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Clinical Fluorescence Diagnosis of Human Bladder-carcinoma Following Low-dose Photofrin Injection

Baert, L; Berg, R; Van Damme, B; D'Hallewin, M. A; Johansson, Jonas LU ; Svanberg, Katarina LU and Svanberg, Sune LU (1993) In Urology 41(4). p.322-330
Abstract
A point-monitoring fluorescence diagnostic system based on a low-energy pulsed laser, fiber transmission optics, and an optical multichannel analyzer was used for diagnosis of patients with bladder malignancies. Twenty-four patients with bladder carcinoma, carcinoma in situ, and/or dysplasia were injected with hematoporphyrin derivative, Photofrin, 0.35 or 0.5 mg/kg body weight, forty-eight hours prior to the investigation. The ratio between the red sensitizer emission and the bluish tissue autofluorescence provided excellent demarcation between papillary tumors and normal bladder wall. Certain cases of dysplasia also could be differentiated from normal mucosa. Benign exophytic lesions such as malakoplakia appeared different from malignant... (More)
A point-monitoring fluorescence diagnostic system based on a low-energy pulsed laser, fiber transmission optics, and an optical multichannel analyzer was used for diagnosis of patients with bladder malignancies. Twenty-four patients with bladder carcinoma, carcinoma in situ, and/or dysplasia were injected with hematoporphyrin derivative, Photofrin, 0.35 or 0.5 mg/kg body weight, forty-eight hours prior to the investigation. The ratio between the red sensitizer emission and the bluish tissue autofluorescence provided excellent demarcation between papillary tumors and normal bladder wall. Certain cases of dysplasia also could be differentiated from normal mucosa. Benign exophytic lesions such as malakoplakia appeared different from malignant tumors in fluorescence. Flat suspicious bladder mucosa such as seen in infectious diseases or after radiation therapy appeared normal on fluorescence. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Urology
volume
41
issue
4
pages
322 - 330
publisher
Elsevier
external identifiers
  • scopus:0027520926
ISSN
1527-9995
DOI
10.1016/0090-4295(93)90588-2
language
English
LU publication?
yes
id
1f882579-76d0-4421-bcf6-40c9824f9ba8 (old id 2257394)
date added to LUP
2012-02-23 23:21:08
date last changed
2017-08-27 05:46:19
@article{1f882579-76d0-4421-bcf6-40c9824f9ba8,
  abstract     = {A point-monitoring fluorescence diagnostic system based on a low-energy pulsed laser, fiber transmission optics, and an optical multichannel analyzer was used for diagnosis of patients with bladder malignancies. Twenty-four patients with bladder carcinoma, carcinoma in situ, and/or dysplasia were injected with hematoporphyrin derivative, Photofrin, 0.35 or 0.5 mg/kg body weight, forty-eight hours prior to the investigation. The ratio between the red sensitizer emission and the bluish tissue autofluorescence provided excellent demarcation between papillary tumors and normal bladder wall. Certain cases of dysplasia also could be differentiated from normal mucosa. Benign exophytic lesions such as malakoplakia appeared different from malignant tumors in fluorescence. Flat suspicious bladder mucosa such as seen in infectious diseases or after radiation therapy appeared normal on fluorescence.},
  author       = {Baert, L and Berg, R and Van Damme, B and D'Hallewin, M. A and Johansson, Jonas and Svanberg, Katarina and Svanberg, Sune},
  issn         = {1527-9995},
  language     = {eng},
  number       = {4},
  pages        = {322--330},
  publisher    = {Elsevier},
  series       = {Urology},
  title        = {Clinical Fluorescence Diagnosis of Human Bladder-carcinoma Following Low-dose Photofrin Injection},
  url          = {http://dx.doi.org/10.1016/0090-4295(93)90588-2},
  volume       = {41},
  year         = {1993},
}