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Arterial stiffness and 24 h ambulatory blood pressure monitoring in young healthy volunteers: The early vascular ageing Aristotle University Thessaloniki Study (EVA-ARIS Study)

Kotsis, Vasilios; Stabouli, Stella; Karafillis, Ioannis; Papakatsika, Sofia; Rizos, Zoe; Miyakis, Spiros; Goulopoulou, Sofia; Parati, Gianfranco and Nilsson, Peter LU (2011) In Atherosclerosis 219(1). p.194-199
Abstract
Differences in 24 h blood pressure (BP) monitoring parameters such as average 24 h BP, day to night BP ratio and BP variability could have an impact in arterial stiffness. The study hypothesis was that despite similar average BP values in ambulatory blood pressure monitoring subjects with increased 24 h BP variability may have increased arterial stiffness. The study population consisted of 115 consecutive young healthy volunteers. Carotid-femoral PWV was measured in all subjects. Clinic BP was measured and an appropriate cuff was fitted on the non-dominant arm of each subject for a 24 h ambulatory blood pressure monitoring session. Waist to hip ratio as well as BMI was measured. Family history and smoking habits were recorded. In... (More)
Differences in 24 h blood pressure (BP) monitoring parameters such as average 24 h BP, day to night BP ratio and BP variability could have an impact in arterial stiffness. The study hypothesis was that despite similar average BP values in ambulatory blood pressure monitoring subjects with increased 24 h BP variability may have increased arterial stiffness. The study population consisted of 115 consecutive young healthy volunteers. Carotid-femoral PWV was measured in all subjects. Clinic BP was measured and an appropriate cuff was fitted on the non-dominant arm of each subject for a 24 h ambulatory blood pressure monitoring session. Waist to hip ratio as well as BMI was measured. Family history and smoking habits were recorded. In univariate analysis, estimated carotid-femoral PWV showed a significant correlation with age, weight, waist circumference, height, clinic systolic and diastolic BP, 24-h systolic and diastolic BP, 24-h pulse pressure, 24-h systolic and diastolic BP variability, daytime systolic and diastolic BP, daytime pulse pressure, daytime systolic and diastolic BP variability, nighttime systolic BP, nighttime pulse pressure and nighttime systolic BP variability. In multivariate regression analysis, age (B = 0.95, P < 0.001) and 24 h systolic BP variability (B = 0.28, P < 0.001) were independent determinanats of arterial stiffness. In conclusions, increased 24 h systolic BP variability is associated with arterial stiffness in young healthy volunteers. Pulse wave velocity in a young healthy population is useful to identify determinants of premature arterial stiffness, thus further elucidating the aspects of early vascular ageing. (C) 2011 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
24 h Ambulatory blood pressure, Blood pressure variability, Ageing, Arterial stiffness, Early vascular ageing
in
Atherosclerosis
volume
219
issue
1
pages
194 - 199
publisher
Elsevier
external identifiers
  • wos:000296587200029
  • scopus:80054979843
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2011.07.111
language
English
LU publication?
yes
id
e2408629-f3aa-4dc3-a365-bf794772058d (old id 2253393)
date added to LUP
2012-01-02 08:00:32
date last changed
2017-10-01 03:10:12
@article{e2408629-f3aa-4dc3-a365-bf794772058d,
  abstract     = {Differences in 24 h blood pressure (BP) monitoring parameters such as average 24 h BP, day to night BP ratio and BP variability could have an impact in arterial stiffness. The study hypothesis was that despite similar average BP values in ambulatory blood pressure monitoring subjects with increased 24 h BP variability may have increased arterial stiffness. The study population consisted of 115 consecutive young healthy volunteers. Carotid-femoral PWV was measured in all subjects. Clinic BP was measured and an appropriate cuff was fitted on the non-dominant arm of each subject for a 24 h ambulatory blood pressure monitoring session. Waist to hip ratio as well as BMI was measured. Family history and smoking habits were recorded. In univariate analysis, estimated carotid-femoral PWV showed a significant correlation with age, weight, waist circumference, height, clinic systolic and diastolic BP, 24-h systolic and diastolic BP, 24-h pulse pressure, 24-h systolic and diastolic BP variability, daytime systolic and diastolic BP, daytime pulse pressure, daytime systolic and diastolic BP variability, nighttime systolic BP, nighttime pulse pressure and nighttime systolic BP variability. In multivariate regression analysis, age (B = 0.95, P &lt; 0.001) and 24 h systolic BP variability (B = 0.28, P &lt; 0.001) were independent determinanats of arterial stiffness. In conclusions, increased 24 h systolic BP variability is associated with arterial stiffness in young healthy volunteers. Pulse wave velocity in a young healthy population is useful to identify determinants of premature arterial stiffness, thus further elucidating the aspects of early vascular ageing. (C) 2011 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Kotsis, Vasilios and Stabouli, Stella and Karafillis, Ioannis and Papakatsika, Sofia and Rizos, Zoe and Miyakis, Spiros and Goulopoulou, Sofia and Parati, Gianfranco and Nilsson, Peter},
  issn         = {1879-1484},
  keyword      = {24 h Ambulatory blood pressure,Blood pressure variability,Ageing,Arterial stiffness,Early vascular ageing},
  language     = {eng},
  number       = {1},
  pages        = {194--199},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Arterial stiffness and 24 h ambulatory blood pressure monitoring in young healthy volunteers: The early vascular ageing Aristotle University Thessaloniki Study (EVA-ARIS Study)},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2011.07.111},
  volume       = {219},
  year         = {2011},
}