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Lactase persistence and ovarian carcinoma risk in Finland, Poland and Sweden

Kuokkanen, M; Butzow, R; Rasinpera, H; Medrek, K; Nilbert, Mef LU ; Malander, Susanne LU ; Lubinski, J and Jarvela, I (2005) In International Journal of Cancer 117(1). p.90-94
Abstract
Ovarian carcinoma is the fourth most common cause of cancer death in women. The cause and pathogenesis of this disease has remained obscure. Galactose, the hydrolyzing product of the milk sugar lactose, has been hypothesized to be toxic to ovarian epithelial cells and consumption of dairy products and lactase persistence has been suggested to be a risk factor for ovarian carcinoma. In adults, downregulation of lactase depends on a variant C/T-13910 at the 5' end of the lactase gene. To explore whether lactase persistence is related to the risk of ovarian carcinoma we determined the C/T-13910 genotype in a cohort of 782 women with ovarian carcinoma. The C/T-13910 genotype was defined by solid phase minisequencing from 327 Finnish, 303... (More)
Ovarian carcinoma is the fourth most common cause of cancer death in women. The cause and pathogenesis of this disease has remained obscure. Galactose, the hydrolyzing product of the milk sugar lactose, has been hypothesized to be toxic to ovarian epithelial cells and consumption of dairy products and lactase persistence has been suggested to be a risk factor for ovarian carcinoma. In adults, downregulation of lactase depends on a variant C/T-13910 at the 5' end of the lactase gene. To explore whether lactase persistence is related to the risk of ovarian carcinoma we determined the C/T-13910 genotype in a cohort of 782 women with ovarian carcinoma. The C/T-13910 genotype was defined by solid phase minisequencing from 327 Finnish, 303 Polish, 152 Swedish patients and 938 Finnish, 296 Polish and 97 Swedish healthy individuals served as controls. Lactase persistence did not associate significantly with increased risk for ovarian carcinoma in the Finnish odds ratio (OR = 0.77, 95% confidence interval [CI] = 0.57-1.05, p = 0.097), in the Polish (OR = 0.95, 95% Cl = 0.68-1.33, p = 0.75), or in the Swedish populations (OR = 1.63, 95% Cl = 0.65-4.08, p = 0.29). Our results do not support the hypothesis that lactase persistence increases the ovarian carcinoma risk. On the contrary, lactase persistence may decrease the ovarian carcinoma risk at least in the Finnish population. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Finland, C/T-13910 polymorphism, lactase persistence, epithelial ovarian cancer, Poland, Sweden
in
International Journal of Cancer
volume
117
issue
1
pages
90 - 94
publisher
John Wiley & Sons
external identifiers
  • wos:000231638900011
  • pmid:15880573
  • scopus:24644436926
ISSN
0020-7136
DOI
10.1002/ijc.21130
language
English
LU publication?
yes
id
e7d09b1e-bcb5-4f24-813b-639579cbc586 (old id 224927)
date added to LUP
2007-08-16 14:09:28
date last changed
2017-10-08 03:34:31
@article{e7d09b1e-bcb5-4f24-813b-639579cbc586,
  abstract     = {Ovarian carcinoma is the fourth most common cause of cancer death in women. The cause and pathogenesis of this disease has remained obscure. Galactose, the hydrolyzing product of the milk sugar lactose, has been hypothesized to be toxic to ovarian epithelial cells and consumption of dairy products and lactase persistence has been suggested to be a risk factor for ovarian carcinoma. In adults, downregulation of lactase depends on a variant C/T-13910 at the 5' end of the lactase gene. To explore whether lactase persistence is related to the risk of ovarian carcinoma we determined the C/T-13910 genotype in a cohort of 782 women with ovarian carcinoma. The C/T-13910 genotype was defined by solid phase minisequencing from 327 Finnish, 303 Polish, 152 Swedish patients and 938 Finnish, 296 Polish and 97 Swedish healthy individuals served as controls. Lactase persistence did not associate significantly with increased risk for ovarian carcinoma in the Finnish odds ratio (OR = 0.77, 95% confidence interval [CI] = 0.57-1.05, p = 0.097), in the Polish (OR = 0.95, 95% Cl = 0.68-1.33, p = 0.75), or in the Swedish populations (OR = 1.63, 95% Cl = 0.65-4.08, p = 0.29). Our results do not support the hypothesis that lactase persistence increases the ovarian carcinoma risk. On the contrary, lactase persistence may decrease the ovarian carcinoma risk at least in the Finnish population.},
  author       = {Kuokkanen, M and Butzow, R and Rasinpera, H and Medrek, K and Nilbert, Mef and Malander, Susanne and Lubinski, J and Jarvela, I},
  issn         = {0020-7136},
  keyword      = {Finland,C/T-13910 polymorphism,lactase persistence,epithelial ovarian cancer,Poland,Sweden},
  language     = {eng},
  number       = {1},
  pages        = {90--94},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Lactase persistence and ovarian carcinoma risk in Finland, Poland and Sweden},
  url          = {http://dx.doi.org/10.1002/ijc.21130},
  volume       = {117},
  year         = {2005},
}