A randomized multicenter study to compare two treatment regimens of topical methyl aminolevulinate (Metvix (R))-PDT in actinic keratosis of the face and scalp
(2005) In Acta Dermato-Venereologica 85(5). p.424-428- Abstract
- Photodynamic therapy (PDT) with topical methyl aminolevulinate ( MAL) administered in two treatment sessions separated by 1 week is an effective treatment for actinic keratoses. This open prospective study compared the efficacy and safety of MAL-PDT given as a single treatment with two treatments of MAL-PDT 1 week apart. Two hundred and eleven patients with 413 thin to moderately thick actinic keratoses were randomized to either a single treatment with PDT using topical MAL ( regimen I; n=105) or two treatments 1 week apart ( regimen II; n=106). Each treatment involved surface debridement, application of Metvix(R) cream (160 mg/g) for 3 h, followed by illumination with red light using a light-emitting diode system ( peak wavelength 634 +/-... (More)
- Photodynamic therapy (PDT) with topical methyl aminolevulinate ( MAL) administered in two treatment sessions separated by 1 week is an effective treatment for actinic keratoses. This open prospective study compared the efficacy and safety of MAL-PDT given as a single treatment with two treatments of MAL-PDT 1 week apart. Two hundred and eleven patients with 413 thin to moderately thick actinic keratoses were randomized to either a single treatment with PDT using topical MAL ( regimen I; n=105) or two treatments 1 week apart ( regimen II; n=106). Each treatment involved surface debridement, application of Metvix(R) cream (160 mg/g) for 3 h, followed by illumination with red light using a light-emitting diode system ( peak wavelength 634 +/- 3 nm, light dose 37 J/cm(2)). Thirty-seven lesions (19%) with a non-complete response 3 months after a single treatment were re-treated. All patients were followed up 3 months after the last treatment. A total of 400 lesions, 198 initially treated once and 202 treated twice, were evaluable. Complete response rate for thin lesions after a single treatment was 93% (95% CI = 87 - 97%), which was similar to 89% ( 82 - 96%) after repeated treatment. Response rates were lower after single treatment of thicker lesions (70% ( 60 - 78%) vs 84% ( 77 - 91%)), but improved after repeated treatment (88% ( 82 - 94%)). The conclusion of this study is that single treatment with topical MAL-PDT is effective for thin actinic keratosis lesions; however, repeated treatment is recommended for thicker or non-responding lesions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/225123
- author
- Tarstedt, M ; Rosdahl, I ; Berne, B ; Svanberg, Katarina LU and Wennberg, AM
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- methyl aminolevulinate, actinic keratosis, clinical trial, photodynamic therapy, topical
- in
- Acta Dermato-Venereologica
- volume
- 85
- issue
- 5
- pages
- 424 - 428
- publisher
- Medical Journals Limited
- external identifiers
-
- pmid:16159735
- wos:000231813200009
- scopus:25144511078
- pmid:16159735
- ISSN
- 1651-2057
- DOI
- 10.1080/00015550510032887
- language
- English
- LU publication?
- yes
- id
- 4f4949bd-88af-425f-9aea-928d535f4de4 (old id 225123)
- date added to LUP
- 2016-04-01 15:55:54
- date last changed
- 2022-02-05 03:59:10
@article{4f4949bd-88af-425f-9aea-928d535f4de4,
abstract = {{Photodynamic therapy (PDT) with topical methyl aminolevulinate ( MAL) administered in two treatment sessions separated by 1 week is an effective treatment for actinic keratoses. This open prospective study compared the efficacy and safety of MAL-PDT given as a single treatment with two treatments of MAL-PDT 1 week apart. Two hundred and eleven patients with 413 thin to moderately thick actinic keratoses were randomized to either a single treatment with PDT using topical MAL ( regimen I; n=105) or two treatments 1 week apart ( regimen II; n=106). Each treatment involved surface debridement, application of Metvix(R) cream (160 mg/g) for 3 h, followed by illumination with red light using a light-emitting diode system ( peak wavelength 634 +/- 3 nm, light dose 37 J/cm(2)). Thirty-seven lesions (19%) with a non-complete response 3 months after a single treatment were re-treated. All patients were followed up 3 months after the last treatment. A total of 400 lesions, 198 initially treated once and 202 treated twice, were evaluable. Complete response rate for thin lesions after a single treatment was 93% (95% CI = 87 - 97%), which was similar to 89% ( 82 - 96%) after repeated treatment. Response rates were lower after single treatment of thicker lesions (70% ( 60 - 78%) vs 84% ( 77 - 91%)), but improved after repeated treatment (88% ( 82 - 94%)). The conclusion of this study is that single treatment with topical MAL-PDT is effective for thin actinic keratosis lesions; however, repeated treatment is recommended for thicker or non-responding lesions.}},
author = {{Tarstedt, M and Rosdahl, I and Berne, B and Svanberg, Katarina and Wennberg, AM}},
issn = {{1651-2057}},
keywords = {{methyl aminolevulinate; actinic keratosis; clinical trial; photodynamic therapy; topical}},
language = {{eng}},
number = {{5}},
pages = {{424--428}},
publisher = {{Medical Journals Limited}},
series = {{Acta Dermato-Venereologica}},
title = {{A randomized multicenter study to compare two treatment regimens of topical methyl aminolevulinate (Metvix (R))-PDT in actinic keratosis of the face and scalp}},
url = {{http://dx.doi.org/10.1080/00015550510032887}},
doi = {{10.1080/00015550510032887}},
volume = {{85}},
year = {{2005}},
}