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Polystyrene nanoparticles affecting blood coagulation.

Oslakovic, Cecilia LU ; Cedervall, Tommy LU ; Linse, Sara LU and Dahlbäck, Björn LU (2012) In Nanomedicine: Nanotechnology, Biology and Medicine 8(6). p.981-986
Abstract
Association of nanoparticles with blood coagulation proteins may influence the natural balance between pro-and anticoagulant pathways. We investigated whether polystyrene nanoparticles, when added to human plasma, affected the generation of thrombin in plasma. Amine-modified nanoparticles were found to decrease the thrombin formation due to binding of factor VII and IX to the nanoparticles, which resulted in depletion of the respective protein in solution. In contrast, carboxyl-modified nanoparticles were able to act as a surface for activation of the intrinsic pathway of blood coagulation in plasma. These results highlight the influence of nanoparticles on a biologically important pathway.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nanomedicine: Nanotechnology, Biology and Medicine
volume
8
issue
6
pages
981 - 986
publisher
Elsevier
external identifiers
  • wos:000306662100022
  • pmid:22197724
  • scopus:84864083902
ISSN
1549-9642
DOI
10.1016/j.nano.2011.12.001
language
English
LU publication?
yes
id
1be2138a-d4fe-4b00-85d0-0da63c601b4d (old id 2273551)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22197724?dopt=Abstract
date added to LUP
2012-01-03 22:42:30
date last changed
2017-11-19 04:18:50
@article{1be2138a-d4fe-4b00-85d0-0da63c601b4d,
  abstract     = {Association of nanoparticles with blood coagulation proteins may influence the natural balance between pro-and anticoagulant pathways. We investigated whether polystyrene nanoparticles, when added to human plasma, affected the generation of thrombin in plasma. Amine-modified nanoparticles were found to decrease the thrombin formation due to binding of factor VII and IX to the nanoparticles, which resulted in depletion of the respective protein in solution. In contrast, carboxyl-modified nanoparticles were able to act as a surface for activation of the intrinsic pathway of blood coagulation in plasma. These results highlight the influence of nanoparticles on a biologically important pathway.},
  author       = {Oslakovic, Cecilia and Cedervall, Tommy and Linse, Sara and Dahlbäck, Björn},
  issn         = {1549-9642},
  language     = {eng},
  number       = {6},
  pages        = {981--986},
  publisher    = {Elsevier},
  series       = {Nanomedicine: Nanotechnology, Biology and Medicine},
  title        = {Polystyrene nanoparticles affecting blood coagulation.},
  url          = {http://dx.doi.org/10.1016/j.nano.2011.12.001},
  volume       = {8},
  year         = {2012},
}