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DNA adducts and lung cancer risk: A prospective study

Peluso, M; Munnia, A; Hoek, G; Krzyzanowski, M; Veglia, F; Airoldi, L; Autrup, H; Dunning, A; Garte, S and Hainaut, P, et al. (2005) In Cancer Research 65(17). p.8042-8048
Abstract
Objectives were to investigate prospectively the ability of DNA adducts to predict cancer and to study the determinants of adducts, especially air pollutants. DNA adducts were measured in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC investigation. Cases included newly diagnosed lung cancer (n = 115), upper respiratory cancers (pharynx and larynx, n 82), bladder cancer (n = 124), leukemia (n = 166), and chronic obstructive pulmonary disease or emphysema deaths (n = 77) accrued after a median follow-up of 7 years among the EPIC former smokers and never-smokers. Three controls per case were matched for questionnaire analyses and two controls per case for laboratory analyses. Matching... (More)
Objectives were to investigate prospectively the ability of DNA adducts to predict cancer and to study the determinants of adducts, especially air pollutants. DNA adducts were measured in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC investigation. Cases included newly diagnosed lung cancer (n = 115), upper respiratory cancers (pharynx and larynx, n 82), bladder cancer (n = 124), leukemia (n = 166), and chronic obstructive pulmonary disease or emphysema deaths (n = 77) accrued after a median follow-up of 7 years among the EPIC former smokers and never-smokers. Three controls per case were matched for questionnaire analyses and two controls per case for laboratory analyses. Matching criteria were gender, age, smoking status, country of recruitment, and follow-up time. Individual exposure to air pollution was assessed using concentration data from monitoring stations in routine air quality monitoring networks. Leukocyte DNA adducts were analyzed blindly using (32)p postlabeling technique. Adducts were associated with the subsequent risk of lung cancer, with an odds ratio (OR) of 1.86 [95% confidence interval (95% CI), 0.88-3.931 when comparing detectable versus nondetectable adducts. The association with lung cancer was stronger in never-smokers (OR, 4.04; 95% CI, 1.06-15.42) and among the younger age groups. After exclusion of the cancers occurring in the first 36 months of follow-up, the OR was 4.16 (95% CI, 1.24-13.88). A positive association was found between DNA adducts and ozone (O-3) concentration. Our prospective study suggests that leukocyte DNA adducts may predict lung cancer risk of never-smokers. Besides, the association of DNA adduct levels with O-3 indicates a possible role for photochemical smog in determining DNA damage. (Less)
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Contribution to journal
publication status
published
subject
in
Cancer Research
volume
65
issue
17
pages
8042 - 8048
publisher
American Association for Cancer Research Inc.
external identifiers
  • wos:000231659500068
  • pmid:16140979
  • scopus:24744449556
ISSN
1538-7445
DOI
10.1158/0008-5472.CAN-04-3488
language
English
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yes
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29517132-9ff1-4396-9bdf-1ea628ad0938 (old id 225049)
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2007-08-09 16:46:24
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2017-08-20 04:26:50
@article{29517132-9ff1-4396-9bdf-1ea628ad0938,
  abstract     = {Objectives were to investigate prospectively the ability of DNA adducts to predict cancer and to study the determinants of adducts, especially air pollutants. DNA adducts were measured in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC investigation. Cases included newly diagnosed lung cancer (n = 115), upper respiratory cancers (pharynx and larynx, n 82), bladder cancer (n = 124), leukemia (n = 166), and chronic obstructive pulmonary disease or emphysema deaths (n = 77) accrued after a median follow-up of 7 years among the EPIC former smokers and never-smokers. Three controls per case were matched for questionnaire analyses and two controls per case for laboratory analyses. Matching criteria were gender, age, smoking status, country of recruitment, and follow-up time. Individual exposure to air pollution was assessed using concentration data from monitoring stations in routine air quality monitoring networks. Leukocyte DNA adducts were analyzed blindly using (32)p postlabeling technique. Adducts were associated with the subsequent risk of lung cancer, with an odds ratio (OR) of 1.86 [95% confidence interval (95% CI), 0.88-3.931 when comparing detectable versus nondetectable adducts. The association with lung cancer was stronger in never-smokers (OR, 4.04; 95% CI, 1.06-15.42) and among the younger age groups. After exclusion of the cancers occurring in the first 36 months of follow-up, the OR was 4.16 (95% CI, 1.24-13.88). A positive association was found between DNA adducts and ozone (O-3) concentration. Our prospective study suggests that leukocyte DNA adducts may predict lung cancer risk of never-smokers. Besides, the association of DNA adduct levels with O-3 indicates a possible role for photochemical smog in determining DNA damage.},
  author       = {Peluso, M and Munnia, A and Hoek, G and Krzyzanowski, M and Veglia, F and Airoldi, L and Autrup, H and Dunning, A and Garte, S and Hainaut, P and Malaveille, C and Gormally, E and Matullo, G and Overvad, K and Raaschou-Nielsen, O and Clavel-Chapelon, F and Linseisen, J and Boeing, H and Trichopoulou, A and Trichopoulos, D and Kaladidi, A and Palli, D and Krogh, V and Tumino, R and Panico, S and Bueno-De-Mesquita, H B and Peeters, P H and Kumle, M and Gonzalez, C A and Martinez, C and Dorronsoro, M and Barricarte, A and Navarro, C and Quiros, J R and Berglund, Göran and Janzon, Lars and Jarvholm, B and Day, N E and Key, TJ and Saracci, R and Kaaks, R and Riboli, E and Vineis, P},
  issn         = {1538-7445},
  language     = {eng},
  number       = {17},
  pages        = {8042--8048},
  publisher    = {American Association for Cancer Research Inc.},
  series       = {Cancer Research},
  title        = {DNA adducts and lung cancer risk: A prospective study},
  url          = {http://dx.doi.org/10.1158/0008-5472.CAN-04-3488},
  volume       = {65},
  year         = {2005},
}