year         = {2005},
}