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Modelling and optimisation of preparative chromatographic purification of europium.

Ojala, Frida LU ; Max-Hansen, Mark LU ; Kifle, Dejene; Borg, Niklas LU and Nilsson, Bernt LU (2012) In Journal of chromatography. A 1220. p.21-25
Abstract
A model commonly used to describe the separation of biomolecules was used to simulate the harsh environment when eluting neodymium, samarium, europium and gadolinium with a hot acid. After calibration, the model was used to optimise the preparative separation of europium, as this is the most valuable of the four elements. A kinetic dispersive model with a Langmuir mobile phase modulator isotherm was used to describe the process. The equilibration constant, the stoichiometric coefficient and the column capacity for the components were calibrated. The model fitted the experimental observations well. Optimisation was achieved using a differential evolution method. As the two objective functions used in optimising the process, productivity and... (More)
A model commonly used to describe the separation of biomolecules was used to simulate the harsh environment when eluting neodymium, samarium, europium and gadolinium with a hot acid. After calibration, the model was used to optimise the preparative separation of europium, as this is the most valuable of the four elements. A kinetic dispersive model with a Langmuir mobile phase modulator isotherm was used to describe the process. The equilibration constant, the stoichiometric coefficient and the column capacity for the components were calibrated. The model fitted the experimental observations well. Optimisation was achieved using a differential evolution method. As the two objective functions used in optimising the process, productivity and yield, are competing objectives, the result was not a single set point but a Pareto front. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of chromatography. A
volume
1220
pages
21 - 25
publisher
Elsevier
external identifiers
  • wos:000299586000004
  • pmid:22189296
  • scopus:84855346585
ISSN
1873-3778
DOI
10.1016/j.chroma.2011.11.028
language
English
LU publication?
yes
id
d68a7a61-ba2d-4738-9fe4-50f3eab0d7ec (old id 2273724)
date added to LUP
2012-01-12 17:12:12
date last changed
2017-09-03 04:11:40
@article{d68a7a61-ba2d-4738-9fe4-50f3eab0d7ec,
  abstract     = {A model commonly used to describe the separation of biomolecules was used to simulate the harsh environment when eluting neodymium, samarium, europium and gadolinium with a hot acid. After calibration, the model was used to optimise the preparative separation of europium, as this is the most valuable of the four elements. A kinetic dispersive model with a Langmuir mobile phase modulator isotherm was used to describe the process. The equilibration constant, the stoichiometric coefficient and the column capacity for the components were calibrated. The model fitted the experimental observations well. Optimisation was achieved using a differential evolution method. As the two objective functions used in optimising the process, productivity and yield, are competing objectives, the result was not a single set point but a Pareto front.},
  author       = {Ojala, Frida and Max-Hansen, Mark and Kifle, Dejene and Borg, Niklas and Nilsson, Bernt},
  issn         = {1873-3778},
  language     = {eng},
  pages        = {21--25},
  publisher    = {Elsevier},
  series       = {Journal of chromatography. A},
  title        = {Modelling and optimisation of preparative chromatographic purification of europium.},
  url          = {http://dx.doi.org/10.1016/j.chroma.2011.11.028},
  volume       = {1220},
  year         = {2012},
}