Advanced

Dopamine responsiveness is regulated by targeted sorting of D2 receptors

Bartlett, S E; Enquist, Johan LU ; Hopf, F W; Lee, J H; Gladher, F; Kharazia, V; Waldhoer, M; Mailliard, W S; Armstrong, R and Bonci, A, et al. (2005) In Proceedings of the National Academy of Sciences 102(32). p.11521-11526
Abstract
Aberrant dopaminergic signaling is a critical determinant in multiple psychiatric disorders, and in many disease states, dopamine receptor number is altered. Here we identify a molecular mechanism that selectively targets D2 receptors for degradation after their activation by dopamine. The degradative fate of D2 receptors is determined by an interaction with G protein coupled receptor-associated sorting protein (GASP). As a consequence of this GASP interaction, D2 responses in rat brain fail to resensitize after agonist treatment. Disruption of the D2-GASP interaction facilitates recovery of D2 responses, suggesting that modulation of the D2-GASP interaction is important for the functional down-regulation of D2 receptors.
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
down-regulation, G protein-coupled receptor, trafficking, resensitization, degradation
in
Proceedings of the National Academy of Sciences
volume
102
issue
32
pages
11521 - 11526
publisher
National Acad Sciences
external identifiers
  • wos:000231253400070
  • scopus:23844437253
ISSN
1091-6490
DOI
10.1073/pnas.0502418102
language
English
LU publication?
yes
id
d3d239fa-8527-4ae4-a8a1-6c5fd2189b06 (old id 227121)
date added to LUP
2007-08-08 13:36:43
date last changed
2017-10-22 03:32:45
@article{d3d239fa-8527-4ae4-a8a1-6c5fd2189b06,
  abstract     = {Aberrant dopaminergic signaling is a critical determinant in multiple psychiatric disorders, and in many disease states, dopamine receptor number is altered. Here we identify a molecular mechanism that selectively targets D2 receptors for degradation after their activation by dopamine. The degradative fate of D2 receptors is determined by an interaction with G protein coupled receptor-associated sorting protein (GASP). As a consequence of this GASP interaction, D2 responses in rat brain fail to resensitize after agonist treatment. Disruption of the D2-GASP interaction facilitates recovery of D2 responses, suggesting that modulation of the D2-GASP interaction is important for the functional down-regulation of D2 receptors.},
  author       = {Bartlett, S E and Enquist, Johan and Hopf, F W and Lee, J H and Gladher, F and Kharazia, V and Waldhoer, M and Mailliard, W S and Armstrong, R and Bonci, A and Whistler, J L},
  issn         = {1091-6490},
  keyword      = {down-regulation,G protein-coupled receptor,trafficking,resensitization,degradation},
  language     = {eng},
  number       = {32},
  pages        = {11521--11526},
  publisher    = {National Acad Sciences},
  series       = {Proceedings of the National Academy of Sciences},
  title        = {Dopamine responsiveness is regulated by targeted sorting of D2 receptors},
  url          = {http://dx.doi.org/10.1073/pnas.0502418102},
  volume       = {102},
  year         = {2005},
}