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Identification of Phenotypes With Different Clinical Outcomes in Knee Osteoarthritis: Data From the Osteoarthritis Initiative

Knoop, Jesper; van der Leeden, Marike; Thorstensson, Carina LU ; Roorda, Leo D.; Lems, Willem F.; Knol, Dirk L.; Steultjens, Martijn P. M. and Dekker, Joost (2011) In Arthritis Care and Research1988-01-01+01:002000-01-01+01:00 63(11). p.1535-1542
Abstract
Objective. To identify subgroups or phenotypes of knee osteoarthritis (OA) patients based on similarities of clinically relevant patient characteristics, and to compare clinical outcomes of these phenotypes. Methods. Data from 842 knee OA patients of the Osteoarthritis Initiative were used. A cluster analysis method was performed, in which clusters were formed based on similarities in 4 clinically relevant, easily available variables: severity of radiographic OA, lower extremity muscle strength, body mass index, and depression. Univariable and multivariable regression analyses were used to compare phenotypes on clinical outcomes (pain and activity limitations), taking into account possible confounders. Results. Five phenotypes of knee OA... (More)
Objective. To identify subgroups or phenotypes of knee osteoarthritis (OA) patients based on similarities of clinically relevant patient characteristics, and to compare clinical outcomes of these phenotypes. Methods. Data from 842 knee OA patients of the Osteoarthritis Initiative were used. A cluster analysis method was performed, in which clusters were formed based on similarities in 4 clinically relevant, easily available variables: severity of radiographic OA, lower extremity muscle strength, body mass index, and depression. Univariable and multivariable regression analyses were used to compare phenotypes on clinical outcomes (pain and activity limitations), taking into account possible confounders. Results. Five phenotypes of knee OA patients were identified: "minimal joint disease phenotype," "strong muscle phenotype," "nonobese and weak muscle phenotype," "obese and weak muscle phenotype," and "depressive phenotype." The "depressive phenotype" and "obese and weak muscle phenotype" showed higher pain levels and more severe activity limitations than the other 3 phenotypes. Conclusion. Five phenotypes based on clinically relevant patient characteristics can be identified in the heterogeneous population of knee OA patients. These phenotypes showed different clinical outcomes. Interventions may need to be tailored to these clinical phenotypes. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Arthritis Care and Research1988-01-01+01:002000-01-01+01:00
volume
63
issue
11
pages
1535 - 1542
publisher
John Wiley & Sons
external identifiers
  • wos:000297217900007
  • scopus:80055099774
ISSN
2151-4658
DOI
10.1002/acr.20571
language
English
LU publication?
yes
id
48fab457-ad87-4c4d-9e04-483c6fc4a94a (old id 2243197)
date added to LUP
2012-01-02 07:55:48
date last changed
2017-11-19 03:07:40
@article{48fab457-ad87-4c4d-9e04-483c6fc4a94a,
  abstract     = {Objective. To identify subgroups or phenotypes of knee osteoarthritis (OA) patients based on similarities of clinically relevant patient characteristics, and to compare clinical outcomes of these phenotypes. Methods. Data from 842 knee OA patients of the Osteoarthritis Initiative were used. A cluster analysis method was performed, in which clusters were formed based on similarities in 4 clinically relevant, easily available variables: severity of radiographic OA, lower extremity muscle strength, body mass index, and depression. Univariable and multivariable regression analyses were used to compare phenotypes on clinical outcomes (pain and activity limitations), taking into account possible confounders. Results. Five phenotypes of knee OA patients were identified: "minimal joint disease phenotype," "strong muscle phenotype," "nonobese and weak muscle phenotype," "obese and weak muscle phenotype," and "depressive phenotype." The "depressive phenotype" and "obese and weak muscle phenotype" showed higher pain levels and more severe activity limitations than the other 3 phenotypes. Conclusion. Five phenotypes based on clinically relevant patient characteristics can be identified in the heterogeneous population of knee OA patients. These phenotypes showed different clinical outcomes. Interventions may need to be tailored to these clinical phenotypes.},
  author       = {Knoop, Jesper and van der Leeden, Marike and Thorstensson, Carina and Roorda, Leo D. and Lems, Willem F. and Knol, Dirk L. and Steultjens, Martijn P. M. and Dekker, Joost},
  issn         = {2151-4658},
  language     = {eng},
  number       = {11},
  pages        = {1535--1542},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis Care and Research1988-01-01+01:002000-01-01+01:00},
  title        = {Identification of Phenotypes With Different Clinical Outcomes in Knee Osteoarthritis: Data From the Osteoarthritis Initiative},
  url          = {http://dx.doi.org/10.1002/acr.20571},
  volume       = {63},
  year         = {2011},
}