Resting-state hippocampal asymmetry as a marker for memory and olfactory deficit in parkinson’s disease
Eek, Tom ; Bolton, Thomas A.W. ; Dizdar, Nil ; Larsson, Maria ; Lundin, Fredrik and Georgiopoulos, Charalampos LU
(2025)
In Scientific Reports
15(1).
- Abstract
Memory decline is a central cognitive symptom in Parkinson’s Disease (PD). While task-fMRI studies link hippocampal activity (AHA) to poorer memory and olfactory performance, this relationship during rest remains understudied. The objectives of this study are to examine differences in resting-state hippocampal networks, explore the occurrence of reduced AHA within these networks, and investigate its impact on memory and olfaction in PD. Thirty-nine PD patients awaiting evaluation for device-aided Parkinson therapy and 46 healthy controls (HC) underwent resting-state fMRI (rs-fMRI). PD patients also completed a memory and olfactory assessment. Co-activation pattern (CAP) analysis was performed on the rs-fMRI data. Our results... (More)
Memory decline is a central cognitive symptom in Parkinson’s Disease (PD). While task-fMRI studies link hippocampal activity (AHA) to poorer memory and olfactory performance, this relationship during rest remains understudied. The objectives of this study are to examine differences in resting-state hippocampal networks, explore the occurrence of reduced AHA within these networks, and investigate its impact on memory and olfaction in PD. Thirty-nine PD patients awaiting evaluation for device-aided Parkinson therapy and 46 healthy controls (HC) underwent resting-state fMRI (rs-fMRI). PD patients also completed a memory and olfactory assessment. Co-activation pattern (CAP) analysis was performed on the rs-fMRI data. Our results demonstrated reduced activity in two hippocampal networks in PD: Network 1, incorporating the visual cortex, cerebellum, superior parietal lobule, and precuneus, and Network 5, incorporating parts of the central executive network. PD subgroups with reduced AHA in Network 1 and 5 performed significantly worse on tests of auditory-verbal short-term, long-term and recognition memory, as well as odor identification. In conclusion, within specific resting-state hippocampal networks, reduced AHA in PD is linked to poorer auditory-verbal memory and odor identification.
(Less)
- author
- Eek, Tom
; Bolton, Thomas A.W.
; Dizdar, Nil
; Larsson, Maria
; Lundin, Fredrik
and Georgiopoulos, Charalampos
LU
- organization
- publishing date
- 2025-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Asymmetric hippocampal activity, Co-activation pattern analysis, Memory, Odor identification, Parkinson’s disease
- in
- Scientific Reports
- volume
- 15
- issue
- 1
- article number
- 42022
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:41298806
- scopus:105023213127
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-025-29976-2
- language
- English
- LU publication?
- yes
- id
- 223cb8cb-8cdd-4714-9e43-b9f9c2157681
- date added to LUP
- 2026-01-14 13:21:13
- date last changed
- 2026-01-28 14:43:20
@article{223cb8cb-8cdd-4714-9e43-b9f9c2157681,
abstract = {{<p>Memory decline is a central cognitive symptom in Parkinson’s Disease (PD). While task-fMRI studies link hippocampal activity (AHA) to poorer memory and olfactory performance, this relationship during rest remains understudied. The objectives of this study are to examine differences in resting-state hippocampal networks, explore the occurrence of reduced AHA within these networks, and investigate its impact on memory and olfaction in PD. Thirty-nine PD patients awaiting evaluation for device-aided Parkinson therapy and 46 healthy controls (HC) underwent resting-state fMRI (rs-fMRI). PD patients also completed a memory and olfactory assessment. Co-activation pattern (CAP) analysis was performed on the rs-fMRI data. Our results demonstrated reduced activity in two hippocampal networks in PD: Network 1, incorporating the visual cortex, cerebellum, superior parietal lobule, and precuneus, and Network 5, incorporating parts of the central executive network. PD subgroups with reduced AHA in Network 1 and 5 performed significantly worse on tests of auditory-verbal short-term, long-term and recognition memory, as well as odor identification. In conclusion, within specific resting-state hippocampal networks, reduced AHA in PD is linked to poorer auditory-verbal memory and odor identification.</p>}},
author = {{Eek, Tom and Bolton, Thomas A.W. and Dizdar, Nil and Larsson, Maria and Lundin, Fredrik and Georgiopoulos, Charalampos}},
issn = {{2045-2322}},
keywords = {{Asymmetric hippocampal activity; Co-activation pattern analysis; Memory; Odor identification; Parkinson’s disease}},
language = {{eng}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Scientific Reports}},
title = {{Resting-state hippocampal asymmetry as a marker for memory and olfactory deficit in parkinson’s disease}},
url = {{http://dx.doi.org/10.1038/s41598-025-29976-2}},
doi = {{10.1038/s41598-025-29976-2}},
volume = {{15}},
year = {{2025}},
}