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Microwaves from GSM mobile telephones affect 53BP1 and gamma-H2AX foci in human lymphocytes from hypersensitive and healthy persons

Markova, E; Hillert, L; Malmgren, Lars LU ; Persson, Bertil R LU and Belyaev, IY (2005) In Environmental Health Perspectives 113(9). p.1172-1177
Abstract
The data on biologic effects of nonthermal microwaves (MWs) from mobile telephones are diverse, and these effects are presently ignored by safety standards of the International Commission for Non-Ionizing Radiation Protection (ICNIRP). In the present study, we investigated effects of MWs of Global System for Mobile Communication (GSM) at different carrier frequencies on human lymphocytes from healthy persons and from persons reporting hypersensitivity to electromagnetic fields (EMFs). We measured the changes in chromatin conformation, which are indicative of stress response and genotoxic effects, by the method of anomalous viscosity time dependence, and we analyzed tumor suppressor p53-binding protein 1 (53BP1) and phosphorylated histone... (More)
The data on biologic effects of nonthermal microwaves (MWs) from mobile telephones are diverse, and these effects are presently ignored by safety standards of the International Commission for Non-Ionizing Radiation Protection (ICNIRP). In the present study, we investigated effects of MWs of Global System for Mobile Communication (GSM) at different carrier frequencies on human lymphocytes from healthy persons and from persons reporting hypersensitivity to electromagnetic fields (EMFs). We measured the changes in chromatin conformation, which are indicative of stress response and genotoxic effects, by the method of anomalous viscosity time dependence, and we analyzed tumor suppressor p53-binding protein 1 (53BP1) and phosphorylated histone H2AX (gamma-H2AX), which have been shown to colocalize in distinct foci with DNA double-strand breaks (DSBs), using immunofluorescence confocal laser microscopy. We found that MWs from GSM mobile telephones affect chromatin conformation and 53BP1/gamma-H2AX foci similar to heat shock. For the first time, we report here that effects of MWs from mobile telephones on human lymphocytes are dependent on carrier frequency. On average, the same response was observed in lymphocytes from hypersensitive and healthy subjects. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
stress response, hypersensitivity to electromagnetic fields, DNA double-strand breaks, 53BP1 and gamma-H2AX foci, chromatin
in
Environmental Health Perspectives
volume
113
issue
9
pages
1172 - 1177
publisher
National Institute of Environmental Health Science
external identifiers
  • wos:000231677700035
  • pmid:16140623
  • scopus:25844432196
ISSN
1552-9924
DOI
10.1289/ehp.7561
language
English
LU publication?
yes
id
52fe5f1f-c83c-4bb4-b92d-e98688f969d0 (old id 224998)
date added to LUP
2007-08-20 08:31:31
date last changed
2017-08-13 04:17:40
@article{52fe5f1f-c83c-4bb4-b92d-e98688f969d0,
  abstract     = {The data on biologic effects of nonthermal microwaves (MWs) from mobile telephones are diverse, and these effects are presently ignored by safety standards of the International Commission for Non-Ionizing Radiation Protection (ICNIRP). In the present study, we investigated effects of MWs of Global System for Mobile Communication (GSM) at different carrier frequencies on human lymphocytes from healthy persons and from persons reporting hypersensitivity to electromagnetic fields (EMFs). We measured the changes in chromatin conformation, which are indicative of stress response and genotoxic effects, by the method of anomalous viscosity time dependence, and we analyzed tumor suppressor p53-binding protein 1 (53BP1) and phosphorylated histone H2AX (gamma-H2AX), which have been shown to colocalize in distinct foci with DNA double-strand breaks (DSBs), using immunofluorescence confocal laser microscopy. We found that MWs from GSM mobile telephones affect chromatin conformation and 53BP1/gamma-H2AX foci similar to heat shock. For the first time, we report here that effects of MWs from mobile telephones on human lymphocytes are dependent on carrier frequency. On average, the same response was observed in lymphocytes from hypersensitive and healthy subjects.},
  author       = {Markova, E and Hillert, L and Malmgren, Lars and Persson, Bertil R and Belyaev, IY},
  issn         = {1552-9924},
  keyword      = {stress response,hypersensitivity to electromagnetic fields,DNA double-strand breaks,53BP1 and gamma-H2AX foci,chromatin},
  language     = {eng},
  number       = {9},
  pages        = {1172--1177},
  publisher    = {National Institute of Environmental Health Science},
  series       = {Environmental Health Perspectives},
  title        = {Microwaves from GSM mobile telephones affect 53BP1 and gamma-H2AX foci in human lymphocytes from hypersensitive and healthy persons},
  url          = {http://dx.doi.org/10.1289/ehp.7561},
  volume       = {113},
  year         = {2005},
}