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Laser-induced Fluorescence In Malignant and Normal Tissue of Rats Injected With Benzoporphyrin Derivative

Andersson-Engels, Stefan LU ; Ankerst, J; Johansson, Jonas LU ; Svanberg, Katarina LU and Svanberg, Sune LU (1993) In Photochemistry and Photobiology 57(6). p.978-983
Abstract
Laser-induced fluorescence was used to characterize the localization of intravenously administered benzoporphyrin derivative-monoacid (BPD-MA) 3 h postinjection in different rat tissue types, including an induced experimental malignant tumor. A comparison of the fluorescence properties and the demarcation potential between the newer sensitizer BPD-MA and four other substances, hematoporphyrin (HP), polyhematoporphyrin ester (PHE), tetrasulfonated phthalocyanine (TSPc) and the commercially available Photofrin earlier investigated, is included. The fluorescence light was induced with a nitrogen laser, emitting at 337 nm. The fluorescence spectrum in the region 380-750 nm was analyzed by a polychromator equipped with a diode array detector.... (More)
Laser-induced fluorescence was used to characterize the localization of intravenously administered benzoporphyrin derivative-monoacid (BPD-MA) 3 h postinjection in different rat tissue types, including an induced experimental malignant tumor. A comparison of the fluorescence properties and the demarcation potential between the newer sensitizer BPD-MA and four other substances, hematoporphyrin (HP), polyhematoporphyrin ester (PHE), tetrasulfonated phthalocyanine (TSPc) and the commercially available Photofrin earlier investigated, is included. The fluorescence light was induced with a nitrogen laser, emitting at 337 nm. The fluorescence spectrum in the region 380-750 nm was analyzed by a polychromator equipped with a diode array detector. The demarcation potential between tumor and surrounding tissue in terms of fluorescence signal for the tumor model used was 2:1 for BPD-MA. In comparison with the other drugs, HP shows about the same demarcation potential, whereas Photofrin and PHE exhibit about 3 times better and TSPc about 1.5 times better demarcation. By also employing the endogenous tissue fluorescence signature the contrast was enhanced by a factor of about 2 for each of the five drugs. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Photochemistry and Photobiology
volume
57
issue
6
pages
978 - 983
publisher
American Society for Photobiology
external identifiers
  • scopus:0027621220
ISSN
0031-8655
DOI
10.1111/j.1751-1097.1993.tb02958.x
language
English
LU publication?
yes
id
7dd16d0a-b1dc-4f63-b659-c9b148385832 (old id 2257242)
date added to LUP
2012-02-23 23:44:46
date last changed
2017-01-01 07:36:00
@article{7dd16d0a-b1dc-4f63-b659-c9b148385832,
  abstract     = {Laser-induced fluorescence was used to characterize the localization of intravenously administered benzoporphyrin derivative-monoacid (BPD-MA) 3 h postinjection in different rat tissue types, including an induced experimental malignant tumor. A comparison of the fluorescence properties and the demarcation potential between the newer sensitizer BPD-MA and four other substances, hematoporphyrin (HP), polyhematoporphyrin ester (PHE), tetrasulfonated phthalocyanine (TSPc) and the commercially available Photofrin earlier investigated, is included. The fluorescence light was induced with a nitrogen laser, emitting at 337 nm. The fluorescence spectrum in the region 380-750 nm was analyzed by a polychromator equipped with a diode array detector. The demarcation potential between tumor and surrounding tissue in terms of fluorescence signal for the tumor model used was 2:1 for BPD-MA. In comparison with the other drugs, HP shows about the same demarcation potential, whereas Photofrin and PHE exhibit about 3 times better and TSPc about 1.5 times better demarcation. By also employing the endogenous tissue fluorescence signature the contrast was enhanced by a factor of about 2 for each of the five drugs.},
  author       = {Andersson-Engels, Stefan and Ankerst, J and Johansson, Jonas and Svanberg, Katarina and Svanberg, Sune},
  issn         = {0031-8655},
  language     = {eng},
  number       = {6},
  pages        = {978--983},
  publisher    = {American Society for Photobiology},
  series       = {Photochemistry and Photobiology},
  title        = {Laser-induced Fluorescence In Malignant and Normal Tissue of Rats Injected With Benzoporphyrin Derivative},
  url          = {http://dx.doi.org/10.1111/j.1751-1097.1993.tb02958.x},
  volume       = {57},
  year         = {1993},
}