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3-Hydroxy fatty acids in saliva as diagnostic markers in chronic periodontitis

Ferrando, R; Szponar, Bogumila LU ; Sanchez, A; Larsson, Lennart LU and Valero-Guillen, P L (2005) In Journal of Microbiological Methods 62(3). p.285-291
Abstract
Saturated straight- and branched-chain 3-hydroxy fatty acids (3-OH FAs) of 10-18 carbon chain lengths were determined in saliva from 27 individuals with chronic periodontitis and 18 healthy individuals by using gas chromatography-tandem mass spectrometry. Of the 14 different 3-OH FAs detected, 3-OH-C-i17:0 was the most abundant in the periodontitis samples while 3-OH-C-14:0 was the most abundant in the healthy individuals. Considering the relative percentages of 3-OH-C-12:0, 3-OH-C-14:0, 3OH-C-i17:0, and 3-OH-C-17:0, 95.6% of all cases were correctly classified as healthy individuals or periodontitis patients by means of discriminant analysis. The sensitivity, specificity, positive predictive value and negative predictive value of 3-OH FA... (More)
Saturated straight- and branched-chain 3-hydroxy fatty acids (3-OH FAs) of 10-18 carbon chain lengths were determined in saliva from 27 individuals with chronic periodontitis and 18 healthy individuals by using gas chromatography-tandem mass spectrometry. Of the 14 different 3-OH FAs detected, 3-OH-C-i17:0 was the most abundant in the periodontitis samples while 3-OH-C-14:0 was the most abundant in the healthy individuals. Considering the relative percentages of 3-OH-C-12:0, 3-OH-C-14:0, 3OH-C-i17:0, and 3-OH-C-17:0, 95.6% of all cases were correctly classified as healthy individuals or periodontitis patients by means of discriminant analysis. The sensitivity, specificity, positive predictive value and negative predictive value of 3-OH FA analysis in diagnosing peridontitis were, respectively, 0.92, 1.00, 1.00, and 0.90. The results indicate that 3-OH FA analysis of saliva samples is a useful diagnostic method in chronic periodontitis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gas chronnatography-mass spectrometry, acids, anaerobic gram-negative bacteria/periodontal pathogens, 3-hydroxy fatty, periodontitis/etiology, microbial chemical, inarkers
in
Journal of Microbiological Methods
volume
62
issue
3
pages
285 - 291
publisher
Elsevier
external identifiers
  • pmid:15941605
  • wos:000231638500004
  • scopus:23744441678
ISSN
1872-8359
DOI
10.1016/j.mimet.2005.04.014
language
English
LU publication?
yes
id
cac91171-dd8c-491b-bbd7-33e906b7d472 (old id 226271)
date added to LUP
2007-09-21 14:39:41
date last changed
2017-01-01 05:00:52
@article{cac91171-dd8c-491b-bbd7-33e906b7d472,
  abstract     = {Saturated straight- and branched-chain 3-hydroxy fatty acids (3-OH FAs) of 10-18 carbon chain lengths were determined in saliva from 27 individuals with chronic periodontitis and 18 healthy individuals by using gas chromatography-tandem mass spectrometry. Of the 14 different 3-OH FAs detected, 3-OH-C-i17:0 was the most abundant in the periodontitis samples while 3-OH-C-14:0 was the most abundant in the healthy individuals. Considering the relative percentages of 3-OH-C-12:0, 3-OH-C-14:0, 3OH-C-i17:0, and 3-OH-C-17:0, 95.6% of all cases were correctly classified as healthy individuals or periodontitis patients by means of discriminant analysis. The sensitivity, specificity, positive predictive value and negative predictive value of 3-OH FA analysis in diagnosing peridontitis were, respectively, 0.92, 1.00, 1.00, and 0.90. The results indicate that 3-OH FA analysis of saliva samples is a useful diagnostic method in chronic periodontitis.},
  author       = {Ferrando, R and Szponar, Bogumila and Sanchez, A and Larsson, Lennart and Valero-Guillen, P L},
  issn         = {1872-8359},
  keyword      = {gas chronnatography-mass spectrometry,acids,anaerobic gram-negative bacteria/periodontal pathogens,3-hydroxy fatty,periodontitis/etiology,microbial chemical,inarkers},
  language     = {eng},
  number       = {3},
  pages        = {285--291},
  publisher    = {Elsevier},
  series       = {Journal of Microbiological Methods},
  title        = {3-Hydroxy fatty acids in saliva as diagnostic markers in chronic periodontitis},
  url          = {http://dx.doi.org/10.1016/j.mimet.2005.04.014},
  volume       = {62},
  year         = {2005},
}