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Lower vitamin D levels are associated with depression among community-dwelling European men

Lee, David M.; Tajar, Abdelouahid; O'Neill, Terence W.; O'Connor, Daryl B.; Bartfai, Gyorgy; Boonen, Steven; Bouillon, Roger; Casanueva, Felipe F.; Finn, Joseph D. and Forte, Gianni, et al. (2011) In Journal of Psychopharmacology 25(10). p.1320-1328
Abstract
Low serum 25-hydroxyvitamin D (25(OH)D) and elevated parathyroid hormone (PTH) Levels have been linked with depressive symptoms among adults in various clinical settings. Data in generally healthy, community-dwelling individuals remain inconclusive. We investigated whether depression was associated with 25(OH)D and/or PTH in a sample of middle-aged and older men (n = 3369; mean age 60 +/- 11) participating in the European Male Ageing Study, and whether any associations were explained by lifestyle and health factors. The Beck Depression Inventory-II (BDI-II) was used to screen for depression, and serum 25(OH)D and PTH levels measured by radioimmunoassay. Univariate analysis revealed that 25(OH)D levels were lower (p < 0.001) and PTH... (More)
Low serum 25-hydroxyvitamin D (25(OH)D) and elevated parathyroid hormone (PTH) Levels have been linked with depressive symptoms among adults in various clinical settings. Data in generally healthy, community-dwelling individuals remain inconclusive. We investigated whether depression was associated with 25(OH)D and/or PTH in a sample of middle-aged and older men (n = 3369; mean age 60 +/- 11) participating in the European Male Ageing Study, and whether any associations were explained by lifestyle and health factors. The Beck Depression Inventory-II (BDI-II) was used to screen for depression, and serum 25(OH)D and PTH levels measured by radioimmunoassay. Univariate analysis revealed that 25(OH)D levels were lower (p < 0.001) and PTH higher (p = 0.004) in people with depression. In age- and centre-adjusted linear regressions a higher BDI-II score was significantly associated with tower levels of 25(OH)D (p = 0.004). After adjustment for lifestyle and health factors this relationship was attenuated but remained significant (p = 0.01). Using multivariable logistic regression the odds for depression increased approximately 70% across decreasing 25(OH)D quartiles (p(trend) = 0.04). There was no independent association between PIN and depression in any of the muttivariable regressions. Our results reveal an inverse association between 25(OH)D levels and depression, largely independent of several lifestyle and health factors. Further studies are required to determine whether higher levels of vitamin D have an antidepressant effect in older adults. (Less)
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Contribution to journal
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published
subject
keywords
Ageing, depression, male health, parathyroid hormone, population, survey, vitamin D
in
Journal of Psychopharmacology
volume
25
issue
10
pages
1320 - 1328
publisher
SAGE Publications Inc.
external identifiers
  • wos:000296892800007
  • scopus:82955214038
ISSN
1461-7285
DOI
10.1177/0269881110379287
language
English
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yes
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54ff1f71-1b22-445c-8214-bf2e3d7fb7f3 (old id 2253188)
date added to LUP
2012-01-02 07:59:24
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2017-09-17 03:53:58
@article{54ff1f71-1b22-445c-8214-bf2e3d7fb7f3,
  abstract     = {Low serum 25-hydroxyvitamin D (25(OH)D) and elevated parathyroid hormone (PTH) Levels have been linked with depressive symptoms among adults in various clinical settings. Data in generally healthy, community-dwelling individuals remain inconclusive. We investigated whether depression was associated with 25(OH)D and/or PTH in a sample of middle-aged and older men (n = 3369; mean age 60 +/- 11) participating in the European Male Ageing Study, and whether any associations were explained by lifestyle and health factors. The Beck Depression Inventory-II (BDI-II) was used to screen for depression, and serum 25(OH)D and PTH levels measured by radioimmunoassay. Univariate analysis revealed that 25(OH)D levels were lower (p &lt; 0.001) and PTH higher (p = 0.004) in people with depression. In age- and centre-adjusted linear regressions a higher BDI-II score was significantly associated with tower levels of 25(OH)D (p = 0.004). After adjustment for lifestyle and health factors this relationship was attenuated but remained significant (p = 0.01). Using multivariable logistic regression the odds for depression increased approximately 70% across decreasing 25(OH)D quartiles (p(trend) = 0.04). There was no independent association between PIN and depression in any of the muttivariable regressions. Our results reveal an inverse association between 25(OH)D levels and depression, largely independent of several lifestyle and health factors. Further studies are required to determine whether higher levels of vitamin D have an antidepressant effect in older adults.},
  author       = {Lee, David M. and Tajar, Abdelouahid and O'Neill, Terence W. and O'Connor, Daryl B. and Bartfai, Gyorgy and Boonen, Steven and Bouillon, Roger and Casanueva, Felipe F. and Finn, Joseph D. and Forte, Gianni and Giwercman, Aleksander and Han, Thang S. and Huhtaniemi, Ilpo T. and Kula, Krzysztof and Lean, Michael E. J. and Punab, Margus and Silman, Alan J. and Vanderschueren, Dirk and Wu, Frederick C. W. and Pendleton, Neil},
  issn         = {1461-7285},
  keyword      = {Ageing,depression,male health,parathyroid hormone,population,survey,vitamin D},
  language     = {eng},
  number       = {10},
  pages        = {1320--1328},
  publisher    = {SAGE Publications Inc.},
  series       = {Journal of Psychopharmacology},
  title        = {Lower vitamin D levels are associated with depression among community-dwelling European men},
  url          = {http://dx.doi.org/10.1177/0269881110379287},
  volume       = {25},
  year         = {2011},
}